TissGeneSummary for ARSE |
Gene summary |
Basic gene information | Gene symbol | ARSE |
Gene name | arylsulfatase E (chondrodysplasia punctata 1) | |
Synonyms | ASE|CDPX|CDPX1|CDPXR | |
Cytomap | UCSC genome browser: Xp22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_000047.2, NM_001282628.1,NM_001282631.1, | |
Description | arylsulfatase E | |
Modification date | 20141219 | |
dbXrefs | MIM : 300180 | |
HGNC : HGNC | ||
Ensembl : ENSG00000157399 | ||
HPRD : 02171 | ||
Vega : OTTHUMG00000137358 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARSE | |
BioGPS: 415 | ||
Pathway | NCI Pathway Interaction Database: ARSE | |
KEGG: ARSE | ||
REACTOME: ARSE | ||
Pathway Commons: ARSE | ||
Context | iHOP: ARSE | |
ligand binding site mutation search in PubMed: ARSE | ||
UCL Cancer Institute: ARSE | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPAAD | |
Reference showing the relevant tissue of ARSE | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ARSE |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -3.34201809 | -4.579697751 | 1.237679661 | 5.62E-08 | 2.53E-07 |
KIRC | 4.596080827 | 3.403646105 | 1.192434722 | 4.05E-10 | 1.36E-09 |
LUSC | -1.418369336 | 0.440448311 | -1.858817647 | 4.68E-08 | 1.36E-07 |
HNSC | -2.026781511 | -3.061504767 | 1.034723256 | 0.000407 | 0.001554754 |
STAD | 1.902127355 | -0.276960145 | 2.1790875 | 0.000114 | 0.000866169 |
LUAD | 1.922371536 | 0.784028433 | 1.138343103 | 7.22E-05 | 0.000186787 |
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TissGene-miRNA for ARSE |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ARSE |
TissGeneSNV for ARSE |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A164S | LUAD | 1 |
p.V558A | SARC | 1 |
p.H6R | STAD | 1 |
p.D413N | STAD | 1 |
p.L40P | PRAD | 1 |
p.D72N | STAD | 1 |
p.R215C | LGG | 1 |
p.L236I | STAD | 1 |
p.R190C | LGG | 1 |
p.L238F | STAD | 1 |
p.A155V | UCEC | 1 |
p.P499S | BRCA | 1 |
p.Q460R | LGG | 1 |
p.S201F | LUSC | 1 |
p.S352L | PAAD | 1 |
p.L15P | PRAD | 1 |
p.T60A | LIHC | 1 |
p.D352N | LUSC | 1 |
p.R403Q | COAD | 1 |
p.S352L | UCS | 1 |
p.S7F | HNSC | 1 |
p.S106F | HNSC | 1 |
p.Q264X | KIRP | 1 |
p.A514T | SKCM | 1 |
p.S16F | HNSC | 1 |
p.V300I | COAD | 1 |
p.A205D | UCEC | 1 |
p.R282K | SKCM | 1 |
p.V112A | READ | 1 |
p.H189Y | SKCM | 1 |
p.A305V | GBM | 1 |
p.S377L | UCS | 1 |
p.L436V | LUAD | 1 |
p.E325* | UCEC | 1 |
p.P251S | PRAD | 1 |
p.T287S | LUAD | 1 |
p.G355S | KIRP | 1 |
p.C86Y | UCEC | 1 |
p.S201F | SKCM | 1 |
p.T287M | GBM | 1 |
p.D8N | CESC | 1 |
p.G397R | BLCA | 1 |
p.P593S | SKCM | 1 |
p.C498G | SKCM | 1 |
p.L372H | SKCM | 1 |
p.P27S | UCEC | 1 |
p.V247I | LGG | 1 |
p.A305E | LUAD | 1 |
p.C177S | GBM | 1 |
p.H164Y | SKCM | 1 |
p.G142R | BLCA | 1 |
p.W370S | BRCA | 1 |
p.S30F | UCEC | 1 |
p.A544V | UCEC | 1 |
p.C523G | SKCM | 1 |
p.P246L | SKCM | 1 |
p.D57N | SKCM | 1 |
p.R257K | SKCM | 1 |
p.V426A | UCEC | 1 |
p.L283F | UCEC | 1 |
p.G380S | KIRP | 1 |
p.D32N | SKCM | 1 |
p.D92N | LUAD | 1 |
p.L308F | UCEC | 1 |
p.S377L | PAAD | 1 |
p.L347P | LIHC | 1 |
p.A488T | HNSC | 1 |
p.G57V | UCEC | 1 |
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TissGeneCNV for ARSE |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ARSE |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ARSE |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ARSE |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ARSE |
TissGeneDrug for ARSE |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ARSE |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0008445 | Chondrodysplasia Punctata | 15 | BeFree |
umls:C1844853 | Brachytelephalangic Chondrodysplasia Punctata | 6 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C3669395 | X-Linked Chondrodysplasia Punctata 1 | 3 | BeFree |
umls:C0041408 | Turner Syndrome | 2 | BeFree |
umls:C0013336 | Dwarfism | 1 | BeFree |
umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0855197 | Testicular malignant germ cell tumor | 1 | BeFree |