TissGeneSummary for SLCO4C1 |
Gene summary |
Basic gene information | Gene symbol | SLCO4C1 |
Gene name | solute carrier organic anion transporter family, member 4C1 | |
Synonyms | OATP-H|OATP-M1|OATP4C1|OATPX|PRO2176|SLC21A20 | |
Cytomap | UCSC genome browser: 5q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_180991.4, | |
Description | organic anion transporter M1solute carrier family 21 member 20solute carrier organic anion transporter family member 4C1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609013 | |
HGNC : HGNC | ||
Ensembl : ENSG00000173930 | ||
HPRD : 12354 | ||
Vega : OTTHUMG00000162757 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLCO4C1 | |
BioGPS: 353189 | ||
Pathway | NCI Pathway Interaction Database: SLCO4C1 | |
KEGG: SLCO4C1 | ||
REACTOME: SLCO4C1 | ||
Pathway Commons: SLCO4C1 | ||
Context | iHOP: SLCO4C1 | |
ligand binding site mutation search in PubMed: SLCO4C1 | ||
UCL Cancer Institute: SLCO4C1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of SLCO4C1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLCO4C1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | 2.326204997 | 0.25754059 | 2.068664407 | 1.83E-08 | 8.83E-08 |
COAD | -1.53529761 | 1.882390851 | -3.417688462 | 2.64E-12 | 6.03E-11 |
LUSC | 2.624092435 | 5.457564984 | -2.833472549 | 1.01E-14 | 6.02E-14 |
LIHC | 0.228382082 | 4.195298082 | -3.966916 | 3.29E-12 | 5.85E-11 |
KICH | 2.059218082 | 6.484210082 | -4.424992 | 8.81E-09 | 4.75E-08 |
LUAD | 3.545968703 | 5.842427323 | -2.296458621 | 1.77E-14 | 1.73E-13 |
PRAD | -2.377274533 | -0.25467838 | -2.122596154 | 1.80E-06 | 1.22E-05 |
HNSC | -1.086155034 | 0.34094264 | -1.427097674 | 0.00573 | 0.015167647 |
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TissGene-miRNA for SLCO4C1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLCO4C1 |
TissGeneSNV for SLCO4C1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P430S | SKCM | 3 |
p.G414R | SKCM | 2 |
p.S444X | KIRC | 1 |
p.S695P | ESCA | 1 |
p.G86A | LUAD | 1 |
p.G519E | SKCM | 1 |
p.G270C | KIRP | 1 |
p.G286R | BLCA | 1 |
p.E54* | UCEC | 1 |
p.D646N | SKCM | 1 |
p.R509X | COAD | 1 |
p.I409T | LUSC | 1 |
p.W90X | THYM | 1 |
p.S351F | SKCM | 1 |
p.L80V | LIHC | 1 |
p.H666Y | SKCM | 1 |
p.H608Y | SKCM | 1 |
p.L276F | READ | 1 |
p.T697K | LUSC | 1 |
p.V463A | SKCM | 1 |
p.G724R | SKCM | 1 |
p.Q346E | BLCA | 1 |
p.E549K | PAAD | 1 |
p.S327Y | UCEC | 1 |
p.W322C | LUSC | 1 |
p.L328S | KIRC | 1 |
p.P245S | SKCM | 1 |
p.P525S | BLCA | 1 |
p.Q96* | KIRC | 1 |
p.P14S | SKCM | 1 |
p.E84Q | BLCA | 1 |
p.G242V | LUAD | 1 |
p.G616R | COAD | 1 |
p.L465R | STAD | 1 |
p.C582X | ESCA | 1 |
p.M385I | UCS | 1 |
