TissGeneSummary for RNF148 |
Gene summary |
Basic gene information | Gene symbol | RNF148 |
Gene name | ring finger protein 148 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7q31.33 | |
Type of gene | protein-coding | |
RefGenes | NM_198085.1, | |
Description | RING finger protein 148 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000235631 | ||
HPRD : 11512 | ||
Vega : OTTHUMG00000157099 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF148 | |
BioGPS: 378925 | ||
Pathway | NCI Pathway Interaction Database: RNF148 | |
KEGG: RNF148 | ||
REACTOME: RNF148 | ||
Pathway Commons: RNF148 | ||
Context | iHOP: RNF148 | |
ligand binding site mutation search in PubMed: RNF148 | ||
UCL Cancer Institute: RNF148 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of RNF148 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for RNF148 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.383410057 | 0.295199747 | -1.678609804 | 4.25E-19 | 4.45E-18 |
KIRP | -1.324279175 | -0.17005105 | -1.154228125 | 4.41E-10 | 4.39E-09 |
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TissGene-miRNA for RNF148 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RNF148 |
TissGeneSNV for RNF148 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M154I | SKCM | 2 |
p.E106K | UCEC | 2 |
p.P141S | SKCM | 2 |
p.R216* | LUAD | 1 |
p.M161I | SKCM | 1 |
p.P287R | LUSC | 1 |
p.D248N | SKCM | 1 |
p.R107C | STAD | 1 |
p.R94W | HNSC | 1 |
p.G34E | SKCM | 1 |
p.G126E | SKCM | 1 |
p.Q133H | LUSC | 1 |
p.E58D | SKCM | 1 |
p.E99* | UCEC | 1 |
p.A152V | LGG | 1 |
p.T214A | LIHC | 1 |
p.E55K | SKCM | 1 |
p.N33D | SKCM | 1 |
p.C284Y | THYM | 1 |
p.L25V | BLCA | 1 |
p.W211* | SKCM | 1 |
p.V127A | UCEC | 1 |
p.V210I | STAD | 1 |
p.R272H | COAD | 1 |
p.D248N | LUSC | 1 |
p.S15L | SKCM | 1 |
p.S66T | LUAD | 1 |
p.Q133* | SKCM | 1 |
p.E106K | COAD | 1 |
p.K122N | BRCA | 1 |
p.N33H | PAAD | 1 |
p.T10M | ESCA | 1 |
p.T222N | LIHC | 1 |
p.A152T | HNSC | 1 |
p.E246K | SKCM | 1 |
p.H65Y | HNSC | 1 |
p.A152T | UCEC | 1 |
p.G17R | SKCM | 1 |
p.R272H | STAD | 1 |
p.V118M | THCA | 1 |
p.G34R | GBM | 1 |
p.S54L | UCEC | 1 |
p.L27H | SKCM | 1 |
p.N43H | STAD | 1 |
p.R225Q | UCEC | 1 |
p.F140L | READ | 1 |
p.A152V | HNSC | 1 |
p.Y206C | LIHC | 1 |
p.F262I | OV | 1 |
p.I302V | HNSC | 1 |
p.Q227E | LUSC | 1 |
p.R272C | BLCA | 1 |
p.G60V | LUAD | 1 |
p.R5K | SKCM | 1 |
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TissGeneCNV for RNF148 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RNF148 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RNF148 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RNF148 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RNF148 |
TissGeneDrug for RNF148 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RNF148 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |