TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FXYD2
check button Gene summary
Basic gene informationGene symbolFXYD2
Gene nameFXYD domain containing ion transport regulator 2
SynonymsATP1G1|HOMG2
CytomapUCSC genome browser: 11q23
Type of geneprotein-coding
RefGenesNM_001680.4,
NM_021603.3,NM_001127489.1,
DescriptionATPase, Na+/K+ transporting, gamma 1 polypeptideNa(+)/K(+) ATPase subunit gammasodium pump gamma chainsodium/potassium-transporting ATPase subunit gamma
Modification date20141207
dbXrefs MIM : 601814
HGNC : HGNC
Ensembl : ENSG00000137731
HPRD : 03487
Vega : OTTHUMG00000166990
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FXYD2
BioGPS: 486
PathwayNCI Pathway Interaction Database: FXYD2
KEGG: FXYD2
REACTOME: FXYD2
Pathway Commons: FXYD2
ContextiHOP: FXYD2
ligand binding site mutation search in PubMed: FXYD2
UCL Cancer Institute: FXYD2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Kidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)KIRC,KIRP,KICH
Reference showing the relevant tissue of FXYD2
Description by TissGene annotationsProtective TissGene in OS
Protective TissGene in RFS
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for FXYD2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA-2.225058785-1.113088609-1.1119701751.89E-149.53E-14
KIRC8.96975042610.0601532-1.0904027789.69E-082.71E-07
KIRP8.84056188410.51500251-1.6744406254.33E-061.93E-05
PRAD-2.729420087-1.689602779-1.0398173082.21E-061.45E-05
HNSC-1.2603644970.185347131-1.4457116280.009390.023501112
BLCA-1.916625451-0.861362293-1.0552631580.001780.011575205
LIHC1.8174907594.452378759-2.6348887.99E-050.000282576


Top
TissGene-miRNA for FXYD2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UVMhsa-miR-34a-5pMIMAT00002550.0014-0.3580


Top
TissGeneMut for FXYD2
TissGeneSNV for FXYD2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R28HUCEC1
p.R59KOV1
p.R57KACC1
p.G61CUCEC1
p.G64RUCEC1


Top
TissGeneCNV for FXYD2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for FXYD2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAX86400FXYD2-UBR3chr11:117695434chr2:170894695


Top
TissGeneNet for FXYD2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
FXYD2, ATP1A1 (tumor)FXYD2, ATP1A1 (normal)
bullet pointbullet point


Top
TissGeneProg for FXYD2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for FXYD2
TissGeneDrug for FXYD2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00606CyclothiazideInhibitorSmall moleculeApproved


Top
TissGeneDisease for FXYD2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020599Hypocalciuria4BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0020538Hypertensive disease1CTD_human
umls:C0024473Magnesium Deficiency1CTD_human
umls:C0268448Primary hypomagnesemia (disorder)1CTD_human
umls:C0342276Maturity onset diabetes mellitus in young1BeFree
umls:C0553730Calcium pyrophosphate deposition disease1BeFree
umls:C1835171Hypomagnesemia 2, renal1CTD_human,ORPHANET,UNIPROT