TissGeneSummary for KRT14 |
Gene summary |
Basic gene information | Gene symbol | KRT14 |
Gene name | keratin 14 | |
Synonyms | CK14|EBS3|EBS4|K14|NFJ | |
Cytomap | UCSC genome browser: 17q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_000526.4, | |
Description | CK-14cytokeratin 14cytokeratin-14keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)keratin, type I cytoskeletal 14keratin-14 | |
Modification date | 20141219 | |
dbXrefs | MIM : 148066 | |
HGNC : HGNC | ||
Ensembl : ENSG00000186847 | ||
HPRD : 01017 | ||
Vega : OTTHUMG00000133426 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT14 | |
BioGPS: 3861 | ||
Pathway | NCI Pathway Interaction Database: KRT14 | |
KEGG: KRT14 | ||
REACTOME: KRT14 | ||
Pathway Commons: KRT14 | ||
Context | iHOP: KRT14 | |
ligand binding site mutation search in PubMed: KRT14 | ||
UCL Cancer Institute: KRT14 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCASKCM | |
Reference showing the relevant tissue of KRT14 | Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). Liu W, Shaver TM, Balasa A, Ljungberg MC, Wang X, Wen S, Nguyen H, Van den Veyver IB. PLoS One. 2012;7(3):e32331. doi: 10.1371/journal.pone.0032331. Epub 2012 Mar 6. (pmid:22412863) go to articleUroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Kidney Int. 2016 Mar;89(3):612-24. doi: 10.1016/j.kint.2015.11.017. Epub 2015 Dec 23. (pmid:26880456) go to article | |
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0007568 | aging | 21916889 | GO:0042633 | hair cycle | 21916889 | GO:0007568 | aging | 21916889 | GO:0042633 | hair cycle | 21916889 |
Top |
TissGeneExp for KRT14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 2.231287594 | 6.319381454 | -4.08809386 | 1.37E-17 | 8.23E-17 |
LUAD | -2.673355388 | -4.827470905 | 2.154115517 | 2.05E-06 | 6.51E-06 |
LUSC | 5.368636769 | -2.06651029 | 7.435147059 | 1.69E-19 | 1.86E-18 |
THCA | -2.654623185 | -4.708616405 | 2.05399322 | 4.76E-06 | 1.62E-05 |
COAD | -5.289674619 | -4.252816927 | -1.036857692 | 0.00661 | 0.015293041 |
BLCA | 3.042755138 | -1.556086967 | 4.598842105 | 0.000774 | 0.005718857 |
PRAD | 2.105986919 | 3.724663843 | -1.618676923 | 2.59E-05 | 0.000128411 |
Top |
TissGene-miRNA for KRT14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for KRT14 |
TissGeneSNV for KRT14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R56C | DLBC | 1 |
p.E381K | SKCM | 1 |
p.D301H | HNSC | 1 |
p.D234E | LUAD | 1 |
p.A424T | LGG | 1 |
p.S13F | SKCM | 1 |
p.E465K | READ | 1 |
p.E304K | SKCM | 1 |
p.R282H | LUAD | 1 |
p.K399N | LUAD | 1 |
p.E271K | HNSC | 1 |
p.F73Y | COAD | 1 |
p.R222C | MESO | 1 |
p.R288C | STAD | 1 |
p.K203T | UCEC | 1 |
p.N340K | ESCA | 1 |
p.R6C | ACC | 1 |
p.R288H | STAD | 1 |
p.R56H | UCEC | 1 |
p.V133M | LIHC | 1 |
p.V34I | LUAD | 1 |
p.R194H | GBM | 1 |
p.S241I | BLCA | 1 |
p.F306L | READ | 1 |
p.D199E | PRAD | 1 |
p.T180K | COAD | 1 |
p.E342K | SARC | 1 |
p.V452I | PAAD | 1 |
p.S443F | OV | 1 |
p.V145L | LUSC | 1 |
p.D234Y | HNSC | 1 |
p.Q152E | ACC | 1 |
p.G266A | HNSC | 1 |
p.E333K | LUAD | 1 |
p.E286K | UCEC | 1 |
p.E303K | BLCA | 1 |
p.R261K | HNSC | 1 |
p.M376I | HNSC | 1 |
p.K132N | SARC | 1 |
p.Y69F | BRCA | 1 |
p.S74I | LUAD | 1 |
p.K363T | SKCM | 1 |
p.K167R | LUAD | 1 |
p.R155Q | UCEC | 1 |
p.F166L | HNSC | 1 |
p.R173M | UCEC | 1 |
p.Y204C | BRCA | 1 |
p.E296D | UCEC | 1 |
p.G93C | HNSC | 1 |
p.E316K | HNSC | 1 |
p.R222H | UCEC | 1 |
p.R439T | LUSC | 1 |
p.G23D | SKCM | 1 |
p.A94T | COAD | 1 |
p.N140S | LUAD | 1 |
p.M14I | SKCM | 1 |
p.R469C | KIRP | 1 |
p.D273N | LIHC | 1 |
p.R134H | STAD | 1 |
p.S432F | LUAD | 1 |
p.R201C | UCEC | 1 |
p.E286* | LUSC | 1 |
p.E207K | UCEC | 1 |
p.D440N | SARC | 1 |
Top |
TissGeneCNV for KRT14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for KRT14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-QQ-A5VB-01A | BNC2-KRT14 | Out-of-Frame | chr9:16727794 | chr17:39739392 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CQ-6229-01A | KRT14-CYP2C18 | 3UTR-CDS | Chr17:39738531 | Chr10:96447527 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CR-7382-01A | KRT14-ARFGEF2 | 3UTR-CDS | Chr17:39738531 | Chr20:47615777 |
