TissGeneSummary for CDRT1 |
Gene summary |
Basic gene information | Gene symbol | CDRT1 |
Gene name | CMT1A duplicated region transcript 1 | |
Synonyms | C170RF1|C17ORF1|C17ORF1A|FBXW10B|FBXW10P1|HREP|SM25H2 | |
Cytomap | UCSC genome browser: 17p12 | |
Type of gene | protein-coding | |
RefGenes | NM_001282540.1, NM_006382.3, | |
Description | CMT1A duplicated region transcript 1 proteinCharcot-Marie-Tooth duplicated region transcript 1F-box and WD repeat domain containing 10 pseudogene 1F-box and WD-40 domain protein 10 pseudogene 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604596 | |
HGNC : HGNC | ||
Ensembl : ENSG00000241322 | ||
HPRD : 16699 | ||
Vega : OTTHUMG00000059074 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CDRT1 | |
BioGPS: 374286 | ||
Pathway | NCI Pathway Interaction Database: CDRT1 | |
KEGG: CDRT1 | ||
REACTOME: CDRT1 | ||
Pathway Commons: CDRT1 | ||
Context | iHOP: CDRT1 | |
ligand binding site mutation search in PubMed: CDRT1 | ||
UCL Cancer Institute: CDRT1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CDRT1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CDRT1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.377800352 | -2.400384967 | 1.022584615 | 0.000943 | 0.002711434 |
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TissGene-miRNA for CDRT1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CDRT1 |
TissGeneSNV for CDRT1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A598V | UCEC | 1 |
p.G471R | UCEC | 1 |
p.T295I | UCEC | 1 |
p.C632Y | LGG | 1 |
p.R450Q | BRCA | 1 |
p.S90F | STAD | 1 |
p.V356A | UCEC | 1 |
p.R607C | COAD | 1 |
p.G359W | LIHC | 1 |
p.A693V | OV | 1 |
p.R232W | SKCM | 1 |
p.H494Q | OV | 1 |
p.S235F | OV | 1 |
p.S335P | COAD | 1 |
p.K188T | DLBC | 1 |
p.S476T | COAD | 1 |
p.S104F | BLCA | 1 |
p.E236K | SKCM | 1 |
p.F643L | COAD | 1 |
p.R489Q | UCEC | 1 |
p.R638Q | UCEC | 1 |
p.P24S | SKCM | 1 |
p.R15C | SKCM | 1 |
p.I651M | HNSC | 1 |
p.T683M | UCEC | 1 |
p.H674Y | SKCM | 1 |
p.D342Y | OV | 1 |
p.E394K | SKCM | 1 |
p.A302T | UCEC | 1 |
p.S361T | BRCA | 1 |
p.E2G | HNSC | 1 |
p.R432Q | UCEC | 1 |
p.K147N | UCEC | 1 |
p.G82R | BRCA | 1 |
p.A11V | STAD | 1 |
p.S472G | UCEC | 1 |
p.T840M | UCEC | 1 |
p.V391F | ESCA | 1 |
p.M362I | KIRC | 1 |
p.Q201E | CESC | 1 |
p.T411M | COAD | 1 |
p.R553* | UCEC | 1 |
p.Q696X | SKCM | 1 |
p.D21N | STAD | 1 |
p.S719L | UCEC | 1 |
p.D620N | UCEC | 1 |
p.R15H | STAD | 1 |
p.Q696* | SKCM | 1 |
p.R353C | KICH | 1 |
p.P739L | SKCM | 1 |
p.S6* | BLCA | 1 |
p.W679* | LUSC | 1 |
p.S308* | OV | 1 |
p.E236K | READ | 1 |
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TissGeneCNV for CDRT1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CDRT1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CDRT1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CDRT1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CDRT1 |
TissGeneDrug for CDRT1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CDRT1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011991 | Diarrhea | 1 | BeFree |
umls:C0242422 | Parkinsonian Disorders | 1 | BeFree |