TissGeneSummary for FEZF1 |
Gene summary |
Basic gene information | Gene symbol | FEZF1 |
Gene name | FEZ family zinc finger 1 | |
Synonyms | FEZ|HH22|ZNF312B | |
Cytomap | UCSC genome browser: 7q31.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001024613.3, NM_001160264.2, | |
Description | fez family zinc finger protein 1zinc finger protein 312B | |
Modification date | 20141207 | |
dbXrefs | MIM : 613301 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128610 | ||
HPRD : 18614 | ||
Vega : OTTHUMG00000157091 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FEZF1 | |
BioGPS: 389549 | ||
Pathway | NCI Pathway Interaction Database: FEZF1 | |
KEGG: FEZF1 | ||
REACTOME: FEZF1 | ||
Pathway Commons: FEZF1 | ||
Context | iHOP: FEZF1 | |
ligand binding site mutation search in PubMed: FEZF1 | ||
UCL Cancer Institute: FEZF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FEZF1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FEZF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.491721766 | -3.129602535 | 2.637880769 | 1.50E-05 | 6.60E-05 |
LUSC | 0.364596711 | -2.384426818 | 2.749023529 | 7.90E-10 | 2.73E-09 |
LUAD | 0.258037651 | -2.475062349 | 2.7331 | 3.47E-12 | 2.57E-11 |
STAD | 1.157442177 | -2.700201573 | 3.85764375 | 1.63E-09 | 1.22E-07 |
BLCA | -1.184406179 | -2.668521968 | 1.484115789 | 0.00504 | 0.026614218 |
HNSC | -1.288505934 | -2.607638492 | 1.319132558 | 0.000813 | 0.002836047 |
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TissGene-miRNA for FEZF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-369-3p | MIMAT0000721 | 0.049 | -0.27 | 56 |
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TissGeneMut for FEZF1 |
TissGeneSNV for FEZF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N375S | READ | 1 |
p.A234V | READ | 1 |
p.P257L | SKCM | 1 |
p.G215A | HNSC | 1 |
p.T311M | PRAD | 1 |
p.T401A | STAD | 1 |
p.Q225P | HNSC | 1 |
p.G89R | SKCM | 1 |
p.G435A | LUSC | 1 |
p.P399L | SKCM | 1 |
p.S116R | KIRP | 1 |
p.L67H | LUAD | 1 |
p.C262F | HNSC | 1 |
p.I309F | MESO | 1 |
p.D396N | BLCA | 1 |
p.F325C | COAD | 1 |
p.S222C | BLCA | 1 |
p.P76S | SKCM | 1 |
p.A114T | SARC | 1 |
p.P172S | LUAD | 1 |
p.K62R | HNSC | 1 |
p.A430T | LUAD | 1 |
p.S329F | HNSC | 1 |
p.H191Q | OV | 1 |
p.G473D | LUSC | 1 |
p.A324S | BLCA | 1 |
p.E313K | SKCM | 1 |
p.P429S | UCEC | 1 |
p.Y229* | LUAD | 1 |
p.G20C | COAD | 1 |
p.E210Q | BLCA | 1 |
p.S64Y | LGG | 1 |
p.N164K | TGCT | 1 |
p.G59E | SKCM | 1 |
p.P457S | UCEC | 1 |
p.D247E | SKCM | 1 |
p.M279K | BLCA | 1 |
p.H306N | SARC | 1 |
p.D424N | BLCA | 1 |
p.R250* | LUSC | 1 |
p.N395K | HNSC | 1 |
p.D414N | BLCA | 1 |
p.G251D | HNSC | 1 |
p.A271V | PRAD | 1 |
p.Q225H | OV | 1 |
p.E239K | SKCM | 1 |
p.P403L | HNSC | 1 |
p.T432K | LUAD | 1 |
p.V216L | SARC | 1 |
p.P79H | STAD | 1 |
p.S328I | ACC | 1 |
p.R96Q | STAD | 1 |
p.I71V | PAAD | 1 |
p.C410X | ESCA | 1 |
p.A156D | UCEC | 1 |
p.G54E | SKCM | 1 |
p.E232K | SKCM | 1 |
p.P76L | SKCM | 1 |
p.R420C | SKCM | 1 |
p.R286K | GBM | 1 |
p.A208V | HNSC | 1 |
p.E210D | THYM | 1 |
p.A108E | LUSC | 1 |
p.R96Q | HNSC | 1 |
p.K87R | PAAD | 1 |
p.G296S | SKCM | 1 |
p.P49S | SKCM | 1 |
p.P441Q | LUAD | 1 |
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TissGeneCNV for FEZF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FEZF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FEZF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FEZF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FEZF1 |
TissGeneDrug for FEZF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FEZF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0004352 | Autistic Disorder | 1 | GAD |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0162809 | Kallmann Syndrome | 1 | BeFree,ORPHANET |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C4014988 | HYPOGONADOTROPIC HYPOGONADISM 22 WITH OR WITHOUT ANOSMIA | 1 | UNIPROT |