TissGeneSummary for FAM166A |
Gene summary |
Basic gene information | Gene symbol | FAM166A |
Gene name | family with sequence similarity 166, member A | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q34.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001001710.2, | |
Description | protein FAM166A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000188163 | ||
HPRD : 13441 | ||
Vega : OTTHUMG00000159545 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM166A | |
BioGPS: 401565 | ||
Pathway | NCI Pathway Interaction Database: FAM166A | |
KEGG: FAM166A | ||
REACTOME: FAM166A | ||
Pathway Commons: FAM166A | ||
Context | iHOP: FAM166A | |
ligand binding site mutation search in PubMed: FAM166A | ||
UCL Cancer Institute: FAM166A | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM166A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM166A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM166A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM166A |
TissGeneSNV for FAM166A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P184S | STAD | 1 |
p.L150F | BLCA | 1 |
p.Y294* | SKCM | 1 |
p.M239V | STAD | 1 |
p.Q179H | BLCA | 1 |
p.G221S | LUAD | 1 |
p.P153T | STAD | 1 |
p.V48A | HNSC | 1 |
p.D243H | BLCA | 1 |
p.P135L | STAD | 1 |
p.F245L | BLCA | 1 |
p.R171K | LUAD | 1 |
p.R253K | LUAD | 1 |
p.P106S | KIRC | 1 |
p.D146N | HNSC | 1 |
p.H173Q | KIRC | 1 |
p.W307C | CESC | 1 |
p.Q200* | BLCA | 1 |
p.G36E | ESCA | 1 |
p.P153R | BLCA | 1 |
p.P255H | COAD | 1 |
p.G22D | PRAD | 1 |
p.I211F | STAD | 1 |
p.H177Y | SKCM | 1 |
p.C178Y | UCEC | 1 |
p.A187P | PCPG | 1 |
p.Y85N | STAD | 1 |
p.R37H | STAD | 1 |
p.P132L | HNSC | 1 |
p.A21T | STAD | 1 |
p.L104F | LUSC | 1 |
p.L126M | PAAD | 1 |
p.G156E | SKCM | 1 |
p.P84L | LAML | 1 |
p.L175_splice | LUSC | 1 |
p.E244K | SKCM | 1 |
p.M290K | OV | 1 |
p.P94L | SKCM | 1 |
p.P269T | PAAD | 1 |
p.M239L | STAD | 1 |
p.E192K | SKCM | 1 |
p.D181N | SKCM | 1 |
p.V17I | BRCA | 1 |
p.T302A | LUAD | 1 |
p.R201Q | UCEC | 1 |
p.F282L | BRCA | 1 |
p.E113Q | BLCA | 1 |
p.S60T | COAD | 1 |
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TissGeneCNV for FAM166A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM166A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM166A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM166A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM166A |
TissGeneDrug for FAM166A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM166A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |