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| TissGeneSummary for CC2D2B |
 Gene summary |
| Basic gene information | Gene symbol | CC2D2B |
| Gene name | coiled-coil and C2 domain containing 2B | |
| Synonyms | C10orf130|bA248J23.4 | |
| Cytomap | UCSC genome browser: 10q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001001732.3, NM_001159747.1, | |
| Description | protein CC2D2B | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000188649 | ||
| HPRD : 16578 | ||
| Vega : OTTHUMG00000018820 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CC2D2B | |
| BioGPS: 387707 | ||
| Pathway | NCI Pathway Interaction Database: CC2D2B | |
| KEGG: CC2D2B | ||
| REACTOME: CC2D2B | ||
| Pathway Commons: CC2D2B | ||
| Context | iHOP: CC2D2B | |
| ligand binding site mutation search in PubMed: CC2D2B | ||
| UCL Cancer Institute: CC2D2B | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CC2D2B | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for CC2D2B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | -2.180744578 | -0.565334051 | -1.615410526 | 2.00E-07 | 9.88E-06 |
| LUSC | -2.408668933 | -0.754021874 | -1.654647059 | 1.13E-16 | 8.69E-16 |
| KICH | -1.928918893 | -0.821042893 | -1.107876 | 7.72E-06 | 2.49E-05 |
| THCA | 1.637895208 | -0.943316656 | 2.581211864 | 1.04E-17 | 2.33E-16 |
| Top |
| TissGene-miRNA for CC2D2B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CC2D2B |
| TissGeneSNV for CC2D2B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.H302R | COAD | 1 |
| p.R65Q | READ | 1 |
| p.G263R | SKCM | 1 |
| p.R293X | READ | 1 |
| p.E240V | COAD | 1 |
| p.E240K | SKCM | 1 |
| p.S75* | LUAD | 1 |
| p.P117H | PAAD | 1 |
| p.R21K | UCEC | 1 |
| p.Q226E | HNSC | 1 |
| p.G144R | UCEC | 1 |
| p.K81* | LUAD | 1 |
| p.K113N | BLCA | 1 |
| p.L108I | UCEC | 1 |
| p.S140N | SKCM | 1 |
| p.T262M | STAD | 1 |
| p.G26X | KIRC | 1 |
| p.I85M | BLCA | 1 |
| p.P291S | SKCM | 1 |
| p.I97T | BLCA | 1 |
| p.L189F | SARC | 1 |
| p.S130Y | LUAD | 1 |
| p.R302Q | UCEC | 1 |
| p.K22N | BLCA | 1 |
| p.K12* | UCEC | 1 |
| p.T229A | SKCM | 1 |
| p.E46K | SKCM | 1 |
| p.G253E | SKCM | 1 |
| p.I111V | HNSC | 1 |
| p.E326K | LIHC | 1 |
| p.F215L | HNSC | 1 |
| p.E373D | OV | 1 |
| p.S39Y | LUAD | 1 |
| p.L168* | LUAD | 1 |
| p.R293* | UCEC | 1 |
| p.R133* | ESCA | 1 |
| p.G144R | SKCM | 1 |
| p.T341M | STAD | 1 |
| p.K200E | SKCM | 1 |
| p.K86E | UCS | 1 |
| p.Y237H | DLBC | 1 |
| p.P248L | SKCM | 1 |
| p.K103R | HNSC | 1 |
| p.E187K | BLCA | 1 |
| p.I20V | HNSC | 1 |
| Top |
| TissGeneCNV for CC2D2B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for CC2D2B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CC2D2B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CC2D2B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CC2D2B |
| TissGeneDrug for CC2D2B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CC2D2B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
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