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| TissGeneSummary for ATP4A |
 Gene summary |
| Basic gene information | Gene symbol | ATP4A |
| Gene name | ATPase, H+/K+ exchanging, alpha polypeptide | |
| Synonyms | ATP6A | |
| Cytomap | UCSC genome browser: 19q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000704.2, | |
| Description | ATPase, H+/K+ transporting, alpha polypeptideH(+)-K(+)-ATPase alpha subunitgastric H(+)/K(+) ATPase subunit alphagastric H+/K+ ATPase alpha subunitgastric H,K-ATPase alpha subunitgastric H,K-ATPase catalytic subunitgastric hydrogen-potassium ATPase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 137216 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105675 | ||
| HPRD : 00668 | ||
| Vega : OTTHUMG00000048106 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ATP4A | |
| BioGPS: 495 | ||
| Pathway | NCI Pathway Interaction Database: ATP4A | |
| KEGG: ATP4A | ||
| REACTOME: ATP4A | ||
| Pathway Commons: ATP4A | ||
| Context | iHOP: ATP4A | |
| ligand binding site mutation search in PubMed: ATP4A | ||
| UCL Cancer Institute: ATP4A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of ATP4A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ATP4A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -0.096723153 | 1.55341583 | -1.650138983 | 9.52E-09 | 4.76E-08 |
| LUSC | -0.758926443 | -2.251024482 | 1.492098039 | 1.33E-06 | 3.29E-06 |
| ESCA | -2.137805587 | 8.279748958 | -10.41755455 | 0.00236 | 0.024993524 |
| BLCA | -0.608214678 | -2.251409415 | 1.643194737 | 0.00441 | 0.024157241 |
| STAD | 0.328794697 | 4.390419697 | -4.061625 | 0.00208 | 0.009412314 |
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| TissGene-miRNA for ATP4A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ATP4A |
| TissGeneSNV for ATP4A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V265A | COAD | 3 |
| p.G727R | SKCM | 2 |
| p.A144E | HNSC | 1 |
| p.A613D | COAD | 1 |
| p.R280H | UCEC | 1 |
| p.G476D | STAD | 1 |
| p.A149V | PAAD | 1 |
| p.E822K | SKCM | 1 |
| p.P706R | SKCM | 1 |
| p.Q957X | THYM | 1 |
| p.D583N | LIHC | 1 |
| p.R330Q | PAAD | 1 |
| p.A70S | LUAD | 1 |
| p.G896R | SKCM | 1 |
| p.E300K | SKCM | 1 |
| p.K964T | LUSC | 1 |
| p.D54N | SKCM | 1 |
| p.R668H | STAD | 1 |
| p.E298K | SKCM | 1 |
| p.E298K | STAD | 1 |
| p.N6K | UCEC | 1 |
| p.A466V | UCEC | 1 |
| p.E345Q | LUAD | 1 |
| p.W999R | UCEC | 1 |
| p.G37S | BRCA | 1 |
| p.A180V | GBM | 1 |
| p.A23T | SKCM | 1 |
| p.M602I | THYM | 1 |
| p.Q707* | SKCM | 1 |
| p.A4V | LGG | 1 |
| p.Q56E | LUSC | 1 |
| p.V101D | LUAD | 1 |
| p.I145V | THCA | 1 |
| p.D583N | SKCM | 1 |
| p.A586V | STAD | 1 |
| p.S418L | BLCA | 1 |
| p.V809M | STAD | 1 |
| p.E650K | GBM | 1 |
| p.A170T | HNSC | 1 |
| p.C242* | LUAD | 1 |
| p.V725I | LGG | 1 |
| p.T950K | LIHC | 1 |
| p.A282E | KIRP | 1 |
| p.C113* | LUAD | 1 |
| p.L845M | LGG | 1 |
| p.A331D | PAAD | 1 |
| p.R95W | OV | 1 |
| p.P800L | LUAD | 1 |
| p.M397I | COAD | 1 |
| p.P1003H | TGCT | 1 |
| p.R330W | UCEC | 1 |
| p.F979L | LUAD | 1 |
| p.K949E | COAD | 1 |
| p.R215L | LUSC | 1 |
| p.R922H | COAD | 1 |
| p.A597V | SKCM | 1 |
| p.S356F | SKCM | 1 |
| p.A307T | LIHC | 1 |
| p.A127V | ESCA | 1 |
| p.R694H | HNSC | 1 |
| p.P240H | COAD | 1 |
| p.D781N | READ | 1 |
| p.E822K | UCEC | 1 |
| p.E538G | LIHC | 1 |
| p.Q886K | COAD | 1 |
| p.Q266K | LUSC | 1 |
| p.A321V | SKCM | 1 |
| p.R694H | UCEC | 1 |
| p.A310T | STAD | 1 |
| p.V353G | STAD | 1 |
| p.Y927C | COAD | 1 |
| p.D853Y | LUAD | 1 |
| p.R703C | LUAD | 1 |
| p.R510W | COAD | 1 |
| p.D508V | LIHC | 1 |
| p.D751N | PAAD | 1 |
| p.R952H | STAD | 1 |
| p.R848S | LUAD | 1 |
| p.A721V | STAD | 1 |
| p.T931I | SKCM | 1 |
| p.I989M | BLCA | 1 |
| p.P847S | LUAD | 1 |
| p.M587T | KIRC | 1 |
| p.P211L | SKCM | 1 |
| p.R92Q | STAD | 1 |
| p.A899V | SARC | 1 |
| p.T243M | SKCM | 1 |
| p.R251H | BRCA | 1 |
| p.R330W | BLCA | 1 |
| p.M587I | KIRC | 1 |
| p.R215C | STAD | 1 |
| p.K616R | STAD | 1 |
| p.K793M | SKCM | 1 |
| p.R607Q | STAD | 1 |
| p.L201P | LIHC | 1 |
| p.A23D | THYM | 1 |
| p.G19S | SKCM | 1 |
| p.A870T | COAD | 1 |
| p.A282T | STAD | 1 |
| p.R658C | STAD | 1 |
| p.D670H | KIRC | 1 |
| p.V368M | LUAD | 1 |
| p.A296T | UCEC | 1 |
| p.A254T | PRAD | 1 |
| p.I741N | LGG | 1 |
| p.K669T | ESCA | 1 |
| p.A374V | STAD | 1 |
| p.A219P | LUAD | 1 |
| p.S227Y | HNSC | 1 |
| p.R658H | STAD | 1 |
| p.V224M | BRCA | 1 |
| p.G20E | SKCM | 1 |
| p.G742R | UCEC | 1 |
| p.M322I | LUAD | 1 |
| p.V265A | READ | 1 |
| p.A60V | COAD | 1 |
| p.G1007S | STAD | 1 |
| p.S382L | COAD | 1 |
| p.E691D | KIRC | 1 |
| p.V945I | LIHC | 1 |
| p.A180V | LUAD | 1 |
| p.G35E | PAAD | 1 |
| p.P606L | LIHC | 1 |
| p.A282T | READ | 1 |
| p.V584L | UCS | 1 |
| p.V101D | BLCA | 1 |
| p.A218V | UCEC | 1 |
| p.S227F | LUSC | 1 |
| p.T166P | SKCM | 1 |
| p.L372P | TGCT | 1 |
| p.K669T | BRCA | 1 |
| p.V1012I | COAD | 1 |
| p.A218V | UCS | 1 |
| p.C529* | HNSC | 1 |
| p.M332I | SKCM | 1 |
| p.E691Q | KIRC | 1 |
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| TissGeneCNV for ATP4A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ATP4A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A939-01A | ATP4A-FKBP4 | In-Frame | chr19:36049894 | chr12:2908253 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-A5-A1OH-01A | ZNF790-ATP4A | 5'UTR-CDS | chr19:37340903 | chr19:36044084 |
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| TissGeneNet for ATP4A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ATP4A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ATP4A |
| TissGeneDrug for ATP4A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00213 | Pantoprazole | Inhibitor | Small molecule | Approved |
| DB00448 | Lansoprazole | Inhibitor | Small molecule | Approved|Investigational |
| DB00736 | Esomeprazole | Inhibitor | Small molecule | Approved|Investigational |
| DB01129 | Rabeprazole | Inhibitor | Small molecule | Approved|Investigational |
| DB00338 | Omeprazole | Inhibitor | Small molecule | Approved|Investigational|Vet_approved |
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| TissGeneDisease for ATP4A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017168 | Gastroesophageal reflux disease | 21 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 21 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 19 | BeFree |
| umls:C0014457 | Eosinophilia | 6 | BeFree |
| umls:C1306759 | Eosinophilic disorder | 6 | BeFree |
| umls:C1636667 | Disorder characterized by eosinophilia | 6 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
| umls:C0029454 | Osteopetrosis | 4 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
| umls:C0030920 | Peptic Ulcer | 3 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 3 | BeFree |
| umls:C0004763 | Barrett Esophagus | 2 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
| umls:C0014869 | Peptic Esophagitis | 2 | BeFree |
| umls:C0026946 | Mycoses | 2 | BeFree |
| umls:C0038358 | Gastric ulcer | 2 | BeFree |
| umls:C0265292 | Schwartz-Lelek syndrome | 2 | BeFree |
| umls:C0333291 | Bleeding ulcer | 2 | BeFree |
| umls:C0343386 | Clostridium difficile infection | 2 | BeFree |
| umls:C0426576 | Gastrointestinal symptom | 2 | BeFree |
| umls:C0677659 | Gastro-esophageal reflux disease with esophagitis | 2 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 2 | BeFree |
| umls:C1318518 | Infantile malignant osteopetrosis | 2 | BeFree |
| umls:C1704380 | Distal Renal Tubular Acidosis | 2 | BeFree |
| umls:C0005940 | Bone Diseases | 1 | BeFree |
| umls:C0009782 | Connective Tissue Diseases | 1 | BeFree |
| umls:C0009806 | Constipation | 1 | BeFree |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0010414 | Infection by Cryptococcus neoformans | 1 | BeFree |
| umls:C0011991 | Diarrhea | 1 | BeFree |
| umls:C0013395 | Dyspepsia | 1 | BeFree |
| umls:C0014544 | Epilepsy | 1 | BeFree |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0017154 | Gastritis, Atrophic | 1 | BeFree |
| umls:C0017178 | Gastrointestinal Diseases | 1 | BeFree |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 1 | BeFree |
| umls:C0022681 | Medullary sponge kidney | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0153382 | Malignant neoplasm of oropharynx | 1 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
| umls:C0333294 | Recurrent ulcer | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0392514 | Hereditary hemochromatosis | 1 | BeFree |
| umls:C0452138 | Sensorineural hearing loss, bilateral | 1 | BeFree |
| umls:C0553694 | Oropharyngeal disorders | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | BeFree |
| umls:C1561921 | Non-ST elevation (NSTEMI) myocardial infarction | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2349952 | Oropharyngeal Carcinoma | 1 | BeFree |
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