TissGeneSummary for KLK1 |
Gene summary |
Basic gene information | Gene symbol | KLK1 |
Gene name | kallikrein 1 | |
Synonyms | KLKR|Klk6|hK1 | |
Cytomap | UCSC genome browser: 19q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_002257.3, | |
Description | glandular kallikrein 1kallikrein 1, renal/pancreas/salivarykallikrein serine protease 1kallikrein-1kidney/pancreas/salivary gland kallikreintissue kallikrein | |
Modification date | 20141207 | |
dbXrefs | MIM : 147910 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167748 | ||
HPRD : 01003 | ||
Vega : OTTHUMG00000182876 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLK1 | |
BioGPS: 3816 | ||
Pathway | NCI Pathway Interaction Database: KLK1 | |
KEGG: KLK1 | ||
REACTOME: KLK1 | ||
Pathway Commons: KLK1 | ||
Context | iHOP: KLK1 | |
ligand binding site mutation search in PubMed: KLK1 | ||
UCL Cancer Institute: KLK1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTExTiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPAAD | |
Reference showing the relevant tissue of KLK1 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KLK1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.994728654 | 1.656191685 | -2.650920339 | 1.85E-08 | 8.90E-08 |
KIRC | -2.898862269 | 3.083462731 | -5.982325 | 4.99E-25 | 6.04E-24 |
KIRP | -1.287204978 | 4.265610647 | -5.552815625 | 4.14E-10 | 4.18E-09 |
KICH | 8.759338397 | 3.391930397 | 5.367408 | 7.55E-08 | 3.52E-07 |
COAD | 4.20338132 | 5.95953132 | -1.75615 | 4.23E-05 | 0.000167897 |
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TissGene-miRNA for KLK1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLK1 |
TissGeneSNV for KLK1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D183N | SKCM | 1 |
p.H87N | LUAD | 1 |
p.P234L | OV | 1 |
p.E46Q | BLCA | 1 |
p.G51W | LUAD | 1 |
p.S127T | PAAD | 1 |
p.V245I | LIHC | 1 |
p.D183A | LGG | 1 |
p.G99* | LUAD | 1 |
p.Q225X | STAD | 1 |
p.H119N | LUSC | 1 |
p.D81A | LGG | 1 |
p.A259V | COAD | 1 |
p.E158D | LUAD | 1 |
p.C50F | LUAD | 1 |
p.V92I | LGG | 1 |
p.Q225* | STAD | 1 |
p.S229T | PAAD | 1 |
p.D111N | SKCM | 1 |
p.E46K | SKCM | 1 |
p.S262T | COAD | 1 |
p.V233D | STAD | 1 |
p.A259V | UCEC | 1 |
p.D81N | SKCM | 1 |
p.V5F | LUSC | 1 |
p.E148K | SKCM | 1 |
p.K186E | COAD | 1 |
p.P129R | LUAD | 1 |
p.P234A | HNSC | 1 |
p.T110I | LUAD | 1 |
p.E255K | STAD | 1 |
p.P27R | LUAD | 1 |
p.F45L | LUAD | 1 |
p.H7P | SKCM | 1 |
p.G99E | ESCA | 1 |
p.E255K | SKCM | 1 |
p.E153K | SKCM | 1 |
p.E164D | UCEC | 1 |
p.S16T | LIHC | 1 |
p.G212S | LIHC | 1 |
p.G16S | SKCM | 1 |
p.P132A | HNSC | 1 |
p.R24W | HNSC | 1 |
p.H98Y | UCEC | 1 |
p.E148Q | BLCA | 1 |
p.G48R | LUAD | 1 |
p.G52D | THYM | 1 |
p.T8I | LUAD | 1 |
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TissGeneCNV for KLK1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLK1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB985286 | KLK1-EFHD2 | chr19:51322551 | chr1:15756752 |
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TissGeneNet for KLK1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLK1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLK1 |
TissGeneDrug for KLK1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLK1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020538 | Hypertensive disease | 20 | BeFree,CTD_human,GAD,LHGDN,RGD |
umls:C0022116 | Ischemia | 9 | BeFree,LHGDN |
umls:C0029925 | Ovarian Carcinoma | 9 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 7 | BeFree |
umls:C0027051 | Myocardial Infarction | 6 | BeFree,CTD_human |
umls:C0022661 | Kidney Failure, Chronic | 5 | BeFree,GAD,LHGDN |
umls:C0677886 | Epithelial ovarian cancer | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0010054 | Coronary Arteriosclerosis | 4 | BeFree |
umls:C0011849 | Diabetes Mellitus | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C0007102 | Malignant tumor of colon | 3 | BeFree |
umls:C0011847 | Diabetes | 3 | BeFree |
umls:C0022658 | Kidney Diseases | 3 | BeFree |
umls:C0035078 | Kidney Failure | 3 | BeFree |
umls:C0085580 | Essential Hypertension | 3 | BeFree |
umls:C0151744 | Myocardial Ischemia | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree,GAD |
umls:C0699790 | Colon Carcinoma | 3 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0011881 | Diabetic Nephropathy | 2 | BeFree,CTD_human |
umls:C0021368 | Inflammation | 2 | LHGDN,RGD |
umls:C0022660 | Kidney Failure, Acute | 2 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
umls:C0024143 | Lupus Nephritis | 2 | BeFree |
umls:C0036421 | Systemic Scleroderma | 2 | BeFree |
umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
umls:C0403447 | Chronic Kidney Insufficiency | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0853897 | Diabetic Cardiomyopathies | 2 | BeFree,CTD_human |
umls:C0878544 | Cardiomyopathies | 2 | LHGDN |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0003486 | Aortic Aneurysm | 1 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
umls:C0004096 | Asthma | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0007766 | Intracranial Aneurysm | 1 | GAD |
umls:C0007785 | Cerebral Infarction | 1 | BeFree |
umls:C0008677 | Bronchitis, Chronic | 1 | BeFree |
umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0010278 | Craniosynostosis | 1 | BeFree |
umls:C0010346 | Crohn Disease | 1 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0013595 | Eczema | 1 | BeFree |
umls:C0014556 | Epilepsy, Temporal Lobe | 1 | BeFree |
umls:C0016059 | Fibrosis | 1 | CTD_human |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0020544 | Renal hypertension | 1 | BeFree |
umls:C0020545 | Hypertension, Renovascular | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
umls:C0025286 | Meningioma | 1 | BeFree |
umls:C0027126 | Myotonic Dystrophy | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0030305 | Pancreatitis | 1 | RGD |
umls:C0030920 | Peptic Ulcer | 1 | BeFree |
umls:C0032002 | Pituitary Diseases | 1 | BeFree |
umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0033375 | Prolactinoma | 1 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0035126 | Reperfusion Injury | 1 | RGD |
umls:C0038358 | Gastric ulcer | 1 | BeFree |
umls:C0042580 | Vesico-Ureteral Reflux | 1 | BeFree,GAD |
umls:C0086942 | Rous Sarcoma | 1 | BeFree |
umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
umls:C0162871 | Aortic Aneurysm, Abdominal | 1 | BeFree |
umls:C0178664 | Glomerulosclerosis (disorder) | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0262587 | Parathyroid Adenoma | 1 | BeFree |
umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 1 | BeFree |
umls:C0403622 | Primary vesicoureteric reflux | 1 | BeFree |
umls:C0410226 | Congenital Myotonic Dystrophy | 1 | BeFree |
umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0595862 | Vasodilation disorder | 1 | GAD |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0740391 | Middle Cerebral Artery Occlusion | 1 | BeFree |
umls:C0747845 | early pregnancy | 1 | BeFree |
umls:C0852036 | Pregnancy associated hypertension | 1 | LHGDN |
umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | BeFree |
umls:C0948008 | Ischemic stroke | 1 | BeFree |
umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
umls:C1397307 | Cardiac fibrosis | 1 | BeFree |
umls:C1504404 | Hippocampal sclerosis | 1 | BeFree |
umls:C1527390 | Neoplasms, Intracranial | 1 | BeFree |
umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
umls:C1561643 | Chronic Kidney Diseases | 1 | BeFree |
umls:C1853578 | Neuroferritinopathy | 1 | BeFree |
umls:C1879286 | Hereditary bundle branch system defect | 1 | BeFree |
umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
umls:C2609414 | Acute kidney injury | 1 | CTD_human |
umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 1 | BeFree |
umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
umls:C2945695 | Limb ischemia | 1 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
umls:C3536572 | Hypertensive end stage renal disease | 1 | BeFree |
umls:C1835808 | Kallikrein, Decreased Urinary Activity of | 0 | CLINVAR |