TissGeneSummary for FXYD2 |
Gene summary |
Basic gene information | Gene symbol | FXYD2 |
Gene name | FXYD domain containing ion transport regulator 2 | |
Synonyms | ATP1G1|HOMG2 | |
Cytomap | UCSC genome browser: 11q23 | |
Type of gene | protein-coding | |
RefGenes | NM_001680.4, NM_021603.3,NM_001127489.1, | |
Description | ATPase, Na+/K+ transporting, gamma 1 polypeptideNa(+)/K(+) ATPase subunit gammasodium pump gamma chainsodium/potassium-transporting ATPase subunit gamma | |
Modification date | 20141207 | |
dbXrefs | MIM : 601814 | |
HGNC : HGNC | ||
Ensembl : ENSG00000137731 | ||
HPRD : 03487 | ||
Vega : OTTHUMG00000166990 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FXYD2 | |
BioGPS: 486 | ||
Pathway | NCI Pathway Interaction Database: FXYD2 | |
KEGG: FXYD2 | ||
REACTOME: FXYD2 | ||
Pathway Commons: FXYD2 | ||
Context | iHOP: FXYD2 | |
ligand binding site mutation search in PubMed: FXYD2 | ||
UCL Cancer Institute: FXYD2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of FXYD2 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FXYD2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.225058785 | -1.113088609 | -1.111970175 | 1.89E-14 | 9.53E-14 |
KIRC | 8.969750426 | 10.0601532 | -1.090402778 | 9.69E-08 | 2.71E-07 |
KIRP | 8.840561884 | 10.51500251 | -1.674440625 | 4.33E-06 | 1.93E-05 |
PRAD | -2.729420087 | -1.689602779 | -1.039817308 | 2.21E-06 | 1.45E-05 |
HNSC | -1.260364497 | 0.185347131 | -1.445711628 | 0.00939 | 0.023501112 |
BLCA | -1.916625451 | -0.861362293 | -1.055263158 | 0.00178 | 0.011575205 |
LIHC | 1.817490759 | 4.452378759 | -2.634888 | 7.99E-05 | 0.000282576 |
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TissGene-miRNA for FXYD2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UVM | hsa-miR-34a-5p | MIMAT0000255 | 0.0014 | -0.35 | 80 |
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TissGeneMut for FXYD2 |
TissGeneSNV for FXYD2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R28H | UCEC | 1 |
p.R59K | OV | 1 |
p.R57K | ACC | 1 |
p.G61C | UCEC | 1 |
p.G64R | UCEC | 1 |
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TissGeneCNV for FXYD2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FXYD2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | X86400 | FXYD2-UBR3 | chr11:117695434 | chr2:170894695 |
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TissGeneNet for FXYD2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FXYD2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FXYD2 |
TissGeneDrug for FXYD2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00606 | Cyclothiazide | Inhibitor | Small molecule | Approved |
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TissGeneDisease for FXYD2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020599 | Hypocalciuria | 4 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | CTD_human |
umls:C0024473 | Magnesium Deficiency | 1 | CTD_human |
umls:C0268448 | Primary hypomagnesemia (disorder) | 1 | CTD_human |
umls:C0342276 | Maturity onset diabetes mellitus in young | 1 | BeFree |
umls:C0553730 | Calcium pyrophosphate deposition disease | 1 | BeFree |
umls:C1835171 | Hypomagnesemia 2, renal | 1 | CTD_human,ORPHANET,UNIPROT |