TissGeneSummary for MAGEB1 |
Gene summary |
Basic gene information | Gene symbol | MAGEB1 |
Gene name | melanoma antigen family B, 1 | |
Synonyms | CT3.1|DAM10|MAGE-Xp|MAGEL1 | |
Cytomap | UCSC genome browser: Xp21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_002363.4, NM_177404.2,NM_177415.2, | |
Description | DSS-AHC critical interval MAGE superfamily 10DSS/AHC critical interval MAGE superfamily 10MAGE-B1 antigenMAGE-XP antigencancer/testis antigen 3.1cancer/testis antigen family 3, member 1melanoma-associated antigen B1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300097 | |
HGNC : HGNC | ||
Ensembl : ENSG00000214107 | ||
HPRD : 02108 | ||
Vega : OTTHUMG00000021322 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAGEB1 | |
BioGPS: 4112 | ||
Pathway | NCI Pathway Interaction Database: MAGEB1 | |
KEGG: MAGEB1 | ||
REACTOME: MAGEB1 | ||
Pathway Commons: MAGEB1 | ||
Context | iHOP: MAGEB1 | |
ligand binding site mutation search in PubMed: MAGEB1 | ||
UCL Cancer Institute: MAGEB1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTExHPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
Reference showing the relevant tissue of MAGEB1 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MAGEB1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.035849067 | -2.119671067 | 1.083822 | 0.000718 | 0.002023703 |
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TissGene-miRNA for MAGEB1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MAGEB1 |
TissGeneSNV for MAGEB1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E287K | SKCM | 2 |
p.E81K | SKCM | 2 |
p.S102I | LUAD | 1 |
p.S336C | BLCA | 1 |
p.A18V | CESC | 1 |
p.P274S | SKCM | 1 |
p.E21D | CESC | 1 |
p.P53T | HNSC | 1 |
p.F118V | COAD | 1 |
p.I208V | STAD | 1 |
p.R267C | STAD | 1 |
p.Y230F | SKCM | 1 |
p.E252K | SKCM | 1 |
p.E78* | HNSC | 1 |
p.W110C | LUAD | 1 |
p.E287Q | BLCA | 1 |
p.W110R | STAD | 1 |
p.T22S | PCPG | 1 |
p.F270L | HNSC | 1 |
p.V104F | BLCA | 1 |
p.R325C | COAD | 1 |
p.K291R | ESCA | 1 |
p.R335C | SARC | 1 |
p.P170L | SKCM | 1 |
p.E279K | BRCA | 1 |
p.T330M | PAAD | 1 |
p.R325C | LGG | 1 |
p.A276P | LUAD | 1 |
p.E78K | UCEC | 1 |
p.E167D | STAD | 1 |
p.E36* | UCEC | 1 |
p.K243N | CESC | 1 |
p.D144N | HNSC | 1 |
p.D144G | UCEC | 1 |
p.L165V | STAD | 1 |
p.R325S | HNSC | 1 |
p.R335H | GBM | 1 |
p.S319T | LUSC | 1 |
p.T331N | SKCM | 1 |
p.E217K | SKCM | 1 |
p.L286P | LUAD | 1 |
p.I208T | GBM | 1 |
p.R242H | COAD | 1 |
p.T98A | COAD | 1 |
p.Y268C | BLCA | 1 |
p.L286P | LIHC | 1 |
p.H345N | LUSC | 1 |
p.F161L | LUSC | 1 |
p.A215V | SKCM | 1 |
p.E167K | SKCM | 1 |
p.R318* | STAD | 1 |
p.W193L | LUAD | 1 |
p.Y257* | HNSC | 1 |
p.E101* | LUAD | 1 |
p.F146Y | OV | 1 |
p.V226G | LUAD | 1 |
p.E234D | GBM | 1 |
p.R275K | UCEC | 1 |
p.G187E | SKCM | 1 |
p.L205Q | LUAD | 1 |
p.R314G | LUAD | 1 |
p.R3W | LUSC | 1 |
p.P265H | LUAD | 1 |
p.M224I | HNSC | 1 |
p.R15C | UCEC | 1 |
p.R325C | STAD | 1 |
p.P61S | UCEC | 1 |
p.A28S | UCS | 1 |
p.G239W | LUAD | 1 |
p.R10H | GBM | 1 |
p.H235Q | BRCA | 1 |
p.A30D | COAD | 1 |
p.Q95H | LUAD | 1 |
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TissGeneCNV for MAGEB1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MAGEB1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MAGEB1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MAGEB1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MAGEB1 |
TissGeneDrug for MAGEB1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MAGEB1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 1 | LHGDN |
umls:C0220766 | Congenital hypoplasia of adrenal gland | 1 | BeFree |