TissGeneSummary for CCSER1 |
Gene summary |
Basic gene information | Gene symbol | CCSER1 |
Gene name | coiled-coil serine-rich protein 1 | |
Synonyms | FAM190A | |
Cytomap | UCSC genome browser: 4q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001145065.1, NM_207491.2, | |
Description | family with sequence similarity 190, member Aprotein FAM190Aserine-rich coiled-coil domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000184305 | ||
HPRD : 17561 | ||
Vega : OTTHUMG00000160950 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCSER1 | |
BioGPS: 401145 | ||
Pathway | NCI Pathway Interaction Database: CCSER1 | |
KEGG: CCSER1 | ||
REACTOME: CCSER1 | ||
Pathway Commons: CCSER1 | ||
Context | iHOP: CCSER1 | |
ligand binding site mutation search in PubMed: CCSER1 | ||
UCL Cancer Institute: CCSER1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCSER1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCSER1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCSER1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCSER1 |
TissGeneSNV for CCSER1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q587X | SKCM | 2 |
p.Q587* | SKCM | 2 |
p.E676K | SKCM | 2 |
p.V117F | PRAD | 1 |
p.A603E | LUAD | 1 |
p.A549S | ACC | 1 |
p.V545F | SARC | 1 |
p.T582S | LUAD | 1 |
p.R461L | CHOL | 1 |
p.R640G | LIHC | 1 |
p.R640I | LUAD | 1 |
p.Q255E | BLCA | 1 |
p.E528K | SKCM | 1 |
p.V544I | HNSC | 1 |
p.M561I | SKCM | 1 |
p.R64L | ESCA | 1 |
p.A404T | LUAD | 1 |
p.A548T | LUAD | 1 |
p.D479Y | BLCA | 1 |
p.S334C | LUAD | 1 |
p.L29I | THYM | 1 |
p.R489G | ESCA | 1 |
p.E140G | LIHC | 1 |
p.H188Y | SKCM | 1 |
p.R237L | BLCA | 1 |
p.V747E | LIHC | 1 |
p.E664V | LIHC | 1 |
p.A404S | ESCA | 1 |
p.I419L | BLCA | 1 |
p.S275Y | STAD | 1 |
p.S578F | SKCM | 1 |
p.P46S | SKCM | 1 |
p.S120N | STAD | 1 |
p.A369S | PAAD | 1 |
p.D515N | KIRP | 1 |
p.S645R | SKCM | 1 |
p.R537L | SKCM | 1 |
p.R59Q | SKCM | 1 |
p.R219G | HNSC | 1 |
p.S32L | HNSC | 1 |
p.M100L | PRAD | 1 |
p.D415H | HNSC | 1 |
p.R537Q | LUAD | 1 |
p.T431A | LGG | 1 |
p.H425Y | LUAD | 1 |
p.L355Q | LUAD | 1 |
p.R64H | LGG | 1 |
p.S770L | DLBC | 1 |
p.E138K | SKCM | 1 |
p.H72Q | HNSC | 1 |
p.A262D | LUAD | 1 |
p.E571K | LIHC | 1 |
p.S45F | LUAD | 1 |
p.P601L | SKCM | 1 |
p.E665K | SKCM | 1 |
p.K417N | LUAD | 1 |
p.G737R | SARC | 1 |
p.D515A | KIRP | 1 |
p.R64C | SKCM | 1 |
p.R225K | SKCM | 1 |
p.R137K | SKCM | 1 |
p.R392K | DLBC | 1 |
p.E140* | LUAD | 1 |
p.D250G | LUAD | 1 |
p.T894S | ESCA | 1 |
p.L821V | ESCA | 1 |
p.M558I | SKCM | 1 |
p.G900R | SARC | 1 |
p.P321L | SKCM | 1 |
p.L642F | SKCM | 1 |
p.G434A | LUAD | 1 |
p.A342V | LIHC | 1 |
p.S240R | STAD | 1 |
p.D266N | SKCM | 1 |
p.D515G | LGG | 1 |
p.A549T | STAD | 1 |
p.E611K | SKCM | 1 |
p.M280I | SKCM | 1 |
p.P567S | ESCA | 1 |
p.P46S | LUAD | 1 |
p.R675S | ESCA | 1 |
p.R237W | STAD | 1 |
p.R123Q | SKCM | 1 |
p.D160G | PCPG | 1 |
p.E665* | LUAD | 1 |
p.P420S | SKCM | 1 |
p.K193M | LUAD | 1 |
p.A301S | LUAD | 1 |
p.S69T | SKCM | 1 |
p.Q849H | ESCA | 1 |
p.S200F | SKCM | 1 |
p.K879M | SARC | 1 |
p.R743X | DLBC | 1 |
p.R170H | LUAD | 1 |
p.A549T | BLCA | 1 |
p.C230F | STAD | 1 |
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TissGeneCNV for CCSER1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCSER1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CX779624 | CCSER1-C5orf34 | chr4:92473923 | chr5:43506993 |
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TissGeneNet for CCSER1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCSER1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCSER1 |
TissGeneDrug for CCSER1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCSER1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001925 | Albuminuria | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |