TissGeneSummary for KCNN1 |
Gene summary |
Basic gene information | Gene symbol | KCNN1 |
Gene name | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 | |
Synonyms | KCa2.1|SK1|SKCA1|hSK1 | |
Cytomap | UCSC genome browser: 19p13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002248.4, | |
Description | small conductance calcium-activated potassium channel protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 602982 | |
HGNC : HGNC | ||
HPRD : 04282 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNN1 | |
BioGPS: 3780 | ||
Pathway | NCI Pathway Interaction Database: KCNN1 | |
KEGG: KCNN1 | ||
REACTOME: KCNN1 | ||
Pathway Commons: KCNN1 | ||
Context | iHOP: KCNN1 | |
ligand binding site mutation search in PubMed: KCNN1 | ||
UCL Cancer Institute: KCNN1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of KCNN1 | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNN1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.675390504 | -1.042267829 | 2.717658333 | 5.67E-16 | 3.05E-15 |
LIHC | -0.400708996 | -1.822420996 | 1.421712 | 2.45E-07 | 1.54E-06 |
LUSC | 0.210783396 | -0.959496996 | 1.170280392 | 5.79E-06 | 1.35E-05 |
KICH | 1.708795004 | -0.927072996 | 2.635868 | 0.000732 | 0.001623066 |
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TissGene-miRNA for KCNN1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNN1 |
TissGeneSNV for KCNN1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A320V | UCEC | 1 |
p.H204R | READ | 1 |
p.R425H | ESCA | 1 |
p.R92H | HNSC | 1 |
p.A491T | UCEC | 1 |
p.G22E | SKCM | 1 |
p.E184K | BLCA | 1 |
p.D416N | SKCM | 1 |
p.S469P | DLBC | 1 |
p.V228L | LUSC | 1 |
p.R105C | PRAD | 1 |
p.Y138N | OV | 1 |
p.S256L | STAD | 1 |
p.D68N | GBM | 1 |
p.V120I | STAD | 1 |
p.R438W | KIRC | 1 |
p.P219L | SKCM | 1 |
p.V244M | KIRC | 1 |
p.W209R | BLCA | 1 |
p.V46L | BLCA | 1 |
p.R212W | BLCA | 1 |
p.H199Y | SKCM | 1 |
p.R271C | COAD | 1 |
p.V120I | BLCA | 1 |
p.T270S | LUAD | 1 |
p.V301M | LGG | 1 |
p.L329I | UCEC | 1 |
p.V186M | PRAD | 1 |
p.K389N | ESCA | 1 |
p.T270A | STAD | 1 |
p.V412L | OV | 1 |
p.Q461X | LIHC | 1 |
p.L286M | PAAD | 1 |
p.R425H | READ | 1 |
p.A394T | UCEC | 1 |
p.S128P | LUSC | 1 |
p.E375K | BLCA | 1 |
p.I405T | LUSC | 1 |
p.V273F | UCEC | 1 |
p.R367W | PAAD | 1 |
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TissGeneCNV for KCNN1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNN1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-44-7670-01A | FAM53B-KCNN1 | In-frame | Chr10:126370176 | Chr19:18099224 |
TCGAfusionPortal | PRADA | OV | TCGA-25-1329-01A | KCNN1-SLC27A1 | NA | Chr19:18100652 | Chr19:17597372 |
TCGAfusionPortal | PRADA | OV | TCGA-25-1329-01A | ARRDC2-KCNN1 | CDS-5UTR | Chr19:18112382 | Chr19:18084617 |
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TissGeneNet for KCNN1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNN1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNN1 |
TissGeneDrug for KCNN1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB01110 | Miconazole | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
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TissGeneDisease for KCNN1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009324 | Ulcerative Colitis | 1 | LHGDN |
umls:C0010346 | Crohn Disease | 1 | LHGDN |