TissGeneSummary for MROH7 |
Gene summary |
Basic gene information | Gene symbol | MROH7 |
Gene name | maestro heat-like repeat family member 7 | |
Synonyms | C1orf175|HEATR8 | |
Cytomap | UCSC genome browser: 1p32.3 | |
Type of gene | protein-coding | |
RefGenes | NM_198547.1, NM_001039464.3,NM_001291332.1,NR_026782.2,NR_111931.1, | |
Description | HEAT repeat-containing protein 8maestro heat-like repeat-containing protein family member 7 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000184313 | ||
HPRD : 10993 | ||
Vega : OTTHUMG00000009890 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MROH7 | |
BioGPS: 374977 | ||
Pathway | NCI Pathway Interaction Database: MROH7 | |
KEGG: MROH7 | ||
REACTOME: MROH7 | ||
Pathway Commons: MROH7 | ||
Context | iHOP: MROH7 | |
ligand binding site mutation search in PubMed: MROH7 | ||
UCL Cancer Institute: MROH7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MROH7 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MROH7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for MROH7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MROH7 |
TissGeneSNV for MROH7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R1237C | SKCM | 3 |
p.E553K | LUAD | 2 |
p.P899S | SKCM | 2 |
p.E1140K | SKCM | 2 |
p.S517F | SKCM | 2 |
p.E274K | SKCM | 2 |
p.G944E | SKCM | 2 |
p.G796R | SKCM | 1 |
p.I616M | SARC | 1 |
p.S853N | SKCM | 1 |
p.R1101C | LUAD | 1 |
p.L990F | SKCM | 1 |
p.L1321F | LUAD | 1 |
p.P1227L | SKCM | 1 |
p.C810S | LUAD | 1 |
p.S562C | PAAD | 1 |
p.E927* | LUAD | 1 |
p.L615F | HNSC | 1 |
p.V770F | LUAD | 1 |
p.G749D | ESCA | 1 |
p.K361X | LIHC | 1 |
p.R120H | ESCA | 1 |
p.L1153M | LGG | 1 |
p.G74D | SKCM | 1 |
p.G1280R | SKCM | 1 |
p.V851G | SARC | 1 |
p.V828I | PAAD | 1 |
p.R499W | STAD | 1 |
p.S346R | DLBC | 1 |
p.P1227S | SKCM | 1 |
p.E993K | SKCM | 1 |
p.D60A | KIRP | 1 |
p.P242S | SKCM | 1 |
p.P123L | SKCM | 1 |
p.A527S | ESCA | 1 |
p.R833Q | SKCM | 1 |
p.L1248F | ESCA | 1 |
p.C810G | SKCM | 1 |
p.P81L | PRAD | 1 |
p.T495I | LUAD | 1 |
p.R479C | PAAD | 1 |
p.P204S | SKCM | 1 |
p.E993* | CESC | 1 |
p.R1116Q | SKCM | 1 |
p.R763H | STAD | 1 |
p.G190C | LUAD | 1 |
p.W932* | SKCM | 1 |
p.R738S | THYM | 1 |
p.A42T | SKCM | 1 |
p.E1098Q | HNSC | 1 |
p.A295V | SKCM | 1 |
p.D401N | SKCM | 1 |
p.S31P | UCS | 1 |
p.E553K | SKCM | 1 |
p.A1182T | SKCM | 1 |
p.G142R | SKCM | 1 |
p.G1280E | CESC | 1 |
p.E246K | SKCM | 1 |
p.T457I | SKCM | 1 |
p.V906L | LUAD | 1 |
p.E651K | SKCM | 1 |
p.L1248F | BLCA | 1 |
p.W1283C | STAD | 1 |
p.V385M | SKCM | 1 |
p.E725K | SARC | 1 |
p.S157L | SKCM | 1 |
p.F345L | LUAD | 1 |
p.R997Q | LGG | 1 |
p.D621N | SKCM | 1 |
p.E428Q | HNSC | 1 |
p.A701S | HNSC | 1 |
p.G931A | LIHC | 1 |
p.L705M | PAAD | 1 |
p.D340N | STAD | 1 |
p.D358N | SKCM | 1 |
p.E503K | SKCM | 1 |
p.E13D | SKCM | 1 |
p.G704R | SKCM | 1 |
p.M1306L | LGG | 1 |
p.G704E | SKCM | 1 |
p.E503* | LUAD | 1 |
p.K1048N | LUAD | 1 |
p.C326R | UCS | 1 |
p.D632N | SKCM | 1 |
p.A56T | LUAD | 1 |
p.W522* | SKCM | 1 |
p.S1316F | HNSC | 1 |
p.M1229I | SKCM | 1 |
p.R1211Q | SKCM | 1 |
p.S1224F | SKCM | 1 |
p.R1249K | LUAD | 1 |
p.K361* | LIHC | 1 |
p.T33I | SKCM | 1 |
p.R87T | CESC | 1 |
p.P1315L | SKCM | 1 |
p.V901I | STAD | 1 |
p.G931S | LIHC | 1 |
p.E718K | SKCM | 1 |
p.W1283* | SKCM | 1 |
p.E972Q | LUAD | 1 |
p.G609R | SKCM | 1 |
p.G749S | SKCM | 1 |
p.R738K | SKCM | 1 |
p.P674L | LUAD | 1 |
p.D14N | SKCM | 1 |
p.W800S | LUAD | 1 |
p.L631P | LIHC | 1 |
p.E831K | SKCM | 1 |
p.Q1302* | KIRC | 1 |
p.Q538E | LUAD | 1 |
p.V765M | SKCM | 1 |
p.Y965C | SKCM | 1 |
p.E1230K | SKCM | 1 |
p.Q764H | ESCA | 1 |
p.A529V | SKCM | 1 |
p.G633S | SKCM | 1 |
p.W1283X | SKCM | 1 |
p.S99F | SARC | 1 |
p.S69* | CESC | 1 |
p.H237Y | LUAD | 1 |
p.C1185R | SKCM | 1 |
p.E703Q | HNSC | 1 |
p.S1103F | SKCM | 1 |
p.P712S | SKCM | 1 |
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TissGeneCNV for MROH7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MROH7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | NM6777215 | MROH7-TTC4 | chr1:54710266 | chr1:54715822 | |
Chimerdb3.0 | ChiTaRs | NA | BF932930 | ACTG1-MROH7 | chr17:79477407 | chr1:55126838 |
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TissGeneNet for MROH7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MROH7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MROH7 |
TissGeneDrug for MROH7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MROH7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |