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| TissGeneSummary for CEACAM6 |
 Gene summary |
| Basic gene information | Gene symbol | CEACAM6 |
| Gene name | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | |
| Synonyms | CD66c|CEAL|NCA | |
| Cytomap | UCSC genome browser: 19q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002483.6, | |
| Description | Cluster of Differentiation 66ccarcinoembryonic antigen-related cell adhesion molecule 6normal cross-reacting antigen | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 163980 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000086548 | ||
| HPRD : 01233 | ||
| Vega : OTTHUMG00000151064 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CEACAM6 | |
| BioGPS: 4680 | ||
| Pathway | NCI Pathway Interaction Database: CEACAM6 | |
| KEGG: CEACAM6 | ||
| REACTOME: CEACAM6 | ||
| Pathway Commons: CEACAM6 | ||
| Context | iHOP: CEACAM6 | |
| ligand binding site mutation search in PubMed: CEACAM6 | ||
| UCL Cancer Institute: CEACAM6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADLUAD,LUSC | |
| Reference showing the relevant tissue of CEACAM6 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CEACAM6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 2.558001665 | -0.740770265 | 3.29877193 | 1.34E-15 | 7.24E-15 |
| THCA | -1.027810081 | -4.687349064 | 3.659538983 | 8.00E-11 | 5.40E-10 |
| LUSC | 3.255642429 | 6.858693409 | -3.60305098 | 3.65E-13 | 1.78E-12 |
| HNSC | 3.423263313 | 5.727814476 | -2.304551163 | 1.05E-07 | 1.02E-06 |
| ESCA | 6.532659719 | 1.079014265 | 5.453645455 | 0.000593 | 0.010144862 |
| COAD | 7.800201327 | 6.555685943 | 1.244515385 | 0.000151 | 0.000525144 |
| LIHC | -5.533362826 | -3.086594826 | -2.446768 | 2.98E-05 | 0.000114113 |
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| TissGene-miRNA for CEACAM6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CEACAM6 |
| TissGeneSNV for CEACAM6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E168K | SKCM | 3 |
| p.R62C | SKCM | 3 |
| p.P8L | SKCM | 2 |
| p.A322S | LUAD | 1 |
| p.R207K | SKCM | 1 |
| p.S270F | SKCM | 1 |
| p.P142S | BRCA | 1 |
| p.P14T | PRAD | 1 |
| p.I242V | UCEC | 1 |
| p.D74N | SKCM | 1 |
| p.R10K | CESC | 1 |
| p.Y249* | LIHC | 1 |
| p.P237R | LUSC | 1 |
| p.K160N | SKCM | 1 |
| p.A94T | KIRP | 1 |
| p.E170K | BLCA | 1 |
| p.P220T | THYM | 1 |
| p.T334M | BRCA | 1 |
| p.V318F | PAAD | 1 |
| p.T135N | LUSC | 1 |
| p.P189S | UCEC | 1 |
| p.Q218H | BLCA | 1 |
| p.T121I | SKCM | 1 |
| p.S296F | SKCM | 1 |
| p.S106F | SKCM | 1 |
| p.P287S | SKCM | 1 |
| p.L257I | STAD | 1 |
| p.P142T | KIRP | 1 |
| p.N115S | HNSC | 1 |
| p.F277L | UCEC | 1 |
| p.I289T | LIHC | 1 |
| p.S326L | LUAD | 1 |
| p.S326P | ACC | 1 |
| p.R62H | HNSC | 1 |
| p.R207M | UCEC | 1 |
| p.T330I | SKCM | 1 |
| p.P251S | SKCM | 1 |
| p.Q137R | PAAD | 1 |
| p.A305T | LUAD | 1 |
| p.A55V | SKCM | 1 |
| p.P244L | SKCM | 1 |
| p.Y249X | LIHC | 1 |
| p.P3L | LGG | 1 |
| p.S270T | COAD | 1 |
| p.G85E | DLBC | 1 |
| p.S188T | LUSC | 1 |
| p.L129I | PRAD | 1 |
| p.R310S | LUAD | 1 |
| p.N155K | SKCM | 1 |
| p.G118E | UCEC | 1 |
| p.Y82D | UCEC | 1 |
| p.E170Q | BLCA | 1 |
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| TissGeneCNV for CEACAM6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CEACAM6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF744189 | CEACAM6-ZNF37A | chr19:42274774 | chr10:38411258 | |
| Chimerdb3.0 | ChiTaRs | NA | BG953926 | CEACAM6-CAPN5 | chr19:42260599 | chr11:76828675 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | MAP1S-CEACAM6 | Out-of-Frame | chr19:17835017 | chr19:42270090 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | MAP1S-CEACAM6 | In-Frame | chr19:17831846 | chr19:42270090 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | MAP1S-CEACAM6 | CDS-3'UTR | chr19:17835017 | chr19:42274706 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A891-01A | MAP1S-CEACAM6 | CDS-3'UTR | chr19:17831846 | chr19:42274706 |
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| TissGeneNet for CEACAM6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| COAD (tumor) | COAD (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| STAD (tumor) | STAD (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| THCA (tumor) | THCA (normal) |
| CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (tumor) | CEACAM6, CEACAM5, CEACAM1, CARTPT, CEACAM7, CEACAM8 (normal) |
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| TissGeneProg for CEACAM6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CEACAM6 |
| TissGeneDrug for CEACAM6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CEACAM6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027627 | Neoplasm Metastasis | 10 | BeFree |
| umls:C0699790 | Colon Carcinoma | 10 | BeFree |
| umls:C0001418 | Adenocarcinoma | 7 | BeFree,LHGDN |
| umls:C0009402 | Colorectal Carcinoma | 7 | BeFree |
| umls:C0010346 | Crohn Disease | 7 | BeFree,LHGDN |
| umls:C0281361 | Adenocarcinoma of pancreas | 6 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 5 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 5 | BeFree |
| umls:C1527249 | Colorectal Cancer | 5 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 3 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0009319 | Colitis | 2 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0919267 | ovarian neoplasm | 2 | BeFree,LHGDN |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 2 | BeFree |
| umls:C1960397 | Philadelphia chromosome-positive acute lymphoblastic leukemia | 2 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | BeFree,LHGDN |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0001486 | Adenovirus Infections | 1 | BeFree |
| umls:C0001815 | Primary Myelofibrosis | 1 | BeFree |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 1 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
| umls:C0023486 | Prolymphocytic Leukemia | 1 | BeFree |
| umls:C0024115 | Lung diseases | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0025303 | Meningococcal Infections | 1 | GAD |
| umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0334307 | Tubulovillous adenoma | 1 | BeFree |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0700361 | Emotional distress | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
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