TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for KRT14
check button Gene summary
Basic gene informationGene symbolKRT14
Gene namekeratin 14
SynonymsCK14|EBS3|EBS4|K14|NFJ
CytomapUCSC genome browser: 17q21.2
Type of geneprotein-coding
RefGenesNM_000526.4,
DescriptionCK-14cytokeratin 14cytokeratin-14keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)keratin, type I cytoskeletal 14keratin-14
Modification date20141219
dbXrefs MIM : 148066
HGNC : HGNC
Ensembl : ENSG00000186847
HPRD : 01017
Vega : OTTHUMG00000133426
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KRT14
BioGPS: 3861
PathwayNCI Pathway Interaction Database: KRT14
KEGG: KRT14
REACTOME: KRT14
Pathway Commons: KRT14
ContextiHOP: KRT14
ligand binding site mutation search in PubMed: KRT14
UCL Cancer Institute: KRT14
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)BladderSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)BLCASKCM
Reference showing the relevant tissue of KRT14Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). Liu W, Shaver TM, Balasa A, Ljungberg MC, Wang X, Wen S, Nguyen H, Van den Veyver IB. PLoS One. 2012;7(3):e32331. doi: 10.1371/journal.pone.0032331. Epub 2012 Mar 6. (pmid:22412863)
go to articleUroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Kidney Int. 2016 Mar;89(3):612-24. doi: 10.1016/j.kint.2015.11.017. Epub 2015 Dec 23. (pmid:26880456)
go to article
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007568aging21916889
GO:0042633hair cycle21916889
GO:0007568aging21916889
GO:0042633hair cycle21916889


Top
TissGeneExp for KRT14

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA2.2312875946.319381454-4.088093861.37E-178.23E-17
LUAD-2.673355388-4.8274709052.1541155172.05E-066.51E-06
LUSC5.368636769-2.066510297.4351470591.69E-191.86E-18
THCA-2.654623185-4.7086164052.053993224.76E-061.62E-05
COAD-5.289674619-4.252816927-1.0368576920.006610.015293041
BLCA3.042755138-1.5560869674.5988421050.0007740.005718857
PRAD2.1059869193.724663843-1.6186769232.59E-050.000128411


Top
TissGene-miRNA for KRT14

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for KRT14
TissGeneSNV for KRT14

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R56CDLBC1
p.E381KSKCM1
p.D301HHNSC1
p.D234ELUAD1
p.A424TLGG1
p.S13FSKCM1
p.E465KREAD1
p.E304KSKCM1
p.R282HLUAD1
p.K399NLUAD1
p.E271KHNSC1
p.F73YCOAD1
p.R222CMESO1
p.R288CSTAD1
p.K203TUCEC1
p.N340KESCA1
p.R6CACC1
p.R288HSTAD1
p.R56HUCEC1
p.V133MLIHC1
p.V34ILUAD1
p.R194HGBM1
p.S241IBLCA1
p.F306LREAD1
p.D199EPRAD1
p.T180KCOAD1
p.E342KSARC1
p.V452IPAAD1
p.S443FOV1
p.V145LLUSC1
p.D234YHNSC1
p.Q152EACC1
p.G266AHNSC1
p.E333KLUAD1
p.E286KUCEC1
p.E303KBLCA1
p.R261KHNSC1
p.M376IHNSC1
p.K132NSARC1
p.Y69FBRCA1
p.S74ILUAD1
p.K363TSKCM1
p.K167RLUAD1
p.R155QUCEC1
p.F166LHNSC1
p.R173MUCEC1
p.Y204CBRCA1
p.E296DUCEC1
p.G93CHNSC1
p.E316KHNSC1
p.R222HUCEC1
p.R439TLUSC1
p.G23DSKCM1
p.A94TCOAD1
p.N140SLUAD1
p.M14ISKCM1
p.R469CKIRP1
p.D273NLIHC1
p.R134HSTAD1
p.S432FLUAD1
p.R201CUCEC1
p.E286*LUSC1
p.E207KUCEC1
p.D440NSARC1


Top
TissGeneCNV for KRT14

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for KRT14

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanSARCTCGA-QQ-A5VB-01ABNC2-KRT14Out-of-Framechr9:16727794chr17:39739392
TCGAfusionPortalPRADAHNSCTCGA-CQ-6229-01AKRT14-CYP2C183UTR-CDSChr17:39738531Chr10:96447527
TCGAfusionPortalPRADAHNSCTCGA-CR-7382-01AKRT14-ARFGEF23UTR-CDSChr17:39738531Chr20:47615777


Top
TissGeneNet for KRT14

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
KRT14, TP63, ZAP70, CUL2, APC, TFAP2A, SYK, CUL1, COPS5, PTEN, PITX3, ALB, NEDD8, HSPA5, TCHP, POU5F1, TFAP2C, DST, KRT5, TFAP2B, PKP1 (tumor)KRT14, TP63, ZAP70, CAND1, CUL2, APC, MDM2, CUL4B, SYK, CUL3, COPS5, ALB, EGFR, SUMO3, POU5F1, TRADD, TFAP2C, DST, KRT5, TFAP2B, PKP1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
KRT14, TP63, CUL5, TFAP2A, UBC, MDM2, CUL4B, SYK, CUL3, SUMO1, CUL1, COPS5, PTEN, HSPA5, SUMO3, TCHP, POU5F1, TRADD, TFAP2C, TFAP2B, NCR2 (tumor)KRT14, TP63, ZAP70, CAND1, APC, TFAP2A, UBC, MDM2, CUL4B, SYK, CUL1, PITX3, ALB, NEDD8, HSPA5, SIRPB1, TFAP2C, DST, KRT5, TREM1, PKP1 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
KRT14, TP63, ZAP70, CAND1, CUL5, CUL2, TFAP2A, UBC, SUMO2, SYK, PTEN, NEDD8, HSPA5, SUMO3, TCHP, TRADD, TFAP2C, KRT5, TFAP2B, PKP1, NCR2 (tumor)KRT14, TP63, ZAP70, TFAP2A, UBC, MDM2, CUL4B, COPS5, PTEN, EGFR, NEDD8, HSPA5, POU5F1, TRADD, SIRPB1, TFAP2C, DST, KRT5, TREM1, TFAP2B, PKP1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
KRT14, TP63, CAND1, CUL5, APC, UBC, MDM2, SUMO2, CUL3, SUMO1, CUL1, COPS5, ALB, NEDD8, HSPA5, SUMO3, TCHP, POU5F1, TRADD, DST, PKP1 (tumor)KRT14, TP63, CAND1, CUL5, CUL2, TFAP2A, SUMO2, CUL4B, CUL3, PITX3, EGFR, NEDD8, HSPA5, TCHP, TRADD, SIRPB1, TFAP2C, DST, KRT5, TREM1, PKP1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
KRT14, TP63, ZAP70, CUL5, CUL2, UBC, MDM2, CUL4B, CUL3, SUMO1, CUL1, COPS5, ALB, HSPA5, SUMO3, POU5F1, TRADD, SIRPB1, KRT5, TFAP2B, NCR2 (tumor)KRT14, TP63, ZAP70, CAND1, CUL5, CUL2, APC, TFAP2A, UBC, SUMO2, CUL4B, CUL3, EGFR, NEDD8, TCHP, TRADD, SIRPB1, TFAP2C, KRT5, TFAP2B, PKP1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
KRT14, TP63, CAND1, CUL5, APC, TFAP2A, UBC, CUL4B, SYK, SUMO1, CUL1, COPS5, PTEN, EGFR, HSPA5, TCHP, POU5F1, TFAP2C, DST, KRT5, TREM1 (tumor)KRT14, TP63, CAND1, APC, TFAP2A, UBC, MDM2, CUL4B, CUL3, CUL1, PTEN, HSPA5, SUMO3, POU5F1, TRADD, TFAP2C, KRT5, TREM1, TFAP2B, PKP1, NCR2 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
KRT14, TP63, CUL5, CUL2, APC, TFAP2A, CUL4B, CUL1, COPS5, ALB, NEDD8, HSPA5, SUMO3, POU5F1, TFAP2C, DST, KRT5, TREM1, TFAP2B, PKP1, NCR2 (tumor)KRT14, TP63, ZAP70, TFAP2A, UBC, MDM2, SUMO2, CUL4B, SYK, CUL3, PITX3, ALB, EGFR, NEDD8, POU5F1, SIRPB1, TFAP2C, KRT5, TREM1, TFAP2B, PKP1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
KRT14, TP63, CAND1, CUL2, APC, TFAP2A, UBC, MDM2, CUL4B, SYK, CUL3, PTEN, ALB, EGFR, HSPA5, TRADD, SIRPB1, TFAP2C, DST, KRT5, TFAP2B (tumor)KRT14, TP63, CAND1, CUL5, TFAP2A, UBC, MDM2, CUL4B, CUL3, SUMO1, COPS5, PTEN, PITX3, EGFR, HSPA5, SUMO3, TCHP, SIRPB1, DST, KRT5, PKP1 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
KRT14, TP63, ZAP70, CAND1, CUL5, CUL2, TFAP2A, UBC, MDM2, SUMO2, CUL4B, SUMO1, COPS5, PTEN, ALB, EGFR, NEDD8, TRADD, KRT5, TFAP2B, PKP1 (tumor)KRT14, TP63, ZAP70, APC, TFAP2A, UBC, MDM2, SUMO2, CUL4B, SUMO1, PITX3, EGFR, NEDD8, HSPA5, TRADD, TFAP2C, DST, KRT5, TREM1, TFAP2B, PKP1 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
KRT14, TP63, ZAP70, CUL2, TFAP2A, CUL4B, SUMO1, COPS5, PTEN, ALB, HSPA5, SUMO3, TCHP, POU5F1, TRADD, TFAP2C, DST, KRT5, TREM1, TFAP2B, PKP1 (tumor)KRT14, TP63, ZAP70, CAND1, CUL5, CUL2, TFAP2A, UBC, SUMO2, CUL4B, SYK, CUL3, COPS5, PTEN, ALB, POU5F1, TRADD, TFAP2C, DST, KRT5, PKP1 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
KRT14, TP63, ZAP70, CAND1, APC, TFAP2A, UBC, MDM2, CUL4B, CUL3, ALB, EGFR, SUMO3, TCHP, SIRPB1, TFAP2C, DST, KRT5, TREM1, TFAP2B, PKP1 (tumor)KRT14, TP63, ZAP70, CUL2, TFAP2A, UBC, SUMO2, CUL4B, SUMO1, CUL1, PTEN, PITX3, EGFR, NEDD8, POU5F1, SIRPB1, TFAP2C, DST, KRT5, TFAP2B, PKP1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
KRT14, TP63, ZAP70, CUL5, CUL2, TFAP2A, UBC, SYK, SUMO1, CUL1, COPS5, ALB, EGFR, POU5F1, TRADD, SIRPB1, KRT5, TREM1, TFAP2B, PKP1, NCR2 (tumor)KRT14, TP63, ZAP70, CUL5, CUL2, APC, TFAP2A, SUMO2, CUL4B, SYK, COPS5, PITX3, SUMO3, TCHP, TRADD, SIRPB1, TFAP2C, DST, KRT5, TREM1, PKP1 (normal)
bullet pointbullet point


Top
TissGeneProg for KRT14

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for KRT14
TissGeneDrug for KRT14

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for KRT14

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0079298Epidermolysis Bullosa Simplex56BeFree,CTD_human,LHGDN
umls:C0079295Epidermolysis Bullosa Herpetiformis Dowling-Meara14BeFree,CLINVAR,MGD,ORPHANET,UNIPROT
umls:C0079299Epidermolysis Bullosa Simplex Kobner11BeFree,CLINVAR,ORPHANET,UNIPROT
umls:C0080333Weber-Cockayne Syndrome11CLINVAR,ORPHANET,UNIPROT
umls:C0007137Squamous cell carcinoma8BeFree,CTD_human
umls:C0678222Breast Carcinoma7BeFree
umls:C0014527Epidermolysis Bullosa5BeFree,LHGDN
umls:C0037274Dermatologic disorders5BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0279626Squamous cell carcinoma of esophagus3BeFree,CTD_human
umls:C0596263Carcinogenesis3BeFree
umls:C0596321Chemical Carcinogenesis3BeFree
umls:C0030354Papilloma2BeFree
umls:C0033860Psoriasis2BeFree
umls:C0037277Skin Diseases, Genetic2BeFree
umls:C0343111Naegeli syndrome2BeFree,CLINVAR,CTD_human,ORPHANET
umls:C0406778Dermatopathia pigmentosa reticularis2BeFree,CLINVAR,CTD_human,ORPHANET
umls:C0432315Epidermolysis bullosa simplex herpetiformis2BeFree
umls:C0870082Hyperkeratosis2BeFree
umls:C3539878Triple Negative Breast Neoplasms2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0004364Autoimmune Diseases1BeFree,LHGDN
umls:C0004779Basal Cell Nevus Syndrome1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0007621Neoplastic Cell Transformation1CTD_human
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0007873Uterine Cervical Neoplasm1BeFree
umls:C0013575Ectodermal Dysplasia1BeFree,LHGDN
umls:C0014859Esophageal Neoplasms1RGD
umls:C0019163Hepatitis B1BeFree
umls:C0019196Hepatitis C1BeFree
umls:C0024899Mastocytosis1BeFree
umls:C0027627Neoplasm Metastasis1RGD
umls:C0030436Parakeratosis1RGD
umls:C0032927Precancerous Conditions1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0036323Schistosomiasis1BeFree
umls:C0040411Tongue Neoplasms1CTD_human
umls:C0040997Trigeminal Neuralgia1BeFree
umls:C0042111Urticaria Pigmentosa1BeFree
umls:C0079153Hyperkeratosis, Epidermolytic1BeFree
umls:C0205874Papilloma, Squamous Cell1BeFree
umls:C0206708Cervical Intraepithelial Neoplasia1BeFree
umls:C0268375Autosomal dominant epidermolysis bullosa simplex1BeFree
umls:C0279671Cervical Squamous Cell Carcinoma1BeFree
umls:C0282612Prostatic Intraepithelial Neoplasias1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0333873Squamous intraepithelial lesion1BeFree
umls:C0343110Epidermolytic palmoplantar keratoderma of Vorner1BeFree
umls:C0406707Basan syndrome1BeFree
umls:C0549567Pigmentation Disorders1CTD_human
umls:C0699885Carcinoma of bladder1BeFree
umls:C0856825Acute GVH disease1BeFree
umls:C1270972Mild cognitive disorder1BeFree
umls:C1334274Invasive Carcinoma1BeFree
umls:C1449563Cardiomyopathy, Familial Idiopathic1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1510885Angiogenic Switch1BeFree
umls:C2145472Urothelial Carcinoma1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C3715082EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE 11MGD,ORPHANET,UNIPROT
umls:C0432316Epidermolysis bullosa simplex with mottled pigmentation0ORPHANET
umls:C1832926EPIDERMOLYSIS BULLOSA SIMPLEX, AUTOSOMAL RECESSIVE (disorder)0CLINVAR,CTD_human