TissGeneSummary for ARSF |
Gene summary |
Basic gene information | Gene symbol | ARSF |
Gene name | arylsulfatase F | |
Synonyms | ASF | |
Cytomap | UCSC genome browser: Xp22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001201538.1, NM_001201539.1,NM_004042.4, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | MIM : 300003 | |
HGNC : HGNC | ||
Ensembl : ENSG00000062096 | ||
HPRD : 02049 | ||
Vega : OTTHUMG00000021081 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARSF | |
BioGPS: 416 | ||
Pathway | NCI Pathway Interaction Database: ARSF | |
KEGG: ARSF | ||
REACTOME: ARSF | ||
Pathway Commons: ARSF | ||
Context | iHOP: ARSF | |
ligand binding site mutation search in PubMed: ARSF | ||
UCL Cancer Institute: ARSF | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneySkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSKCM | |
Reference showing the relevant tissue of ARSF | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ARSF |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | -2.292030781 | -0.699878858 | -1.592151923 | 3.78E-14 | 3.39E-12 |
HNSC | -1.786216157 | 2.483560587 | -4.269776744 | 1.02E-17 | 3.26E-15 |
KIRP | -0.33662357 | 3.21082643 | -3.54745 | 3.59E-07 | 1.99E-06 |
LIHC | 0.15492668 | 2.70986268 | -2.554936 | 4.00E-06 | 1.87E-05 |
KICH | -2.90111132 | 1.74185668 | -4.642968 | 1.89E-09 | 1.13E-08 |
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TissGene-miRNA for ARSF |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ARSF |
TissGeneSNV for ARSF |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E281K | SKCM | 2 |
p.E588K | SKCM | 2 |
p.H471Y | SKCM | 1 |
p.V381I | LAML | 1 |
p.R262X | COAD | 1 |
p.A393T | SKCM | 1 |
p.D301N | UCEC | 1 |
p.G264V | PAAD | 1 |
p.V498I | UCEC | 1 |
p.Q21K | PRAD | 1 |
p.G347* | LUAD | 1 |
p.G136C | SKCM | 1 |
p.K390N | DLBC | 1 |
p.C449F | LUAD | 1 |
p.S288F | SKCM | 1 |
p.G383E | SKCM | 1 |
p.G415E | LUSC | 1 |
p.V170L | LUAD | 1 |
p.T238K | LUAD | 1 |
p.E252K | SKCM | 1 |
p.E577K | SKCM | 1 |
p.R147X | STAD | 1 |
p.S466L | HNSC | 1 |
p.Q542H | UCEC | 1 |
p.C151* | LUAD | 1 |
p.A197V | UCEC | 1 |
p.E496K | SKCM | 1 |
p.R179C | SKCM | 1 |
p.G374A | COAD | 1 |
p.G394R | SKCM | 1 |
p.N314H | OV | 1 |
p.G347R | SKCM | 1 |
p.S236I | LUAD | 1 |
p.V170D | SKCM | 1 |
p.G164S | BLCA | 1 |
p.G364R | SKCM | 1 |
p.R4S | LUAD | 1 |
p.G210S | STAD | 1 |
p.V534M | SKCM | 1 |
p.R249P | LUAD | 1 |
p.A393S | SARC | 1 |
p.G378R | SKCM | 1 |
p.M321I | SKCM | 1 |
p.L169V | BLCA | 1 |
p.Q106* | HNSC | 1 |
p.G389R | SKCM | 1 |
p.D463N | SKCM | 1 |
p.S516F | SKCM | 1 |
p.G567E | SKCM | 1 |
p.E186G | PRAD | 1 |
p.L203Q | LUAD | 1 |
p.R395W | LGG | 1 |
p.P460S | SKCM | 1 |
p.L290I | COAD | 1 |
p.R457W | KIRC | 1 |
p.H501N | LUAD | 1 |
p.L228H | THCA | 1 |
p.M258I | SKCM | 1 |
p.Q358K | LUAD | 1 |
p.R386* | STAD | 1 |
p.Q70P | GBM | 1 |
p.A328T | BRCA | 1 |
p.M36I | LUAD | 1 |
p.V476I | SKCM | 1 |
p.S581F | CESC | 1 |
p.R102K | CHOL | 1 |
p.Y48H | DLBC | 1 |
p.R147* | STAD | 1 |
p.G495R | SKCM | 1 |
p.S209R | LUAD | 1 |
p.V322M | SKCM | 1 |
p.I42F | KIRC | 1 |
p.E186D | HNSC | 1 |
p.L169V | CESC | 1 |
p.D405N | SKCM | 1 |
p.E64K | SKCM | 1 |
p.E443* | UCEC | 1 |
p.D528N | SKCM | 1 |
p.A263V | SKCM | 1 |
p.E255* | LUSC | 1 |
p.H527Y | COAD | 1 |
p.V381I | GBM | 1 |
p.G369R | DLBC | 1 |
p.R559S | ESCA | 1 |
p.G133R | UCEC | 1 |
p.D330N | READ | 1 |
p.T499N | OV | 1 |
p.A22T | COAD | 1 |
p.Q542K | STAD | 1 |
p.R249L | LUAD | 1 |
p.S213C | BLCA | 1 |
p.R386X | STAD | 1 |
p.P382S | LUSC | 1 |
p.R584W | UCEC | 1 |
p.G364E | SKCM | 1 |
p.C173F | PRAD | 1 |
p.R386* | HNSC | 1 |
p.D301N | SKCM | 1 |
p.G46R | COAD | 1 |
p.G347E | SKCM | 1 |
p.V104A | UCEC | 1 |
p.R179H | HNSC | 1 |
p.R103C | STAD | 1 |
p.G389E | SKCM | 1 |
p.W233* | SKCM | 1 |
p.A411T | SKCM | 1 |
p.G164D | PRAD | 1 |
p.H278Q | LUAD | 1 |
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TissGeneCNV for ARSF |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ARSF |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ARSF |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ARSF |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ARSF |
TissGeneDrug for ARSF |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ARSF |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
umls:C0021400 | Influenza | 1 | BeFree |
umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
umls:C0027121 | Myositis | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0030354 | Papilloma | 1 | BeFree |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0270814 | Spastic syndrome | 1 | BeFree |
umls:C0339510 | Vitelliform Macular Dystrophy | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1860406 | VITREORETINOCHOROIDOPATHY (disorder) | 1 | BeFree |