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| TissGeneSummary for TRPM1 |
 Gene summary |
| Basic gene information | Gene symbol | TRPM1 |
| Gene name | transient receptor potential cation channel, subfamily M, member 1 | |
| Synonyms | CSNB1C|LTRPC1|MLSN1 | |
| Cytomap | UCSC genome browser: 15q13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001252020.1, NM_001252024.1,NM_001252030.1,NM_002420.5, | |
| Description | long transient receptor potential channel 1melastatin-1transient receptor potential cation channel subfamily M member 1transient receptor potential melastatin family | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603576 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134160 | ||
| HPRD : 04656 | ||
| Vega : OTTHUMG00000129267 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TRPM1 | |
| BioGPS: 4308 | ||
| Pathway | NCI Pathway Interaction Database: TRPM1 | |
| KEGG: TRPM1 | ||
| REACTOME: TRPM1 | ||
| Pathway Commons: TRPM1 | ||
| Context | iHOP: TRPM1 | |
| ligand binding site mutation search in PubMed: TRPM1 | ||
| UCL Cancer Institute: TRPM1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMTGCT | |
| Reference showing the relevant tissue of TRPM1 | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0060402 | calcium ion transport into cytosol | 23452348 | GO:0060402 | calcium ion transport into cytosol | 23452348 |
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| TissGeneExp for TRPM1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -1.657025266 | -0.570397141 | -1.086628125 | 3.10E-06 | 1.42E-05 |
| LUAD | -2.381885503 | -1.195033779 | -1.186851724 | 2.12E-10 | 1.22E-09 |
| KICH | -2.128783641 | -0.688607641 | -1.440176 | 0.000337 | 0.000800375 |
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| TissGene-miRNA for TRPM1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TRPM1 |
| TissGeneSNV for TRPM1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R473C | UCEC | 2 |
| p.M996I | CESC | 2 |
| p.K1170R | THYM | 1 |
| p.Q1127H | LUAD | 1 |
| p.T1625I | PRAD | 1 |
| p.A451S | PCPG | 1 |
| p.R1567I | CESC | 1 |
| p.R1220H | LGG | 1 |
| p.F368L | LUAD | 1 |
| p.R760W | STAD | 1 |
| p.P58H | KIRP | 1 |
| p.E1189K | STAD | 1 |
| p.L1574Q | SKCM | 1 |
| p.R266Q | BLCA | 1 |
| p.L96Q | LUAD | 1 |
| p.Q1471* | UCEC | 1 |
| p.E702K | UCEC | 1 |
| p.G182D | STAD | 1 |
| p.C374Y | THYM | 1 |
| p.L795R | STAD | 1 |
| p.R1133Q | STAD | 1 |
| p.M151V | BLCA | 1 |
| p.R201Q | SKCM | 1 |
| p.V1163M | STAD | 1 |
| p.S22R | LUAD | 1 |
| p.P91L | STAD | 1 |
| p.S905Y | LUAD | 1 |
| p.R1176M | PAAD | 1 |
| p.V303F | LUAD | 1 |
| p.K590E | OV | 1 |
| p.Q391* | LUAD | 1 |
| p.M40I | COAD | 1 |
| p.V277E | LUAD | 1 |
| p.R201L | LUAD | 1 |
| p.R585H | SKCM | 1 |
| p.G1610V | LUAD | 1 |
| p.S1591T | LUAD | 1 |
| p.L345P | STAD | 1 |
| p.W1035* | HNSC | 1 |
| p.P1585T | SKCM | 1 |
| p.S1482F | SKCM | 1 |
| p.A1274V | CESC | 1 |
| p.L304F | PRAD | 1 |
| p.P446L | GBM | 1 |
| p.V1511D | LUAD | 1 |
| p.L500F | SKCM | 1 |
| p.N553H | STAD | 1 |
| p.E1204* | LUAD | 1 |
| p.L1021F | STAD | 1 |
| p.E1366K | LUAD | 1 |
| p.P650L | SKCM | 1 |
| p.Q391L | LUAD | 1 |
| p.R160I | LUAD | 1 |
| p.Q648H | PAAD | 1 |
| p.R1183L | BLCA | 1 |
| p.M1056I | LUAD | 1 |
| p.Q1493R | LUSC | 1 |
| p.S61R | LUAD | 1 |
| p.R512C | UCEC | 1 |
| p.C1471F | LUSC | 1 |
| p.Q101* | SKCM | 1 |
| p.M71T | STAD | 1 |
| p.I273T | SKCM | 1 |
| p.M1585V | BRCA | 1 |
| p.Q1493K | THYM | 1 |
| p.Q631H | PAAD | 1 |
| p.R956C | LUSC | 1 |
| p.P94S | SKCM | 1 |
| p.I1058T | LIHC | 1 |
| p.R806C | SKCM | 1 |
| p.K1349R | LUAD | 1 |
| p.P114T | LUAD | 1 |
| p.M1095I | LUAD | 1 |
| p.I1500V | HNSC | 1 |
| p.V369L | BLCA | 1 |
| p.A826S | LUAD | 1 |
| p.D1211E | SARC | 1 |
| p.S232F | COAD | 1 |
| p.A569D | BRCA | 1 |
| p.M110T | STAD | 1 |
| p.E347D | ESCA | 1 |
| p.P58S | SKCM | 1 |
| p.S1303F | UCEC | 1 |
| p.R1567I | ESCA | 1 |
| p.E694K | PRAD | 1 |
| p.D893A | SKCM | 1 |
| p.V303I | LGG | 1 |
| p.R1222L | LUAD | 1 |
| p.R1207L | LUAD | 1 |
| p.V220I | LUAD | 1 |
| p.E913K | SKCM | 1 |
| p.L1110M | LUAD | 1 |
| p.V575M | ESCA | 1 |
| p.D93N | READ | 1 |
| p.G1394D | DLBC | 1 |
| p.G476R | SKCM | 1 |
| p.P798L | OV | 1 |
| p.K1412N | LIHC | 1 |
| p.P297S | SKCM | 1 |
| p.S1589* | GBM | 1 |
| p.A331E | LUAD | 1 |
| p.L306P | STAD | 1 |
| p.P52L | STAD | 1 |
| p.N342D | SKCM | 1 |
| p.L349F | CESC | 1 |
| p.G856R | COAD | 1 |
| p.G188W | PRAD | 1 |
| p.I940F | LIHC | 1 |
| p.V260M | STAD | 1 |
| p.V482E | KIRP | 1 |
| p.A681T | LGG | 1 |
| p.V292M | KIRC | 1 |
| p.E1405K | LUAD | 1 |
| p.R806C | COAD | 1 |
| p.E150Q | BLCA | 1 |
| p.R1094Q | STAD | 1 |
| p.E343* | LUAD | 1 |
| p.W1089L | LUAD | 1 |
| p.R1287Q | SKCM | 1 |
| p.V292L | LUAD | 1 |
| p.Y1413C | HNSC | 1 |
| p.L1587V | LUSC | 1 |
| p.L611R | ESCA | 1 |
| p.R199I | LUAD | 1 |
| p.E304* | LUAD | 1 |
| p.G468E | SKCM | 1 |
| p.E1639X | COAD | 1 |
| p.A945V | LIHC | 1 |
| p.M1044T | UCEC | 1 |
| p.I969V | LUAD | 1 |
| p.A911V | COAD | 1 |
| p.R1461H | STAD | 1 |
| p.A945D | ESCA | 1 |
| p.E484K | SKCM | 1 |
| p.D1174A | SKCM | 1 |
| p.W996* | HNSC | 1 |
| p.R489G | UCEC | 1 |
| p.Q1088H | LUAD | 1 |
| p.G476W | ACC | 1 |
| p.R1299W | GBM | 1 |
| p.L912X | KIRP | 1 |
| p.G1448D | STAD | 1 |
| p.R1422H | STAD | 1 |
| p.E1466K | BLCA | 1 |
| p.S82Y | STAD | 1 |
| p.L967P | STAD | 1 |
| p.R450G | UCEC | 1 |
| p.R928L | LUAD | 1 |
| p.R1222L | BLCA | 1 |
| p.V482L | BLCA | 1 |
| p.T1443K | LUSC | 1 |
| p.A1102P | SKCM | 1 |
| p.S1552T | LUAD | 1 |
| p.E1280* | UCEC | 1 |
| p.D514N | COAD | 1 |
| p.P1418S | SKCM | 1 |
| p.C1084S | LUAD | 1 |
| p.V439G | UCEC | 1 |
| p.T1507M | LGG | 1 |
| p.R555W | STAD | 1 |
| p.R721W | STAD | 1 |
| p.E68K | SKCM | 1 |
| p.S1476C | LUAD | 1 |
| p.V1202M | STAD | 1 |
| p.S628I | PAAD | 1 |
| p.H272Y | LUAD | 1 |
| p.S1123L | HNSC | 1 |
| p.A1512T | UCEC | 1 |
| p.G160V | ESCA | 1 |
| p.P1028S | UCEC | 1 |
| p.S344F | SKCM | 1 |
| p.P153T | LUAD | 1 |
| p.D93Y | LGG | 1 |
| p.S1437C | LUAD | 1 |
| p.D1004N | LGG | 1 |
| p.S908F | UCEC | 1 |
| p.W671C | LUAD | 1 |
| p.R31L | LUAD | 1 |
| p.S72R | PAAD | 1 |
| p.D385Y | UCEC | 1 |
| p.G754E | UCEC | 1 |
| p.G206R | LGG | 1 |
| p.S1279C | CESC | 1 |
| p.S89R | PAAD | 1 |
| p.Q1175K | SKCM | 1 |
| p.Q101X | SKCM | 1 |
| p.E310* | LUAD | 1 |
| p.R113H | GBM | 1 |
| p.K686T | ESCA | 1 |
| p.K604T | STAD | 1 |
| p.R512C | COAD | 1 |
| p.R1163C | PAAD | 1 |
| p.E294K | BLCA | 1 |
| p.Q1580K | ESCA | 1 |
| p.K589R | STAD | 1 |
| p.G1409D | STAD | 1 |
| p.V299M | STAD | 1 |
| p.P1555L | SKCM | 1 |
| p.L1006P | STAD | 1 |
| p.N242K | LUAD | 1 |
| p.L756R | STAD | 1 |
| p.E271* | LUAD | 1 |
| p.Y1026C | PAAD | 1 |
| p.R1559H | LUAD | 1 |
| p.L573V | HNSC | 1 |
| p.D1484N | UCEC | 1 |
| p.N203K | LUAD | 1 |
| p.V316E | LUAD | 1 |
| p.V423M | PRAD | 1 |
| p.M1002L | DLBC | 1 |
| p.R590Q | UCEC | 1 |
| p.W381* | UCEC | 1 |
| p.K628R | STAD | 1 |
| p.R1556* | BLCA | 1 |
| p.K1447N | UCEC | 1 |
| p.S196P | SARC | 1 |
| p.R1180C | PAAD | 1 |
| p.T246I | STAD | 1 |
| p.L552R | SKCM | 1 |
| p.E1203K | UCEC | 1 |
| p.A261T | COAD | 1 |
| p.A836D | LUSC | 1 |
| p.L1021F | BRCA | 1 |
| p.G817* | UCEC | 1 |
| p.E347D | LUSC | 1 |
| p.K662E | SKCM | 1 |
| p.D1188N | LIHC | 1 |
| p.V408L | BLCA | 1 |
| p.V976M | HNSC | 1 |
| p.I1461V | HNSC | 1 |
| p.S645I | PAAD | 1 |
| p.E1261Q | BLCA | 1 |
| p.K626N | CESC | 1 |
| p.A1274V | BLCA | 1 |
| p.S282I | UCEC | 1 |
| p.L101F | CESC | 1 |
| p.R1080Q | COAD | 1 |
| p.N592H | STAD | 1 |
| p.S55Y | HNSC | 1 |
| p.V1015M | HNSC | 1 |
| p.A865S | LUAD | 1 |
| p.P1464S | LUAD | 1 |
| p.E1639K | LUSC | 1 |
| p.W862* | UCEC | 1 |
| p.Y1043C | PAAD | 1 |
| p.R512L | SKCM | 1 |
| p.Y1452C | HNSC | 1 |
| p.P1029S | SKCM | 1 |
| p.K192R | PRAD | 1 |
| p.L612V | HNSC | 1 |
| p.M112V | BLCA | 1 |
| p.R1193M | PAAD | 1 |
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| TissGeneCNV for TRPM1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TRPM1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for TRPM1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TRPM1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TRPM1 |
| TissGeneDrug for TRPM1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TRPM1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0025202 | melanoma | 13 | BeFree |
| umls:C0339535 | Night blindness, congenital stationary | 8 | BeFree,ORPHANET |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 3 | BeFree |
| umls:C2750747 | NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1C | 3 | CLINVAR,CTD_human,UNIPROT |
| umls:C0278883 | Metastatic melanoma | 2 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0346041 | Tumor of dermis | 1 | BeFree |
| umls:C0549567 | Pigmentation Disorders | 1 | BeFree |
| umls:C0730308 | Melanoma-Associated Retinopathy | 1 | BeFree |
| umls:C1704421 | Skin Pigmentation Disorder | 1 | BeFree |
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