TissGeneSummary for CCDC178 |
Gene summary |
Basic gene information | Gene symbol | CCDC178 |
Gene name | coiled-coil domain containing 178 | |
Synonyms | C18orf34 | |
Cytomap | UCSC genome browser: 18q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001105528.1, NM_198995.2, | |
Description | coiled-coil domain-containing protein 178 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000166960 | ||
HPRD : 12691 | ||
Vega : OTTHUMG00000132279 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC178 | |
BioGPS: 374864 | ||
Pathway | NCI Pathway Interaction Database: CCDC178 | |
KEGG: CCDC178 | ||
REACTOME: CCDC178 | ||
Pathway Commons: CCDC178 | ||
Context | iHOP: CCDC178 | |
ligand binding site mutation search in PubMed: CCDC178 | ||
UCL Cancer Institute: CCDC178 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC178 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC178 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC178 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC178 |
TissGeneSNV for CCDC178 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M662I | SKCM | 4 |
p.W34* | SKCM | 2 |
p.E107K | SKCM | 2 |
p.M200I | SKCM | 2 |
p.E369K | SKCM | 2 |
p.A216S | LUAD | 1 |
p.D203H | ACC | 1 |
p.R82X | DLBC | 1 |
p.Y79C | STAD | 1 |
p.T141S | LUAD | 1 |
p.E25K | SKCM | 1 |
p.Q104* | SKCM | 1 |
p.S11F | SKCM | 1 |
p.A339D | LUAD | 1 |
p.S85N | SKCM | 1 |
p.N738D | SKCM | 1 |
p.F812Y | LIHC | 1 |
p.D459E | STAD | 1 |
p.E185* | LUAD | 1 |
p.D866N | SKCM | 1 |
p.K740T | SKCM | 1 |
p.H805Q | LUAD | 1 |
p.N776D | SKCM | 1 |
p.I442T | PAAD | 1 |
p.Q282* | SKCM | 1 |
p.Q407H | LIHC | 1 |
p.M163I | SKCM | 1 |
p.P157L | LUAD | 1 |
p.E644Q | LUAD | 1 |
p.F509L | BLCA | 1 |
p.Q801H | BLCA | 1 |
p.Q104X | SKCM | 1 |
p.E31Q | LUAD | 1 |
p.T467N | STAD | 1 |
p.E755K | SKCM | 1 |
p.K155N | STAD | 1 |
p.M43L | BLCA | 1 |
p.N694K | STAD | 1 |
p.Q282X | SKCM | 1 |
p.R566Q | SKCM | 1 |
p.V88A | PRAD | 1 |
p.P142L | SKCM | 1 |
p.S349I | LUAD | 1 |
p.D327N | LUAD | 1 |
p.D296N | BLCA | 1 |
p.R126I | SARC | 1 |
p.R703T | BLCA | 1 |
p.D329Y | LUAD | 1 |
p.K702T | SKCM | 1 |
p.L564P | BLCA | 1 |
p.Q232K | STAD | 1 |
p.E169G | KIRP | 1 |
p.I505F | LUAD | 1 |
p.P92T | LUAD | 1 |
p.Q809* | PRAD | 1 |
p.I558N | BLCA | 1 |
p.A577V | SKCM | 1 |
p.L396F | STAD | 1 |
p.E826K | SKCM | 1 |
p.D105E | CHOL | 1 |
p.F121L | SKCM | 1 |
p.A182E | CESC | 1 |
p.Q809X | PRAD | 1 |
p.A441S | LUAD | 1 |
p.I202N | LUAD | 1 |
p.A824S | HNSC | 1 |
p.G623E | SKCM | 1 |
p.C720F | LUAD | 1 |
p.R528K | SKCM | 1 |
p.K54M | LUAD | 1 |
p.V7F | LUAD | 1 |
p.E478K | SKCM | 1 |
p.L396F | LUAD | 1 |
p.S204F | SKCM | 1 |
p.D686V | BLCA | 1 |
p.R83P | BLCA | 1 |
p.P80S | SKCM | 1 |
p.R630Q | STAD | 1 |
p.E306K | PRAD | 1 |
p.E374K | LUAD | 1 |
p.F77V | STAD | 1 |
p.L800Q | LIHC | 1 |
p.S786* | BLCA | 1 |
p.R398T | BLCA | 1 |
p.S168* | BLCA | 1 |
p.E864K | SKCM | 1 |
p.P214S | LUAD | 1 |
p.W233L | LUAD | 1 |
p.R194K | HNSC | 1 |
p.A639T | LUAD | 1 |
p.R472W | KIRC | 1 |
p.E726Q | HNSC | 1 |
p.M197I | CESC | 1 |
p.H410Y | SKCM | 1 |
p.M549I | LUAD | 1 |
p.D329N | SKCM | 1 |
p.E164K | SKCM | 1 |
p.T450M | BLCA | 1 |
p.P92L | SKCM | 1 |
p.H84Y | SKCM | 1 |
p.C23F | LUAD | 1 |
p.D492N | SKCM | 1 |
p.R566Q | PRAD | 1 |
p.Y345H | LUAD | 1 |
p.T859S | LUAD | 1 |
p.Q45* | BLCA | 1 |
p.M821I | BLCA | 1 |
p.I575T | LUAD | 1 |
p.M200I | HNSC | 1 |
p.V399I | SKCM | 1 |
p.V217M | CHOL | 1 |
p.M197I | SARC | 1 |
p.H510Y | BLCA | 1 |
p.I229L | LIHC | 1 |
p.V399F | KIRC | 1 |
p.K624N | LUAD | 1 |
p.R181Q | STAD | 1 |
p.S275C | BLCA | 1 |
p.V217L | LUAD | 1 |
p.K54N | SKCM | 1 |
p.A257G | TGCT | 1 |
p.E394K | SKCM | 1 |
p.T467N | ESCA | 1 |
p.E716D | LUAD | 1 |
p.D866N | SARC | 1 |
p.R758C | ACC | 1 |
p.Q16K | LUAD | 1 |
p.L771I | LUAD | 1 |
p.P214S | SKCM | 1 |
p.A319V | LUAD | 1 |
p.R720C | ACC | 1 |
p.E681V | ESCA | 1 |
p.K425T | STAD | 1 |
p.I641M | LUAD | 1 |
p.T688I | PRAD | 1 |
p.Q277H | LUAD | 1 |
p.D751H | STAD | 1 |
p.K794M | LIHC | 1 |
p.K740N | HNSC | 1 |
p.H61Y | BLCA | 1 |
p.R647L | LIHC | 1 |
p.L742V | BLCA | 1 |
p.Q552* | LUAD | 1 |
p.T12I | LUAD | 1 |
p.R472W | DLBC | 1 |
p.E385K | SKCM | 1 |
p.Y354H | LUAD | 1 |
p.D860Y | LUAD | 1 |
p.D14N | KIRP | 1 |
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TissGeneCNV for CCDC178 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC178 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CCDC178 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC178 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC178 |
TissGeneDrug for CCDC178 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC178 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033578 | Prostatic Neoplasms | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |