TissGeneSummary for CEP85L |
Gene summary |
Basic gene information | Gene symbol | CEP85L |
Gene name | centrosomal protein 85kDa-like | |
Synonyms | C6orf204|NY-BR-15|bA57K17.2 | |
Cytomap | UCSC genome browser: 6q22 | |
Type of gene | protein-coding | |
RefGenes | NM_001042475.2, NM_001178035.1,NM_206921.2, | |
Description | centrosomal protein of 85 kDa-likeserologically defined breast cancer antigen NY-BR-15 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000111860 | ||
HPRD : 12874 | ||
Vega : OTTHUMG00000015465 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CEP85L | |
BioGPS: 387119 | ||
Pathway | NCI Pathway Interaction Database: CEP85L | |
KEGG: CEP85L | ||
REACTOME: CEP85L | ||
Pathway Commons: CEP85L | ||
Context | iHOP: CEP85L | |
ligand binding site mutation search in PubMed: CEP85L | ||
UCL Cancer Institute: CEP85L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CEP85L | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CEP85L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CEP85L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-15a-5p | MIMAT0000068 | 0.024 | -0.26 | 78 |
ACC | hsa-miR-15a-5p | MIMAT0000068 | 0.024 | -0.26 | 78 |
ACC | hsa-miR-4735-3p | MIMAT0019861 | 0.012 | -0.29 | 78 |
ACC | hsa-miR-4735-3p | MIMAT0019861 | 0.012 | -0.29 | 78 |
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TissGeneMut for CEP85L |
TissGeneSNV for CEP85L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S58C | LUAD | 1 |
p.Q808K | THYM | 1 |
p.G692D | STAD | 1 |
p.Q652E | BLCA | 1 |
p.N307H | UCEC | 1 |
p.V79M | ESCA | 1 |
p.K775Q | READ | 1 |
p.E764D | ESCA | 1 |
p.S765N | BLCA | 1 |
p.V105L | LIHC | 1 |
p.D169V | DLBC | 1 |
p.P98S | HNSC | 1 |
p.R707W | PRAD | 1 |
p.R347H | UCEC | 1 |
p.S293F | SKCM | 1 |
p.R704W | PRAD | 1 |
p.W156R | BLCA | 1 |
p.Q738R | PRAD | 1 |
p.Q569L | HNSC | 1 |
p.E472K | HNSC | 1 |
p.R739H | KIRP | 1 |
p.G67V | LUAD | 1 |
p.R507I | UCEC | 1 |
p.E761D | ESCA | 1 |
p.G369E | UCEC | 1 |
p.E375X | COAD | 1 |
p.A416V | PRAD | 1 |
p.R50Q | READ | 1 |
p.E452K | HNSC | 1 |
p.A42T | COAD | 1 |
p.R783X | COAD | 1 |
p.T309I | PAAD | 1 |
p.K663N | COAD | 1 |
p.M279T | LUAD | 1 |
p.E659K | LUSC | 1 |
p.S137G | COAD | 1 |
p.K574N | SARC | 1 |
p.G442R | HNSC | 1 |
p.Q527R | LUAD | 1 |
p.L647F | UCEC | 1 |
p.S745* | BLCA | 1 |
p.Q808E | CESC | 1 |
p.G187E | SKCM | 1 |
p.T10I | THYM | 1 |
p.I221V | LUSC | 1 |
p.T306I | PAAD | 1 |
p.N540T | PAAD | 1 |
p.E336Q | ESCA | 1 |
p.R704P | BLCA | 1 |
p.E785K | SARC | 1 |
p.V102L | LIHC | 1 |
p.K374R | BLCA | 1 |
p.L456V | COAD | 1 |
p.L644F | UCEC | 1 |
p.D713G | UCEC | 1 |
p.N612S | LUSC | 1 |
p.R350H | UCEC | 1 |
p.R4I | COAD | 1 |
p.Q735R | PRAD | 1 |
p.G344A | BLCA | 1 |
p.T96A | LUAD | 1 |
p.K551* | LUAD | 1 |
p.K505N | STAD | 1 |
p.Q383E | LUAD | 1 |
p.R398W | LIHC | 1 |
p.T99A | HNSC | 1 |
p.E454D | COAD | 1 |
p.M643V | DLBC | 1 |
p.Q535H | DLBC | 1 |
p.R50Q | UCEC | 1 |
p.P308S | SKCM | 1 |
p.E339Q | ESCA | 1 |
p.R380Q | UCEC | 1 |
p.Q170H | LUAD | 1 |
p.S131R | STAD | 1 |
p.T44A | LGG | 1 |
p.K542N | COAD | 1 |
p.R350H | ESCA | 1 |
p.G70S | STAD | 1 |
p.S348X | ESCA | 1 |
p.I186T | COAD | 1 |
p.S351L | HNSC | 1 |
p.Q688* | BLCA | 1 |
p.M130L | HNSC | 1 |
p.N543T | PAAD | 1 |
p.L672M | LUAD | 1 |
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TissGeneCNV for CEP85L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CEP85L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA091240 | CEP85L-EEF1A1 | chr6:118949774 | chr6:74228830 | |
Chimerdb3.0 | ChiTaRs | NA | AA329915 | CEP85L-DAB2IP | chr6:118953541 | chr9:124509859 | |
Chimerdb3.0 | ChiTaRs | NA | DB140993 | CEP85L-CUL1 | chr6:119031250 | chr7:148427054 | |
Chimerdb3.0 | ChiTaRs | NA | N86717 | GAS8-CEP85L | chr16:90102815 | chr6:118879994 | |
Chimerdb3.0 | FusionScan | LGG | TCGA-CS-6186-01A | CEP85L-SNX3 | 5'UTR-CDS | chr6:119031198 | chr6:108544249 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E9-A1RF-01A | OSTM1-CEP85L | Out-of-Frame | chr6:108395453 | chr6:118953774 |
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TissGeneNet for CEP85L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CEP85L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CEP85L |
TissGeneDrug for CEP85L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CEP85L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0014457 | Eosinophilia | 2 | BeFree |
umls:C0027022 | Myeloproliferative disease | 2 | BeFree |
umls:C1292778 | Chronic myeloproliferative disorder | 2 | BeFree |
umls:C1306759 | Eosinophilic disorder | 2 | BeFree |
umls:C1636667 | Disorder characterized by eosinophilia | 2 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | GAD |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0242596 | Neoplasm, Residual | 1 | BeFree |
umls:C0242698 | Ventricular Dysfunction, Left | 1 | GAD |
umls:C1292758 | Precursor T-cell lymphoblastic lymphoma | 1 | BeFree |