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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SMCP
check button Gene summary
Basic gene informationGene symbolSMCP
Gene namesperm mitochondria-associated cysteine-rich protein
SynonymsHSMCSGEN1|MCS|MCSP
CytomapUCSC genome browser: 1q21.3
Type of geneprotein-coding
RefGenesNM_030663.2,
Descriptionmitochondrial capsule selenoproteinsperm mitochondrial-associated cysteine-rich protein
Modification date20141207
dbXrefs MIM : 601148
HGNC : HGNC
Ensembl : ENSG00000163206
HPRD : 03093
Vega : OTTHUMG00000012452
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SMCP
BioGPS: 4184
PathwayNCI Pathway Interaction Database: SMCP
KEGG: SMCP
REACTOME: SMCP
Pathway Commons: SMCP
ContextiHOP: SMCP
ligand binding site mutation search in PubMed: SMCP
UCL Cancer Institute: SMCP
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of SMCP
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SMCP

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC-0.943904161-2.1394237691.1955196089.21E-062.10E-05
HNSC-0.95218656-2.0016656291.049479070.00110.003661243


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TissGene-miRNA for SMCP

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for SMCP
TissGeneSNV for SMCP

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.Q17XSKCM1
p.P92LUCEC1
p.C65YSTAD1
p.Q22LLIHC1
p.E88KBRCA1
p.C2SHNSC1
p.P92RUCS1
p.Q17*SKCM1
p.Q4LSTAD1
p.Q60HSARC1
p.P52QLUAD1
p.P82LSTAD1
p.C42YCESC1
p.E75QBLCA1


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TissGeneCNV for SMCP

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SMCP

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADB043882SMCP-C9orf43chr1:152857043chr9:116173207
Chimerdb3.0ChiTaRsNAAK058132SBNO2-SMCPchr19:1108816chr1:152850797
TCGAfusionPortalPRADABRCATCGA-A7-A4SF-01ABCL9-SMCP5UTR-5UTRChr1:147013444Chr1:152856879


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TissGeneNet for SMCP

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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COAD (tumor)COAD (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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HNSC (tumor)HNSC (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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KICH (tumor)KICH (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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KIRC (tumor)KIRC (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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KIRP (tumor)KIRP (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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LIHC (tumor)LIHC (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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LUAD (tumor)LUAD (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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LUSC (tumor)LUSC (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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PRAD (tumor)PRAD (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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STAD (tumor)STAD (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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THCA (tumor)THCA (normal)
SMCP, PLSCR1, KRTAP4-12 (tumor)SMCP, PLSCR1, KRTAP4-12 (normal)
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TissGeneProg for SMCP

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SMCP
TissGeneDrug for SMCP

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SMCP

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0025202melanoma3BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C0878544Cardiomyopathies2BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0023976Long QT Syndrome1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0041234Chagas Disease1BeFree
umls:C0410158Muscle damage1BeFree
umls:C0410179Scleroatonic muscular dystrophy1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1631597VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree