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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KLK1
check button Gene summary
Basic gene informationGene symbolKLK1
Gene namekallikrein 1
SynonymsKLKR|Klk6|hK1
CytomapUCSC genome browser: 19q13.3
Type of geneprotein-coding
RefGenesNM_002257.3,
Descriptionglandular kallikrein 1kallikrein 1, renal/pancreas/salivarykallikrein serine protease 1kallikrein-1kidney/pancreas/salivary gland kallikreintissue kallikrein
Modification date20141207
dbXrefs MIM : 147910
HGNC : HGNC
Ensembl : ENSG00000167748
HPRD : 01003
Vega : OTTHUMG00000182876
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK1
BioGPS: 3816
PathwayNCI Pathway Interaction Database: KLK1
KEGG: KLK1
REACTOME: KLK1
Pathway Commons: KLK1
ContextiHOP: KLK1
ligand binding site mutation search in PubMed: KLK1
UCL Cancer Institute: KLK1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTExTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)KidneyPancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICHPAAD
Reference showing the relevant tissue of KLK1
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for KLK1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
THCA-0.9947286541.656191685-2.6509203391.85E-088.90E-08
KIRC-2.8988622693.083462731-5.9823254.99E-256.04E-24
KIRP-1.2872049784.265610647-5.5528156254.14E-104.18E-09
KICH8.7593383973.3919303975.3674087.55E-083.52E-07
COAD4.203381325.95953132-1.756154.23E-050.000167897


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TissGene-miRNA for KLK1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for KLK1
TissGeneSNV for KLK1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D183NSKCM1
p.H87NLUAD1
p.P234LOV1
p.E46QBLCA1
p.G51WLUAD1
p.S127TPAAD1
p.V245ILIHC1
p.D183ALGG1
p.G99*LUAD1
p.Q225XSTAD1
p.H119NLUSC1
p.D81ALGG1
p.A259VCOAD1
p.E158DLUAD1
p.C50FLUAD1
p.V92ILGG1
p.Q225*STAD1
p.S229TPAAD1
p.D111NSKCM1
p.E46KSKCM1
p.S262TCOAD1
p.V233DSTAD1
p.A259VUCEC1
p.D81NSKCM1
p.V5FLUSC1
p.E148KSKCM1
p.K186ECOAD1
p.P129RLUAD1
p.P234AHNSC1
p.T110ILUAD1
p.E255KSTAD1
p.P27RLUAD1
p.F45LLUAD1
p.H7PSKCM1
p.G99EESCA1
p.E255KSKCM1
p.E153KSKCM1
p.E164DUCEC1
p.S16TLIHC1
p.G212SLIHC1
p.G16SSKCM1
p.P132AHNSC1
p.R24WHNSC1
p.H98YUCEC1
p.E148QBLCA1
p.G48RLUAD1
p.G52DTHYM1
p.T8ILUAD1


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TissGeneCNV for KLK1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for KLK1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACB985286KLK1-EFHD2chr19:51322551chr1:15756752


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TissGeneNet for KLK1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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COAD (tumor)COAD (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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HNSC (tumor)HNSC (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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KICH (tumor)KICH (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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KIRC (tumor)KIRC (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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KIRP (tumor)KIRP (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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LIHC (tumor)LIHC (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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LUAD (tumor)LUAD (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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LUSC (tumor)LUSC (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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PRAD (tumor)PRAD (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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STAD (tumor)STAD (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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THCA (tumor)THCA (normal)
KLK1, SERPINA5, KNG1, SERPINA4 (tumor)KLK1, SERPINA5, KNG1, SERPINA4 (normal)
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TissGeneProg for KLK1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for KLK1
TissGeneDrug for KLK1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for KLK1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease20BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0022116Ischemia9BeFree,LHGDN
umls:C0029925Ovarian Carcinoma9BeFree
umls:C1140680Malignant neoplasm of ovary7BeFree
umls:C0027051Myocardial Infarction6BeFree,CTD_human
umls:C0022661Kidney Failure, Chronic5BeFree,GAD,LHGDN
umls:C0677886Epithelial ovarian cancer5BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0010054Coronary Arteriosclerosis4BeFree
umls:C0011849Diabetes Mellitus4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C0007102Malignant tumor of colon3BeFree
umls:C0011847Diabetes3BeFree
umls:C0022658Kidney Diseases3BeFree
umls:C0035078Kidney Failure3BeFree
umls:C0085580Essential Hypertension3BeFree
umls:C0151744Myocardial Ischemia3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree,GAD
umls:C0699790Colon Carcinoma3BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011881Diabetic Nephropathy2BeFree,CTD_human
umls:C0021368Inflammation2LHGDN,RGD
umls:C0022660Kidney Failure, Acute2BeFree
umls:C0024141Lupus Erythematosus, Systemic2BeFree
umls:C0024143Lupus Nephritis2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0038454Cerebrovascular accident2BeFree
umls:C0403447Chronic Kidney Insufficiency2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0853897Diabetic Cardiomyopathies2BeFree,CTD_human
umls:C0878544Cardiomyopathies2LHGDN
umls:C1527249Colorectal Cancer2BeFree
umls:C1956346Coronary Artery Disease2BeFree,GAD
umls:C0001418Adenocarcinoma1BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0003486Aortic Aneurysm1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0004096Asthma1BeFree
umls:C0007222Cardiovascular Diseases1GAD
umls:C0007766Intracranial Aneurysm1GAD
umls:C0007785Cerebral Infarction1BeFree
umls:C0008677Bronchitis, Chronic1BeFree
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009375Colonic Neoplasms1LHGDN
umls:C0010068Coronary heart disease1BeFree
umls:C0010278Craniosynostosis1BeFree
umls:C0010346Crohn Disease1BeFree
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0011853Diabetes Mellitus, Experimental1RGD
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0013595Eczema1BeFree
umls:C0014556Epilepsy, Temporal Lobe1BeFree
umls:C0016059Fibrosis1CTD_human
umls:C0017636Glioblastoma1BeFree
umls:C0020459Hyperinsulinism1BeFree
umls:C0020544Renal hypertension1BeFree
umls:C0020545Hypertension, Renovascular1BeFree
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0025286Meningioma1BeFree
umls:C0027126Myotonic Dystrophy1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0028754Obesity1BeFree
umls:C0030305Pancreatitis1RGD
umls:C0030920Peptic Ulcer1BeFree
umls:C0032002Pituitary Diseases1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0032927Precancerous Conditions1BeFree
umls:C0033375Prolactinoma1BeFree
umls:C0033860Psoriasis1BeFree
umls:C0035126Reperfusion Injury1RGD
umls:C0038358Gastric ulcer1BeFree
umls:C0042580Vesico-Ureteral Reflux1BeFree,GAD
umls:C0086942Rous Sarcoma1BeFree
umls:C0155626Acute myocardial infarction1BeFree
umls:C0162871Aortic Aneurysm, Abdominal1BeFree
umls:C0178664Glomerulosclerosis (disorder)1BeFree
umls:C0178874Tumor Progression1BeFree
umls:C0262587Parathyroid Adenoma1BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0403622Primary vesicoureteric reflux1BeFree
umls:C0410226Congenital Myotonic Dystrophy1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0595862Vasodilation disorder1GAD
umls:C0596263Carcinogenesis1BeFree
umls:C0740391Middle Cerebral Artery Occlusion1BeFree
umls:C0747845early pregnancy1BeFree
umls:C0852036Pregnancy associated hypertension1LHGDN
umls:C0917798Cerebral Ischemia1BeFree
umls:C0919267ovarian neoplasm1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C0948089Acute Coronary Syndrome1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1397307Cardiac fibrosis1BeFree
umls:C1504404Hippocampal sclerosis1BeFree
umls:C1527390Neoplasms, Intracranial1BeFree
umls:C1559271Non-Malignant Ascites Adverse Event1BeFree
umls:C1561643Chronic Kidney Diseases1BeFree
umls:C1853578Neuroferritinopathy1BeFree
umls:C1879286Hereditary bundle branch system defect1BeFree
umls:C2316810Chronic kidney disease stage 51BeFree
umls:C2609414Acute kidney injury1CTD_human
umls:C2931852Clear-cell metastatic renal cell carcinoma1BeFree
umls:C2937358Cerebral Hemorrhage1GAD
umls:C2945695Limb ischemia1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree
umls:C3536572Hypertensive end stage renal disease1BeFree
umls:C1835808Kallikrein, Decreased Urinary Activity of0CLINVAR