TissGeneSummary for INHBC |
Gene summary |
Basic gene information | Gene symbol | INHBC |
Gene name | inhibin, beta C | |
Synonyms | IHBC | |
Cytomap | UCSC genome browser: 12q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_005538.3, | |
Description | activin beta-C chaininhibin beta C chain | |
Modification date | 20141207 | |
dbXrefs | MIM : 601233 | |
HGNC : HGNC | ||
HPRD : 03136 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_INHBC | |
BioGPS: 3626 | ||
Pathway | NCI Pathway Interaction Database: INHBC | |
KEGG: INHBC | ||
REACTOME: INHBC | ||
Pathway Commons: INHBC | ||
Context | iHOP: INHBC | |
ligand binding site mutation search in PubMed: INHBC | ||
UCL Cancer Institute: INHBC | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of INHBC | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for INHBC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.161717169 | 0.461584526 | -1.623301695 | 1.22E-11 | 9.25E-11 |
LIHC | 6.421098526 | 8.428182526 | -2.007084 | 4.34E-07 | 2.56E-06 |
ESCA | -1.077588201 | -2.292651838 | 1.215063636 | 0.00189 | 0.022122947 |
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TissGene-miRNA for INHBC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for INHBC |
TissGeneSNV for INHBC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G85R | SKCM | 1 |
p.V17A | LIHC | 1 |
p.I277L | LUSC | 1 |
p.S209L | SKCM | 1 |
p.A321T | SKCM | 1 |
p.R322Q | COAD | 1 |
p.A272T | COAD | 1 |
p.R245G | THCA | 1 |
p.H78P | HNSC | 1 |
p.T163I | SKCM | 1 |
p.N335K | STAD | 1 |
p.D53N | SKCM | 1 |
p.P14S | SKCM | 1 |
p.R257C | SKCM | 1 |
p.D331N | STAD | 1 |
p.H234N | ESCA | 1 |
p.G278W | STAD | 1 |
p.L328F | PAAD | 1 |
p.W264X | SKCM | 1 |
p.T144S | LUAD | 1 |
p.A272V | STAD | 1 |
p.A216V | HNSC | 1 |
p.R249Q | READ | 1 |
p.E93K | SKCM | 1 |
p.K338N | ESCA | 1 |
p.G203D | SKCM | 1 |
p.Q279X | STAD | 1 |
p.A272T | UCEC | 1 |
p.Q131E | HNSC | 1 |
p.W264* | SKCM | 1 |
p.Q192* | BRCA | 1 |
p.K338N | UCEC | 1 |
p.G156C | LUAD | 1 |
p.T320M | STAD | 1 |
p.A308S | CESC | 1 |
p.P288S | COAD | 1 |
p.T320K | BLCA | 1 |
p.A206T | UCEC | 1 |
p.R113S | LUAD | 1 |
p.D263N | READ | 1 |
p.Q279* | STAD | 1 |
p.D239N | SKCM | 1 |
p.G243E | SKCM | 1 |
p.L169V | LUAD | 1 |
p.M273I | SKCM | 1 |
p.R236* | PRAD | 1 |
p.R245K | SKCM | 1 |
p.G193R | SKCM | 1 |
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TissGeneCNV for INHBC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for INHBC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for INHBC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for INHBC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for INHBC |
TissGeneDrug for INHBC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for INHBC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | GAD |
umls:C0039590 | Testicular Neoplasms | 1 | GAD |
umls:C0220650 | Metastatic malignant neoplasm to brain | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |