TissGeneSummary for OR4M2 |
Gene summary |
Basic gene information | Gene symbol | OR4M2 |
Gene name | olfactory receptor, family 4, subfamily M, member 2 | |
Synonyms | OR15-3 | |
Cytomap | UCSC genome browser: 15q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001004719.2, | |
Description | olfactory receptor 4M2olfactory receptor OR15-3 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000274102 | ||
HPRD : 14984 | ||
Vega : OTTHUMG00000171738 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OR4M2 | |
BioGPS: 390538 | ||
Pathway | NCI Pathway Interaction Database: OR4M2 | |
KEGG: OR4M2 | ||
REACTOME: OR4M2 | ||
Pathway Commons: OR4M2 | ||
Context | iHOP: OR4M2 | |
ligand binding site mutation search in PubMed: OR4M2 | ||
UCL Cancer Institute: OR4M2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OR4M2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OR4M2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for OR4M2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OR4M2 |
TissGeneSNV for OR4M2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S268F | SKCM | 11 |
p.P282S | SKCM | 3 |
p.E111K | SKCM | 2 |
p.G151E | SKCM | 2 |
p.S33F | SKCM | 2 |
p.L44F | SKCM | 2 |
p.G41E | SKCM | 2 |
p.E11* | UCEC | 2 |
p.R165* | SKCM | 2 |
p.R165Q | UCEC | 2 |
p.P167S | SKCM | 2 |
p.C142G | COAD | 1 |
p.L269I | LUAD | 1 |
p.G230C | LUAD | 1 |
p.S266W | LUAD | 1 |
p.I98F | LUAD | 1 |
p.V184F | LUAD | 1 |
p.E196D | STAD | 1 |
p.P58S | STAD | 1 |
p.L51I | LUAD | 1 |
p.Y243H | ACC | 1 |
p.S244F | SKCM | 1 |
p.M1I | ACC | 1 |
p.T15N | LGG | 1 |
p.R165* | UCEC | 1 |
p.E11G | STAD | 1 |
p.S266R | LUAD | 1 |
p.A238V | COAD | 1 |
p.C141Y | THYM | 1 |
p.L221F | SKCM | 1 |
p.S244A | HNSC | 1 |
p.I38T | COAD | 1 |
p.Q24H | ESCA | 1 |
p.F85L | LUAD | 1 |
p.P40L | HNSC | 1 |
p.A119S | LUAD | 1 |
p.R150M | HNSC | 1 |
p.E195D | UCEC | 1 |
p.R284H | COAD | 1 |
p.A219D | LUSC | 1 |
p.R165Q | STAD | 1 |
p.Y177H | LUSC | 1 |
p.S266T | LUAD | 1 |
p.G204V | LUAD | 1 |
p.Y35C | LUSC | 1 |
p.F61Y | STAD | 1 |
p.Q159X | STAD | 1 |
p.V9L | LUAD | 1 |
p.V272L | STAD | 1 |
p.K90R | LUAD | 1 |
p.L115F | LUAD | 1 |
p.D52N | SKCM | 1 |
p.G16C | HNSC | 1 |
p.C97S | STAD | 1 |
p.G152C | LUAD | 1 |
p.R262G | HNSC | 1 |
p.G152D | SKCM | 1 |
p.L279I | LUAD | 1 |
p.N285K | SKCM | 1 |
p.E312K | SKCM | 1 |
p.G16V | LUAD | 1 |
p.T77S | LUAD | 1 |
p.A119V | SKCM | 1 |
p.V13A | ACC | 1 |
p.R150M | LUSC | 1 |
p.K297Q | SKCM | 1 |
p.F113L | LUAD | 1 |
p.C242S | LIHC | 1 |
p.F102Y | SKCM | 1 |
p.A161S | LUAD | 1 |
p.G204C | LUAD | 1 |
p.A4T | STAD | 1 |
p.N5T | LUSC | 1 |
p.R237M | BLCA | 1 |
p.Q159* | STAD | 1 |
p.S207F | SKCM | 1 |
p.P171S | UCEC | 1 |
p.A223D | LUAD | 1 |
p.T182S | LIHC | 1 |
p.L104V | STAD | 1 |
p.K313N | LUAD | 1 |
p.L104V | ESCA | 1 |
p.A64V | SKCM | 1 |
p.E111K | SARC | 1 |
p.E2K | SKCM | 1 |
p.V87L | LUSC | 1 |
p.A238P | SKCM | 1 |
p.E233* | KIRC | 1 |
p.L25R | STAD | 1 |
p.P40T | BLCA | 1 |
p.G41R | BLCA | 1 |
p.R237S | HNSC | 1 |
p.D121Y | UCEC | 1 |
p.L62P | SKCM | 1 |
p.P40S | UCEC | 1 |
p.P286S | SKCM | 1 |
p.C97Y | UCEC | 1 |
p.V272L | SKCM | 1 |
p.I126F | LUAD | 1 |
p.P194S | SKCM | 1 |
p.P282H | LUSC | 1 |
p.E88D | SKCM | 1 |
p.Q100L | LUSC | 1 |
p.F276L | SKCM | 1 |
p.A213V | LUSC | 1 |
p.D84Y | UCEC | 1 |
p.R262L | LUSC | 1 |
p.M136I | SKCM | 1 |
p.F68L | HNSC | 1 |
p.L14V | LUSC | 1 |
p.V117L | LUAD | 1 |
p.A223T | SKCM | 1 |
p.R150M | LUAD | 1 |
p.C179G | LUSC | 1 |
p.F153L | UCEC | 1 |
p.R165X | SKCM | 1 |
p.Q159R | LUAD | 1 |
p.E196K | SKCM | 1 |
p.P263S | BLCA | 1 |
p.K90N | LIHC | 1 |
p.G151R | SKCM | 1 |
p.L62M | OV | 1 |
p.G41V | UCEC | 1 |
p.K311* | LUSC | 1 |
p.D84N | SKCM | 1 |
p.P282S | OV | 1 |
p.E295K | SKCM | 1 |
p.T134I | HNSC | 1 |
p.R139P | SKCM | 1 |
p.C179F | LUSC | 1 |
p.E233X | KIRC | 1 |
p.S256F | SKCM | 1 |
p.S231A | COAD | 1 |
p.A109T | SKCM | 1 |
p.V273M | COAD | 1 |
p.R89K | SKCM | 1 |
p.F153L | BLCA | 1 |
p.W149* | SKCM | 1 |
p.G152A | HNSC | 1 |
p.A238V | STAD | 1 |
p.P263T | PRAD | 1 |
p.H54Y | LUAD | 1 |
p.P21S | SKCM | 1 |
p.R150W | LUSC | 1 |
p.S240Y | SKCM | 1 |
p.D70Y | LUAD | 1 |
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TissGeneCNV for OR4M2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OR4M2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OR4M2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OR4M2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OR4M2 |
TissGeneDrug for OR4M2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OR4M2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |