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| TissGeneSummary for MUC5AC |
 Gene summary |
| Basic gene information | Gene symbol | MUC5AC |
| Gene name | mucin 5AC, oligomeric mucus/gel-forming | |
| Synonyms | MUC5|TBM|leB | |
| Cytomap | UCSC genome browser: 11p15.5 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017511.1, | |
| Description | gastric mucinlewis B blood group antigenmajor airway glycoproteinmucin 5, subtypes A and C, tracheobronchial/gastricmucin 5AC, oligomeric mucus/gel-forming pseudogenemucin-5 subtype AC, tracheobronchialtracheobronchial mucin | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 158373 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000215182 | ||
| Vega : OTTHUMG00000154270 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MUC5AC | |
| BioGPS: 4586 | ||
| Pathway | NCI Pathway Interaction Database: MUC5AC | |
| KEGG: MUC5AC | ||
| REACTOME: MUC5AC | ||
| Pathway Commons: MUC5AC | ||
| Context | iHOP: MUC5AC | |
| ligand binding site mutation search in PubMed: MUC5AC | ||
| UCL Cancer Institute: MUC5AC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of MUC5AC | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0043206 | extracellular fibril organization | 10611155 | GO:0043206 | extracellular fibril organization | 10611155 |
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| TissGeneExp for MUC5AC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for MUC5AC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for MUC5AC |
| TissGeneSNV for MUC5AC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S346F | SKCM | 1 |
| p.P221S | SKCM | 1 |
| p.E116K | ESCA | 1 |
| p.T239M | PRAD | 1 |
| p.W209L | LUAD | 1 |
| p.569_569insE | SKCM | 1 |
| p.D291G | PAAD | 1 |
| p.569_569insG | SKCM | 1 |
| p.F330L | BLCA | 1 |
| p.R213W | HNSC | 1 |
| p.G135S | SKCM | 1 |
| p.602_602insV | LUAD | 1 |
| p.G435E | SKCM | 1 |
| p.W182* | SKCM | 1 |
| p.614_614insC | SKCM | 1 |
| p.G126V | LIHC | 1 |
| p.F553L | LUAD | 1 |
| p.G320E | HNSC | 1 |
| p.P168L | HNSC | 1 |
| p.H131Q | LUAD | 1 |
| p.597_597insL | LUAD | 1 |
| p.591_591insT | UVM | 1 |
| p.R219Q | SKCM | 1 |
| p.R233W | SKCM | 1 |
| p.A114T | LGG | 1 |
| p.A202T | HNSC | 1 |
| p.P44S | SKCM | 1 |
| p.D29N | SKCM | 1 |
| p.T122M | PAAD | 1 |
| p.E133D | BLCA | 1 |
| p.A57V | PCPG | 1 |
| p.579_579insF | SKCM | 1 |
| p.591_591insT | ESCA | 1 |
| p.Q510* | LUAD | 1 |
| p.E424K | SKCM | 1 |
| p.P156S | LUAD | 1 |
| p.F87V | SARC | 1 |
| p.P257L | SKCM | 1 |
| p.A591T | UVM | 1 |
| p.H306Q | LUAD | 1 |
| p.L222H | HNSC | 1 |
| p.A57E | LUAD | 1 |
| p.A161V | STAD | 1 |
| p.W12* | LUAD | 1 |
| p.A401T | PAAD | 1 |
| p.P428L | HNSC | 1 |
| p.P516A | LGG | 1 |
| p.P168S | HNSC | 1 |
| p.614_614insS | LIHC | 1 |
| p.P402S | SKCM | 1 |
| p.P328T | LUAD | 1 |
| p.A75S | LGG | 1 |
| p.E362D | HNSC | 1 |
| p.S432F | BLCA | 1 |
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| TissGeneCNV for MUC5AC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for MUC5AC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-44-6146-01A | PIGR-MUC5AC | Out-of-Frame | chr1:207108047 | chr11:1213023 |
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| TissGeneNet for MUC5AC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for MUC5AC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for MUC5AC |
| TissGeneDrug for MUC5AC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for MUC5AC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 16 | BeFree,GAD,LHGDN,RGD |
| umls:C0699791 | Stomach Carcinoma | 16 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 15 | BeFree |
| umls:C0001418 | Adenocarcinoma | 12 | BeFree,LHGDN |
| umls:C0235974 | Pancreatic carcinoma | 12 | BeFree |
| umls:C0032584 | polyps | 10 | BeFree,LHGDN |
| umls:C0346647 | Malignant neoplasm of pancreas | 10 | BeFree |
| umls:C0027430 | Nasal Polyps | 9 | BeFree |
| umls:C0001430 | Adenoma | 8 | BeFree,LHGDN |
| umls:C0007130 | Mucinous Adenocarcinoma | 7 | BeFree,LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 7 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 7 | BeFree |
| umls:C0596263 | Carcinogenesis | 7 | BeFree |
| umls:C0029882 | Otitis Media | 6 | BeFree,GAD,RGD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 5 | BeFree,LHGDN,RGD |
| umls:C0878500 | Intraepithelial Neoplasia | 5 | BeFree |
| umls:C1527249 | Colorectal Cancer | 5 | BeFree |
| umls:C2987191 | Pancreatic Intraductal Papillary Mucinous Neoplasm, Gastric-Type | 5 | BeFree |
| umls:C0024115 | Lung diseases | 4 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0149516 | Chronic sinusitis | 4 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 4 | BeFree |
| umls:C2827407 | Infectious Otitis Media | 4 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
| umls:C0010278 | Craniosynostosis | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 3 | BeFree |
| umls:C0013238 | Dry Eye Syndromes | 3 | BeFree,RGD |
| umls:C0030297 | Pancreatic Neoplasm | 3 | BeFree,LHGDN |
| umls:C0038354 | Stomach Diseases | 3 | BeFree,RGD |
| umls:C0038356 | Stomach Neoplasms | 3 | LHGDN |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C0699790 | Colon Carcinoma | 3 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 3 | BeFree |
| umls:C1301034 | Pancreatic intraepithelial neoplasia | 3 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 2 | LHGDN |
| umls:C0017152 | Gastritis | 2 | BeFree |
| umls:C0017168 | Gastroesophageal reflux disease | 2 | BeFree |
| umls:C0029883 | Otitis Media with Effusion | 2 | BeFree,GAD |
| umls:C0033822 | Pseudomyxoma Peritonei | 2 | BeFree |
| umls:C0035204 | Respiration Disorders | 2 | BeFree |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 2 | BeFree,GAD |
| umls:C0035242 | Respiratory Tract Diseases | 2 | BeFree |
| umls:C0037199 | Sinusitis | 2 | BeFree |
| umls:C0038358 | Gastric ulcer | 2 | RGD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0206674 | Adenoma, Villous | 2 | BeFree |
| umls:C0242216 | Biliary calculi | 2 | LHGDN |
| umls:C0333983 | Hyperplastic Polyp | 2 | BeFree |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 2 | BeFree |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 2 | BeFree |
| umls:C0747085 | Otitis media recurrent | 2 | BeFree |
| umls:C0887833 | Carcinoma, Pancreatic Ductal | 2 | BeFree,LHGDN |
| umls:C1274788 | Atopic keratoconjunctivitis | 2 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 2 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 2 | BeFree |
| umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 2 | BeFree |
| umls:C1527336 | Sjogren's Syndrome | 2 | BeFree |
| umls:C1557335 | Ocular surface disease | 2 | BeFree |
| umls:C1561989 | Limbal stem cell deficiency | 2 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 2 | BeFree,RGD |
| umls:C0003864 | Arthritis | 1 | BeFree,LHGDN |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree |
| umls:C0004763 | Barrett Esophagus | 1 | BeFree |
| umls:C0005398 | Cholestasis, Extrahepatic | 1 | BeFree |
| umls:C0005426 | Biliary Tract Neoplasm | 1 | LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 1 | GAD |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0006277 | Bronchitis | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0008677 | Bronchitis, Chronic | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
| umls:C0010631 | Cystadenocarcinoma | 1 | BeFree |
| umls:C0010635 | Cystadenoma, Mucinous | 1 | BeFree |
| umls:C0010692 | Cystitis | 1 | LHGDN |
| umls:C0020507 | Hyperplasia | 1 | LHGDN |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0023067 | Laryngitis | 1 | LHGDN |
| umls:C0024232 | Lymphatic Metastasis | 1 | LHGDN |
| umls:C0027149 | Myxoma | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0032227 | Pleural effusion disorder | 1 | BeFree |
| umls:C0032269 | Pneumococcal Infections | 1 | LHGDN |
| umls:C0032285 | Pneumonia | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0034063 | Pulmonary Edema | 1 | BeFree |
| umls:C0034069 | Pulmonary Fibrosis | 1 | RGD |
| umls:C0035455 | Rhinitis | 1 | RGD |
| umls:C0041582 | Ulcer | 1 | LHGDN |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0080032 | Pleural Effusion, Malignant | 1 | BeFree |
| umls:C0086448 | Ileoanal Pouches | 1 | BeFree |
| umls:C0149520 | Acute Cholecystitis | 1 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0205645 | Adenocarcinoma, Tubular | 1 | BeFree |
| umls:C0205699 | Carcinomatosis | 1 | BeFree |
| umls:C0206677 | Adenomatous Polyps | 1 | BeFree |
| umls:C0206687 | Carcinoma, Endometrioid | 1 | BeFree |
| umls:C0206692 | Carcinoma, Lobular | 1 | LHGDN |
| umls:C0221273 | Juvenile polyp | 1 | BeFree |
| umls:C0238339 | Hereditary pancreatitis | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242656 | Disease Progression | 1 | LHGDN |
| umls:C0265325 | Turcot syndrome (disorder) | 1 | BeFree |
| umls:C0270246 | Meconium plug syndrome | 1 | BeFree |
| umls:C0276623 | Chronic viral hepatitis | 1 | BeFree |
| umls:C0276919 | Intestinal nematode infection | 1 | BeFree |
| umls:C0278803 | Adenocarcinoma of small intestine | 1 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree |
| umls:C0302358 | Disease caused by Shigella dysenteriae | 1 | BeFree |
| umls:C0314719 | Dryness of eye | 1 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 1 | BeFree |
| umls:C0345893 | Juvenile polyposis syndrome | 1 | BeFree |
| umls:C0392164 | Pulmonary Cystic Fibrosis | 1 | BeFree |
| umls:C0392707 | Atopy | 1 | GAD |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0546982 | Cystic fibrosis with meconium ileus | 1 | BeFree |
| umls:C0555971 | Oral infection | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699949 | airway disease | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C0948780 | Rhinosinusitis | 1 | BeFree |
| umls:C0949059 | Polyp of large intestine | 1 | BeFree |
| umls:C1266035 | Bronchiolo-alveolar carcinoma, mucinous | 1 | BeFree |
| umls:C1334811 | Mucinous Neoplasm | 1 | BeFree |
| umls:C1513718 | Mucin-Producing Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C1535939 | Pneumocystis jiroveci pneumonia | 1 | BeFree |
| umls:C2939175 | Meconium ileus | 1 | BeFree |
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