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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for ITIH3
check button Gene summary
Basic gene informationGene symbolITIH3
Gene nameinter-alpha-trypsin inhibitor heavy chain 3
SynonymsH3P
CytomapUCSC genome browser: 3p21.1
Type of geneprotein-coding
RefGenesNM_002217.3,
DescriptionITI heavy chain H3ITI-HC3SHAPinter-alpha (globulin) inhibitor H3inter-alpha (globulin) inhibitor, H3 polypeptideinter-alpha-inhibitor heavy chain 3inter-alpha-trypsin inhibitor heavy chain H3pre-alpha (globulin) inhibitor, H3 polypeptideserum-deri
Modification date20141207
dbXrefs MIM : 146650
HGNC : HGNC
Ensembl : ENSG00000162267
HPRD : 00891
Vega : OTTHUMG00000158956
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ITIH3
BioGPS: 3699
PathwayNCI Pathway Interaction Database: ITIH3
KEGG: ITIH3
REACTOME: ITIH3
Pathway Commons: ITIH3
ContextiHOP: ITIH3
ligand binding site mutation search in PubMed: ITIH3
UCL Cancer Institute: ITIH3
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of ITIH3
Description by TissGene annotationsCancer gene
TissgsKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for ITIH3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-0.6253058352.712870635-3.3381764715.28E-206.33E-19
BRCA-0.8838934510.835408303-1.7193017547.50E-205.27E-19
THCA-1.4008469450.159361529-1.5602084753.85E-112.71E-10
LUAD0.3621422712.096483651-1.7343413792.06E-121.56E-11
BLCA-1.4356952060.488683742-1.9243789470.0002880.002614335
KIRP-0.5767090220.842753478-1.41946250.0004960.00145936


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TissGene-miRNA for ITIH3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for ITIH3
TissGeneSNV for ITIH3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E481KSKCM2
p.G691EREAD1
p.R546WBLCA1
p.E168KSKCM1
p.R678CLIHC1
p.G418CUCEC1
p.H60YLUSC1
p.P405HLIHC1
p.P23QTHYM1
p.R678HSTAD1
p.I323TOV1
p.P36RLUSC1
p.S743IACC1
p.R678CPRAD1
p.M539ISKCM1
p.D746HHNSC1
p.R546WUCEC1
p.V869ILUSC1
p.P7LUCEC1
p.G38WHNSC1
p.R448WLIHC1
p.E568KLGG1
p.T806MHNSC1
p.A2SSTAD1
p.P630TSTAD1
p.R678SLUAD1
p.V68IUCEC1
p.L557HPRAD1
p.W558CUCEC1
p.T86MUCEC1
p.S700NUCEC1
p.R234CCOAD1
p.R546QBLCA1
p.Y553HHNSC1
p.V280ASTAD1
p.R57GSKCM1
p.L14FOV1
p.A18TUCEC1
p.P470LSKCM1
p.R28QCOAD1
p.H444RBLCA1
p.Y167CPAAD1
p.D857NSKCM1
p.R678HUCEC1
p.L135WSKCM1
p.S78FKIRP1
p.F272YBRCA1
p.E107KBLCA1
p.G861SLGG1
p.A716TSTAD1
p.R678HLGG1
p.L209MUCEC1
p.Q345KLUSC1
p.P833LLUAD1
p.I289VSTAD1
p.T93IPAAD1
p.G873ESKCM1
p.R546QSKCM1
p.W734*SKCM1
p.G38RPAAD1
p.L30FGBM1
p.A573TSTAD1
p.R736KSKCM1
p.A398VCOAD1
p.A623TSTAD1
p.W5*LIHC1
p.V869IGBM1
p.R234CUCEC1
p.D670NUCEC1
p.R70HREAD1
p.A614VCOAD1
p.T90ACESC1
p.L472MUCEC1
p.L213ILIHC1
p.D313NUCS1
p.F27VSTAD1
p.D457NCESC1
p.V869IKIRC1
p.K357*SKCM1
p.V68ISKCM1


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TissGeneCNV for ITIH3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for ITIH3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAI065091ITIH3-SPTLC1chr3:52839336chr9:94809464


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TissGeneNet for ITIH3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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COAD (tumor)COAD (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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HNSC (tumor)HNSC (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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KICH (tumor)KICH (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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KIRC (tumor)KIRC (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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KIRP (tumor)KIRP (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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LIHC (tumor)LIHC (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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LUAD (tumor)LUAD (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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LUSC (tumor)LUSC (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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PRAD (tumor)PRAD (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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STAD (tumor)STAD (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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THCA (tumor)THCA (normal)
ITIH3, PITX3, EP300, SPINT2 (tumor)ITIH3, PITX3, EP300, SPINT2 (normal)
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TissGeneProg for ITIH3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for ITIH3
TissGeneDrug for ITIH3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for ITIH3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0036341Schizophrenia3BeFree,GWASCAT
umls:C0005586Bipolar Disorder2BeFree,GAD
umls:C0004936Mental disorders1BeFree
umls:C0027051Myocardial Infarction1BeFree,GAD,LHGDN
umls:C0027627Neoplasm Metastasis1LHGDN
umls:C0033975Psychotic Disorders1BeFree
umls:C0042018Urinary Calculi1LHGDN
umls:C0349204Nonorganic psychosis1BeFree
umls:C2239176Liver carcinoma1CTD_human