Top |
TissGeneNet for KRT14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for KRT14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for KRT14 |
TissGeneDrug for KRT14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for KRT14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0079298 | Epidermolysis Bullosa Simplex | 56 | BeFree,CTD_human,LHGDN |
umls:C0079295 | Epidermolysis Bullosa Herpetiformis Dowling-Meara | 14 | BeFree,CLINVAR,MGD,ORPHANET,UNIPROT |
umls:C0079299 | Epidermolysis Bullosa Simplex Kobner | 11 | BeFree,CLINVAR,ORPHANET,UNIPROT |
umls:C0080333 | Weber-Cockayne Syndrome | 11 | CLINVAR,ORPHANET,UNIPROT |
umls:C0007137 | Squamous cell carcinoma | 8 | BeFree,CTD_human |
umls:C0678222 | Breast Carcinoma | 7 | BeFree |
umls:C0014527 | Epidermolysis Bullosa | 5 | BeFree,LHGDN |
umls:C0037274 | Dermatologic disorders | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
umls:C0279626 | Squamous cell carcinoma of esophagus | 3 | BeFree,CTD_human |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0596321 | Chemical Carcinogenesis | 3 | BeFree |
umls:C0030354 | Papilloma | 2 | BeFree |
umls:C0033860 | Psoriasis | 2 | BeFree |
umls:C0037277 | Skin Diseases, Genetic | 2 | BeFree |
umls:C0343111 | Naegeli syndrome | 2 | BeFree,CLINVAR,CTD_human,ORPHANET |
umls:C0406778 | Dermatopathia pigmentosa reticularis | 2 | BeFree,CLINVAR,CTD_human,ORPHANET |
umls:C0432315 | Epidermolysis bullosa simplex herpetiformis | 2 | BeFree |
umls:C0870082 | Hyperkeratosis | 2 | BeFree |
umls:C3539878 | Triple Negative Breast Neoplasms | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | BeFree,LHGDN |
umls:C0004779 | Basal Cell Nevus Syndrome | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
umls:C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0007873 | Uterine Cervical Neoplasm | 1 | BeFree |
umls:C0013575 | Ectodermal Dysplasia | 1 | BeFree,LHGDN |
umls:C0014859 | Esophageal Neoplasms | 1 | RGD |
umls:C0019163 | Hepatitis B | 1 | BeFree |
umls:C0019196 | Hepatitis C | 1 | BeFree |
umls:C0024899 | Mastocytosis | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | RGD |
umls:C0030436 | Parakeratosis | 1 | RGD |
umls:C0032927 | Precancerous Conditions | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0036323 | Schistosomiasis | 1 | BeFree |
umls:C0040411 | Tongue Neoplasms | 1 | CTD_human |
umls:C0040997 | Trigeminal Neuralgia | 1 | BeFree |
umls:C0042111 | Urticaria Pigmentosa | 1 | BeFree |
umls:C0079153 | Hyperkeratosis, Epidermolytic | 1 | BeFree |
umls:C0205874 | Papilloma, Squamous Cell | 1 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 1 | BeFree |
umls:C0268375 | Autosomal dominant epidermolysis bullosa simplex | 1 | BeFree |
umls:C0279671 | Cervical Squamous Cell Carcinoma | 1 | BeFree |
umls:C0282612 | Prostatic Intraepithelial Neoplasias | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0333873 | Squamous intraepithelial lesion | 1 | BeFree |
umls:C0343110 | Epidermolytic palmoplantar keratoderma of Vorner | 1 | BeFree |
umls:C0406707 | Basan syndrome | 1 | BeFree |
umls:C0549567 | Pigmentation Disorders | 1 | CTD_human |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0856825 | Acute GVH disease | 1 | BeFree |
umls:C1270972 | Mild cognitive disorder | 1 | BeFree |
umls:C1334274 | Invasive Carcinoma | 1 | BeFree |
umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1510885 | Angiogenic Switch | 1 | BeFree |
umls:C2145472 | Urothelial Carcinoma | 1 | BeFree |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
umls:C3715082 | EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 1 | 1 | MGD,ORPHANET,UNIPROT |
umls:C0432316 | Epidermolysis bullosa simplex with mottled pigmentation | 0 | ORPHANET |
umls:C1832926 | EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder) | 0 | CLINVAR,CTD_human |