TissGeneSummary for C10orf120 |
Gene summary |
Basic gene information | Gene symbol | C10orf120 |
Gene name | chromosome 10 open reading frame 120 | |
Synonyms | bA318C4.1 | |
Cytomap | UCSC genome browser: 10q26.13 | |
Type of gene | protein-coding | |
RefGenes | NM_001010912.2, | |
Description | uncharacterized protein C10orf120 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000183559 | ||
HPRD : 16577 | ||
Vega : OTTHUMG00000019187 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C10orf120 | |
BioGPS: 399814 | ||
Pathway | NCI Pathway Interaction Database: C10orf120 | |
KEGG: C10orf120 | ||
REACTOME: C10orf120 | ||
Pathway Commons: C10orf120 | ||
Context | iHOP: C10orf120 | |
ligand binding site mutation search in PubMed: C10orf120 | ||
UCL Cancer Institute: C10orf120 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C10orf120 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C10orf120 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C10orf120 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C10orf120 |
TissGeneSNV for C10orf120 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S39F | SKCM | 3 |
p.S303L | SKCM | 2 |
p.H180Y | SKCM | 2 |
p.S265L | SKCM | 2 |
p.R263C | SKCM | 2 |
p.E232Q | BLCA | 1 |
p.A94G | LUAD | 1 |
p.S130F | SKCM | 1 |
p.E187A | KICH | 1 |
p.S67L | SKCM | 1 |
p.S193L | SKCM | 1 |
p.P30S | READ | 1 |
p.G87D | SKCM | 1 |
p.Q181H | STAD | 1 |
p.E124Q | BLCA | 1 |
p.D221V | PAAD | 1 |
p.I142K | LUAD | 1 |
p.G178R | HNSC | 1 |
p.P132S | COAD | 1 |
p.H129R | SKCM | 1 |
p.D222N | SKCM | 1 |
p.R282Q | SARC | 1 |
p.P291S | COAD | 1 |
p.D300Y | COAD | 1 |
p.P78S | LUAD | 1 |
p.R274W | STAD | 1 |
p.E187K | SKCM | 1 |
p.L267F | SKCM | 1 |
p.D222V | LUSC | 1 |
p.R210Q | SKCM | 1 |
p.P157L | SKCM | 1 |
p.E28* | LUAD | 1 |
p.H167Y | UCEC | 1 |
p.G260E | SKCM | 1 |
p.K166R | COAD | 1 |
p.P268H | LUAD | 1 |
p.E28K | SKCM | 1 |
p.R238* | OV | 1 |
p.A149V | UCEC | 1 |
p.K29R | CESC | 1 |
p.D300N | SKCM | 1 |
p.R107T | ACC | 1 |
p.F247L | UCEC | 1 |
p.G178V | LUAD | 1 |
p.E80Q | BLCA | 1 |
p.R175W | SKCM | 1 |
p.P117L | SKCM | 1 |
p.R66K | ACC | 1 |
p.A330P | LAML | 1 |
p.F40C | SKCM | 1 |
p.S18G | BRCA | 1 |
p.H334Y | SKCM | 1 |
p.A204E | LUAD | 1 |
p.E187* | KICH | 1 |
p.P332S | SKCM | 1 |
p.D19G | UCEC | 1 |
p.R326L | LUSC | 1 |
p.M297I | SKCM | 1 |
p.R238T | LUAD | 1 |
p.G233E | SKCM | 1 |
p.M171I | LUAD | 1 |
p.L98S | SKCM | 1 |
p.R304Q | COAD | 1 |
p.K329E | SKCM | 1 |
p.R191S | LUAD | 1 |
p.I33V | HNSC | 1 |
p.P182S | UCEC | 1 |
p.A17T | SKCM | 1 |
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TissGeneCNV for C10orf120 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C10orf120 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-GI-A2C8-01A | NT5C2-C10orf120 | In-frame | Chr10:104934615 | Chr10:124458928 |
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TissGeneNet for C10orf120 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C10orf120 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C10orf120 |
TissGeneDrug for C10orf120 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C10orf120 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |