TissGeneSummary for KCNF1 |
Gene summary |
Basic gene information | Gene symbol | KCNF1 |
Gene name | potassium voltage-gated channel, subfamily F, member 1 | |
Synonyms | IK8|KCNF|KV5.1|kH1 | |
Cytomap | UCSC genome browser: 2p25 | |
Type of gene | protein-coding | |
RefGenes | NM_002236.4, | |
Description | potassium channel KH1potassium channel Kv5.1potassium voltage-gated channel subfamily F member 1voltage-gated potassium channel subunit Kv5.1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 603787 | |
HGNC : HGNC | ||
Ensembl : ENSG00000162975 | ||
HPRD : 04808 | ||
Vega : OTTHUMG00000119054 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNF1 | |
BioGPS: 3754 | ||
Pathway | NCI Pathway Interaction Database: KCNF1 | |
KEGG: KCNF1 | ||
REACTOME: KCNF1 | ||
Pathway Commons: KCNF1 | ||
Context | iHOP: KCNF1 | |
ligand binding site mutation search in PubMed: KCNF1 | ||
UCL Cancer Institute: KCNF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of KCNF1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.412614318 | -3.462756318 | 2.050142 | 1.25E-05 | 5.15E-05 |
BRCA | 0.357226454 | -1.371087581 | 1.728314035 | 7.50E-10 | 2.70E-09 |
PRAD | -3.265918856 | -1.422113087 | -1.843805769 | 2.43E-12 | 1.16E-10 |
KICH | -3.100554318 | -1.888794318 | -1.21176 | 0.00258 | 0.005174086 |
HNSC | -2.09163348 | -3.151805573 | 1.060172093 | 0.000686 | 0.002449683 |
COAD | -2.275501548 | -0.710824625 | -1.564676923 | 0.000101 | 0.000366376 |
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TissGene-miRNA for KCNF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNF1 |
TissGeneSNV for KCNF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E158K | BLCA | 3 |
p.T312I | LIHC | 2 |
p.E206A | BLCA | 1 |
p.V154L | ESCA | 1 |
p.A251T | STAD | 1 |
p.V168I | HNSC | 1 |
p.T221M | HNSC | 1 |
p.R135C | ESCA | 1 |
p.S177L | LGG | 1 |
p.E136D | PAAD | 1 |
p.R487S | LUAD | 1 |
p.E206K | ESCA | 1 |
p.W169X | SKCM | 1 |
p.V145M | COAD | 1 |
p.R293W | OV | 1 |
p.T381M | LGG | 1 |
p.M345T | STAD | 1 |
p.D375N | SKCM | 1 |
p.E420D | LUAD | 1 |
p.I357N | HNSC | 1 |
p.S434F | SKCM | 1 |
p.T273M | STAD | 1 |
p.D39N | SKCM | 1 |
p.C200R | STAD | 1 |
p.L385F | UCEC | 1 |
p.L248Q | LUSC | 1 |
p.L235P | STAD | 1 |
p.E76K | UCEC | 1 |
p.P478S | LUAD | 1 |
p.S308L | SKCM | 1 |
p.R75C | HNSC | 1 |
p.A422T | UCEC | 1 |
p.R417H | STAD | 1 |
p.S14R | LUSC | 1 |
p.A228S | LUAD | 1 |
p.T221K | HNSC | 1 |
p.E140K | SKCM | 1 |
p.R319H | STAD | 1 |
p.Q34X | COAD | 1 |
p.A185V | COAD | 1 |
p.I294M | BLCA | 1 |
p.N407Y | LUSC | 1 |
p.S269R | LUAD | 1 |
p.H306Q | HNSC | 1 |
p.R417C | HNSC | 1 |
p.N284D | THYM | 1 |
p.E136K | UCEC | 1 |
p.P462L | SKCM | 1 |
p.E91K | SKCM | 1 |
p.P478S | SKCM | 1 |
p.E213K | BLCA | 1 |
p.T234I | COAD | 1 |
p.Q165K | LUAD | 1 |
p.V217L | LUAD | 1 |
p.E439K | READ | 1 |
p.S20N | STAD | 1 |
p.V371I | KIRP | 1 |
p.Q359R | UCEC | 1 |
p.P456H | LUAD | 1 |
p.A156T | STAD | 1 |
p.R278H | LUAD | 1 |
p.D151N | SKCM | 1 |
p.A388T | STAD | 1 |
p.E158K | CESC | 1 |
p.A85T | PRAD | 1 |
p.C393G | SKCM | 1 |
p.F233S | STAD | 1 |
p.I294V | UCEC | 1 |
p.P83L | STAD | 1 |
p.W116* | SKCM | 1 |
p.R144H | STAD | 1 |
p.R81S | SKCM | 1 |
p.Q165R | LUAD | 1 |
p.S445F | SKCM | 1 |
p.W169* | SKCM | 1 |
p.S390I | UCEC | 1 |
p.R417H | BLCA | 1 |
p.D71N | SKCM | 1 |
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TissGeneCNV for KCNF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KCNF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNF1 |
TissGeneDrug for KCNF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |