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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AQP5
check button Gene summary
Basic gene informationGene symbolAQP5
Gene nameaquaporin 5
SynonymsAQP-5|PPKB
CytomapUCSC genome browser: 12q13
Type of geneprotein-coding
RefGenesNM_001651.3,
Descriptionaquaporin-5
Modification date20141207
dbXrefs MIM : 600442
HGNC : HGNC
HPRD : 02706
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AQP5
BioGPS: 362
PathwayNCI Pathway Interaction Database: AQP5
KEGG: AQP5
REACTOME: AQP5
Pathway Commons: AQP5
ContextiHOP: AQP5
ligand binding site mutation search in PubMed: AQP5
UCL Cancer Institute: AQP5
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)StomachTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STADTGCT
Reference showing the relevant tissue of AQP5
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0015670carbon dioxide transport19273840
GO:0015670carbon dioxide transport19273840


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TissGeneExp for AQP5

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC-1.797452072.870820023-4.6682720939.01E-088.93E-07
KICH-3.3739146750.109369325-3.4832848.77E-116.81E-10
BRCA-1.1966119031.468247746-2.6648596491.57E-106.08E-10
KIRP-3.5962113-0.59565505-3.000556255.60E-105.48E-09
PRAD-2.186393752-0.058499521-2.1278942314.76E-121.75E-10
LUSC-0.9265393022.473045011-3.3995843144.18E-111.63E-10
KIRC-4.363190119-0.920441508-3.4427486113.30E-391.28E-37
COAD-2.20910529-4.1134399061.9043346150.01070.023234589
LUAD1.8025741533.314734497-1.5121603450.002660.005409229
THCA2.3589191561.0493632231.3095559323.63E-050.000107301


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TissGene-miRNA for AQP5

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for AQP5
TissGeneSNV for AQP5

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V14MBLCA1
p.P227LBLCA1
p.S31WBRCA1
p.P210SLIHC1
p.R256WUCEC1
p.Q58*SKCM1
p.G30SSARC1
p.S37LBLCA1
p.L122RSTAD1
p.G30DSARC1
p.L76FCESC1
p.R256QSTAD1
p.G30DLGG1
p.A16TCOAD1
p.R235HUCS1
p.A71TSTAD1
p.A46VSTAD1
p.A71SLUSC1
p.L163PLAML1
p.V195LLIHC1
p.A193VTHCA1
p.V8LLUSC1
p.I177MBLCA1
p.A193VSTAD1


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TissGeneCNV for AQP5

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for AQP5

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0TopHat-FusionLUADTCGA-62-A46S-01ALOC101927318-AQP5Out-of-Framechr12:50356083chr12:50357281
Chimerdb3.0TopHat-FusionOVTCGA-13-1481-01ALOC101927318-AQP5Out-of-Framechr12:50356104chr12:50358966
Chimerdb3.0TopHat-FusionBRCATCGA-A1-A0SO-01ALOC101927318-AQP5Out-of-Framechr12:50356075chr12:50357299
Chimerdb3.0TopHat-FusionBRCATCGA-BH-A1EN-01ALOC101927318-AQP5Out-of-Framechr12:50356090chr12:50357274


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TissGeneNet for AQP5

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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COAD (tumor)COAD (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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HNSC (tumor)HNSC (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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KICH (tumor)KICH (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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KIRC (tumor)KIRC (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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KIRP (tumor)KIRP (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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LIHC (tumor)LIHC (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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LUAD (tumor)LUAD (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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LUSC (tumor)LUSC (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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PRAD (tumor)PRAD (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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STAD (tumor)STAD (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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THCA (tumor)THCA (normal)
AQP5, MDFI, GLRX, WNT2 (tumor)AQP5, MDFI, GLRX, WNT2 (normal)
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TissGeneProg for AQP5

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for AQP5
TissGeneDrug for AQP5

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for AQP5

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027627Neoplasm Metastasis7BeFree
umls:C0596263Carcinogenesis6BeFree
umls:C0686619Secondary malignant neoplasm of lymph node5BeFree
umls:C0024117Chronic Obstructive Airway Disease4BeFree,GAD,LHGDN
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C1559271Non-Malignant Ascites Adverse Event3BeFree
umls:C0007102Malignant tumor of colon2BeFree
umls:C0019284Diaphragmatic Hernia2CTD_human
umls:C0022578Keratoconus2BeFree,LHGDN
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0036690Septicemia2BeFree
umls:C0243026Sepsis2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0521158Recurrent tumor2BeFree
umls:C0677886Epithelial ovarian cancer2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0919267ovarian neoplasm2BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007120Bronchioloalveolar Adenocarcinoma1BeFree
umls:C0007121Bronchogenic Carcinoma1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0007786Brain Ischemia1RGD
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0010606Adenoid Cystic Carcinoma1BeFree
umls:C0011881Diabetic Nephropathy1BeFree
umls:C0023473Myeloid Leukemia, Chronic1LHGDN
umls:C0025286Meningioma1BeFree
umls:C0032617Polyuria1BeFree
umls:C0034063Pulmonary Edema1BeFree
umls:C0043352Xerostomia1BeFree
umls:C0086692Benign Neoplasm1BeFree
umls:C0175754Agenesis of corpus callosum1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0349566Squamous cell carcinoma of tongue1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C1260954Morphologically altered structure1BeFree
umls:C1527311Brain Edema1BeFree
umls:C1719672Severe Sepsis1BeFree
umls:C1762616Meningioma, benign, no ICD-O subtype1BeFree
umls:C1838359Diffuse palmoplantar keratoderma, Bothnian type1CLINVAR,ORPHANET,UNIPROT
umls:C1956346Coronary Artery Disease1BeFree,GAD,LHGDN