TissGeneSummary for SLC6A18 |
Gene summary |
Basic gene information | Gene symbol | SLC6A18 |
Gene name | solute carrier family 6 (neutral amino acid transporter), member 18 | |
Synonyms | Xtrp2 | |
Cytomap | UCSC genome browser: 5p15.33 | |
Type of gene | protein-coding | |
RefGenes | NM_182632.2, | |
Description | sodium channel-like proteinsodium- and chloride-dependent transporter XTRP2sodium-dependent neutral amino acid transporter B(0)AT3solute carrier family 6 (neurotransmitter transporter), member 18solute carrier family 6, member 18system B(0) neutral a | |
Modification date | 20141207 | |
dbXrefs | MIM : 610300 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164363 | ||
HPRD : 15396 | ||
Vega : OTTHUMG00000090356 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC6A18 | |
BioGPS: 348932 | ||
Pathway | NCI Pathway Interaction Database: SLC6A18 | |
KEGG: SLC6A18 | ||
REACTOME: SLC6A18 | ||
Pathway Commons: SLC6A18 | ||
Context | iHOP: SLC6A18 | |
ligand binding site mutation search in PubMed: SLC6A18 | ||
UCL Cancer Institute: SLC6A18 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLC6A18 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC6A18 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.178529321 | 4.181091821 | -4.0025625 | 1.74E-06 | 8.39E-06 |
KICH | -2.235652679 | 3.272127321 | -5.50778 | 1.70E-10 | 1.24E-09 |
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TissGene-miRNA for SLC6A18 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC6A18 |
TissGeneSNV for SLC6A18 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T212P | LUAD | 7 |
p.V100A | HNSC | 1 |
p.R596Q | PAAD | 1 |
p.I169V | LUAD | 1 |
p.Y346H | LUSC | 1 |
p.G39R | KIRP | 1 |
p.D256N | BLCA | 1 |
p.K359T | STAD | 1 |
p.L562R | KIRP | 1 |
p.M497I | SKCM | 1 |
p.A475V | PAAD | 1 |
p.R558S | LUAD | 1 |
p.V61I | CHOL | 1 |
p.T607M | UCS | 1 |
p.P382L | LGG | 1 |
p.V492I | LUAD | 1 |
p.V349I | COAD | 1 |
p.L415I | LUAD | 1 |
p.V349I | HNSC | 1 |
p.Q80K | LUAD | 1 |
p.L537F | SKCM | 1 |
p.P611L | SKCM | 1 |
p.F275S | SKCM | 1 |
p.V89L | KIRC | 1 |
p.A456G | LUSC | 1 |
p.A257T | BRCA | 1 |
p.V349I | STAD | 1 |
p.S94F | SKCM | 1 |
p.G433R | SKCM | 1 |
p.D175N | LUAD | 1 |
p.A476T | HNSC | 1 |
p.P525S | SKCM | 1 |
p.S190F | SKCM | 1 |
p.M404I | LUAD | 1 |
p.R397Q | SKCM | 1 |
p.A274S | SARC | 1 |
p.G408W | LUAD | 1 |
p.R499Q | SKCM | 1 |
p.R252L | THYM | 1 |
p.C449R | HNSC | 1 |
p.D502N | CESC | 1 |
p.A233S | THYM | 1 |
p.A120V | PAAD | 1 |
p.G206W | LGG | 1 |
p.V349F | ESCA | 1 |
p.R83W | UCEC | 1 |
p.C139Y | UCEC | 1 |
p.S477Y | BLCA | 1 |
p.P400S | SKCM | 1 |
p.G270R | UCEC | 1 |
p.S329I | PAAD | 1 |
p.G383S | SKCM | 1 |
p.W21R | BLCA | 1 |
p.A157T | STAD | 1 |
p.W124C | LUAD | 1 |
p.G206R | SKCM | 1 |
p.G565C | LUAD | 1 |
p.G232R | ESCA | 1 |
p.F262S | PRAD | 1 |
p.S342P | LUAD | 1 |
p.F374V | ESCA | 1 |
p.P478L | COAD | 1 |
p.A443V | COAD | 1 |
p.D16Y | LUAD | 1 |
p.G398W | LUAD | 1 |
p.E338X | ESCA | 1 |
p.G39E | UCEC | 1 |
p.A63T | OV | 1 |
p.T91M | COAD | 1 |
p.L224F | SKCM | 1 |
p.R593Q | STAD | 1 |
p.M482T | COAD | 1 |
p.L384V | STAD | 1 |
p.Q589* | SKCM | 1 |
p.N549D | LIHC | 1 |
p.G464E | SKCM | 1 |
p.Y115H | LUAD | 1 |
p.R81L | LUSC | 1 |
p.P514L | SKCM | 1 |
p.G206E | SKCM | 1 |
p.F485L | COAD | 1 |
p.I247F | SKCM | 1 |
p.T316A | SKCM | 1 |
p.A475V | KIRP | 1 |
p.S309F | SKCM | 1 |
p.P514H | HNSC | 1 |
p.G68R | THCA | 1 |
p.R145K | SKCM | 1 |
p.D608H | LUAD | 1 |
p.E560Q | BLCA | 1 |
p.G15R | GBM | 1 |
p.V61I | UCEC | 1 |
p.D472H | CESC | 1 |
p.I470M | READ | 1 |
p.R325K | HNSC | 1 |
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TissGeneCNV for SLC6A18 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC6A18 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC6A18 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC6A18 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC6A18 |
TissGeneDrug for SLC6A18 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC6A18 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 2 | BeFree,CTD_human,GAD |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0268654 | Iminoglycinuria | 1 | BeFree,ORPHANET |
umls:C0543541 | HYPERGLYCINURIA (disorder) | 1 | BeFree |