TissGeneSummary for ITIH3 |
Gene summary |
Basic gene information | Gene symbol | ITIH3 |
Gene name | inter-alpha-trypsin inhibitor heavy chain 3 | |
Synonyms | H3P | |
Cytomap | UCSC genome browser: 3p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002217.3, | |
Description | ITI heavy chain H3ITI-HC3SHAPinter-alpha (globulin) inhibitor H3inter-alpha (globulin) inhibitor, H3 polypeptideinter-alpha-inhibitor heavy chain 3inter-alpha-trypsin inhibitor heavy chain H3pre-alpha (globulin) inhibitor, H3 polypeptideserum-deri | |
Modification date | 20141207 | |
dbXrefs | MIM : 146650 | |
HGNC : HGNC | ||
Ensembl : ENSG00000162267 | ||
HPRD : 00891 | ||
Vega : OTTHUMG00000158956 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITIH3 | |
BioGPS: 3699 | ||
Pathway | NCI Pathway Interaction Database: ITIH3 | |
KEGG: ITIH3 | ||
REACTOME: ITIH3 | ||
Pathway Commons: ITIH3 | ||
Context | iHOP: ITIH3 | |
ligand binding site mutation search in PubMed: ITIH3 | ||
UCL Cancer Institute: ITIH3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ITIH3 | ||
Description by TissGene annotations | Cancer gene TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ITIH3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.625305835 | 2.712870635 | -3.338176471 | 5.28E-20 | 6.33E-19 |
BRCA | -0.883893451 | 0.835408303 | -1.719301754 | 7.50E-20 | 5.27E-19 |
THCA | -1.400846945 | 0.159361529 | -1.560208475 | 3.85E-11 | 2.71E-10 |
LUAD | 0.362142271 | 2.096483651 | -1.734341379 | 2.06E-12 | 1.56E-11 |
BLCA | -1.435695206 | 0.488683742 | -1.924378947 | 0.000288 | 0.002614335 |
KIRP | -0.576709022 | 0.842753478 | -1.4194625 | 0.000496 | 0.00145936 |
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TissGene-miRNA for ITIH3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ITIH3 |
TissGeneSNV for ITIH3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E481K | SKCM | 2 |
p.G691E | READ | 1 |
p.R546W | BLCA | 1 |
p.E168K | SKCM | 1 |
p.R678C | LIHC | 1 |
p.G418C | UCEC | 1 |
p.H60Y | LUSC | 1 |
p.P405H | LIHC | 1 |
p.P23Q | THYM | 1 |
p.R678H | STAD | 1 |
p.I323T | OV | 1 |
p.P36R | LUSC | 1 |
p.S743I | ACC | 1 |
p.R678C | PRAD | 1 |
p.M539I | SKCM | 1 |
p.D746H | HNSC | 1 |
p.R546W | UCEC | 1 |
p.V869I | LUSC | 1 |
p.P7L | UCEC | 1 |
p.G38W | HNSC | 1 |
p.R448W | LIHC | 1 |
p.E568K | LGG | 1 |
p.T806M | HNSC | 1 |
p.A2S | STAD | 1 |
p.P630T | STAD | 1 |
p.R678S | LUAD | 1 |
p.V68I | UCEC | 1 |
p.L557H | PRAD | 1 |
p.W558C | UCEC | 1 |
p.T86M | UCEC | 1 |
p.S700N | UCEC | 1 |
p.R234C | COAD | 1 |
p.R546Q | BLCA | 1 |
p.Y553H | HNSC | 1 |
p.V280A | STAD | 1 |
p.R57G | SKCM | 1 |
p.L14F | OV | 1 |
p.A18T | UCEC | 1 |
p.P470L | SKCM | 1 |
p.R28Q | COAD | 1 |
p.H444R | BLCA | 1 |
p.Y167C | PAAD | 1 |
p.D857N | SKCM | 1 |
p.R678H | UCEC | 1 |
p.L135W | SKCM | 1 |
p.S78F | KIRP | 1 |
p.F272Y | BRCA | 1 |
p.E107K | BLCA | 1 |
p.G861S | LGG | 1 |
p.A716T | STAD | 1 |
p.R678H | LGG | 1 |
p.L209M | UCEC | 1 |
p.Q345K | LUSC | 1 |
p.P833L | LUAD | 1 |
p.I289V | STAD | 1 |
p.T93I | PAAD | 1 |
p.G873E | SKCM | 1 |
p.R546Q | SKCM | 1 |
p.W734* | SKCM | 1 |
p.G38R | PAAD | 1 |
p.L30F | GBM | 1 |
p.A573T | STAD | 1 |
p.R736K | SKCM | 1 |
p.A398V | COAD | 1 |
p.A623T | STAD | 1 |
p.W5* | LIHC | 1 |
p.V869I | GBM | 1 |
p.R234C | UCEC | 1 |
p.D670N | UCEC | 1 |
p.R70H | READ | 1 |
p.A614V | COAD | 1 |
p.T90A | CESC | 1 |
p.L472M | UCEC | 1 |
p.L213I | LIHC | 1 |
p.D313N | UCS | 1 |
p.F27V | STAD | 1 |
p.D457N | CESC | 1 |
p.V869I | KIRC | 1 |
p.K357* | SKCM | 1 |
p.V68I | SKCM | 1 |
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TissGeneCNV for ITIH3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ITIH3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI065091 | ITIH3-SPTLC1 | chr3:52839336 | chr9:94809464 |
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TissGeneNet for ITIH3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ITIH3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ITIH3 |
TissGeneDrug for ITIH3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ITIH3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 3 | BeFree,GWASCAT |
umls:C0005586 | Bipolar Disorder | 2 | BeFree,GAD |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0027051 | Myocardial Infarction | 1 | BeFree,GAD,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 1 | LHGDN |
umls:C0033975 | Psychotic Disorders | 1 | BeFree |
umls:C0042018 | Urinary Calculi | 1 | LHGDN |
umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | CTD_human |