p.L276S | LUSC | 1 |
p.N43K | COAD | 1 |
p.E479K | SKCM | 1 |
p.E723Q | LUSC | 1 |
p.L378F | BLCA | 1 |
p.Y88* | STAD | 1 |
p.S640I | UCEC | 1 |
p.E84K | BLCA | 1 |
p.H110Y | BRCA | 1 |
p.G595A | LUSC | 1 |
p.R21H | PAAD | 1 |
p.G568E | SKCM | 1 |
p.C156R | BLCA | 1 |
p.F685L | HNSC | 1 |
p.R136H | UCEC | 1 |
p.A432V | ESCA | 1 |
p.R309* | SKCM | 1 |
p.A11T | READ | 1 |
p.R611W | ACC | 1 |
p.Q193* | STAD | 1 |
p.R309X | SKCM | 1 |
p.A252S | UCEC | 1 |
p.G414E | SKCM | 1 |
p.T709N | THYM | 1 |
p.W90X | STAD | 1 |
p.Q50* | ACC | 1 |
p.L23F | LGG | 1 |
p.Q96X | KIRC | 1 |
p.R136H | BLCA | 1 |
p.E72K | SKCM | 1 |
p.I437M | UCEC | 1 |
p.K455E | STAD | 1 |
p.L375V | LUAD | 1 |
p.Y488S | LUAD | 1 |
p.A252V | STAD | 1 |
p.G286R | SKCM | 1 |
p.W657* | SKCM | 1 |
p.R623* | PAAD | 1 |
p.V711A | BRCA | 1 |
p.A457T | DLBC | 1 |
p.D207N | HNSC | 1 |
p.G312E | SKCM | 1 |
p.G414R | STAD | 1 |
p.C582* | ESCA | 1 |
p.E549K | SKCM | 1 |
p.A655V | COAD | 1 |
p.P308S | SKCM | 1 |
p.V388F | PRAD | 1 |
p.G365E | SKCM | 1 |
p.S640N | UCEC | 1 |
p.E198X | LIHC | 1 |
p.A665V | COAD | 1 |
p.E723* | UCEC | 1 |
p.K380N | UCEC | 1 |
p.L75F | STAD | 1 |
p.H354Y | SKCM | 1 |
p.Q99* | SKCM | 1 |
p.M139I | SKCM | 1 |
p.L10F | SARC | 1 |
p.V362M | LGG | 1 |
p.G684R | SKCM | 1 |
p.E198* | UCEC | 1 |
p.R611W | PRAD | 1 |
p.R623* | SKCM | 1 |
p.V388F | LGG | 1 |
p.W90* | STAD | 1 |
p.T466M | LGG | 1 |
p.L320P | KIRC | 1 |
p.S224L | SKCM | 1 |
p.E477K | SKCM | 1 |
p.S333Y | HNSC | 1 |
p.G684X | READ | 1 |
p.E559* | LUSC | 1 |
p.Q436* | ACC | 1 |
p.Y88X | STAD | 1 |
p.V427A | COAD | 1 |
p.S79L | STAD | 1 |
p.P514S | SKCM | 1 |
p.G651E | SKCM | 1 |
p.A499V | GBM | 1 |
p.K171T | UCEC | 1 |
p.T557I | HNSC | 1 |
p.R309Q | COAD | 1 |
p.R611W | PAAD | 1 |
p.S393L | SKCM | 1 |
p.K663N | SKCM | 1 |
p.A420V | STAD | 1 |
p.P278A | THCA | 1 |
p.R611Q | SKCM | 1 |
p.I437M | READ | 1 |
p.I628V | KIRC | 1 |
p.G277D | UCEC | 1 |
p.V116I | LGG | 1 |
p.R623X | READ | 1 |
p.I602V | BRCA | 1 |
p.I275T | HNSC | 1 |
p.F682V | STAD | 1 |
p.F619C | UCS | 1 |
p.W322* | SKCM | 1 |
p.F682V | ESCA | 1 |
p.G89S | UCEC | 1 |
p.Q96E | BLCA | 1 |
p.L405V | STAD | 1 |
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TissGeneCNV for SLCO4C1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLCO4C1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLCO4C1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLCO4C1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLCO4C1 |
TissGeneDrug for SLCO4C1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLCO4C1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 2 | BeFree,GAD |
umls:C1561643 | Chronic Kidney Diseases | 2 | BeFree |