TissGeneSummary for ODF2 |
Gene summary |
Basic gene information | Gene symbol | ODF2 |
Gene name | outer dense fiber of sperm tails 2 | |
Synonyms | CT134|ODF2/1|ODF2/2|ODF84 | |
Cytomap | UCSC genome browser: 9q34.11 | |
Type of gene | protein-coding | |
RefGenes | NM_001242352.1, NM_001242353.1,NM_001242354.1,NM_002540.4,NM_153432.1, NM_153433.1,NM_153435.1,NM_153436.1,NM_153437.2, NM_153439.1,NM_153440.1, | |
Description | cancer/testis antigen 134cenexin 1outer dense fiber of sperm tails, 84-kDouter dense fiber protein 2sperm tail structural protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 602015 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136811 | ||
HPRD : 03601 | ||
Vega : OTTHUMG00000020748 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ODF2 | |
BioGPS: 4957 | ||
Pathway | NCI Pathway Interaction Database: ODF2 | |
KEGG: ODF2 | ||
REACTOME: ODF2 | ||
Pathway Commons: ODF2 | ||
Context | iHOP: ODF2 | |
ligand binding site mutation search in PubMed: ODF2 | ||
UCL Cancer Institute: ODF2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ODF2 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ODF2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ODF2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ODF2 |
TissGeneSNV for ODF2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R887C | UCEC | 1 |
p.R746H | UCEC | 1 |
p.A869T | STAD | 1 |
p.R134W | UCEC | 1 |
p.E851K | STAD | 1 |
p.E418K | SKCM | 1 |
p.Q590H | SKCM | 1 |
p.M131I | HNSC | 1 |
p.K597T | SKCM | 1 |
p.M107I | HNSC | 1 |
p.E682Q | HNSC | 1 |
p.L579P | UCEC | 1 |
p.S377C | HNSC | 1 |
p.H132Y | LUAD | 1 |
p.A510V | UCEC | 1 |
p.D615Y | PAAD | 1 |
p.G209R | ESCA | 1 |
p.R509M | THYM | 1 |
p.R472H | ESCA | 1 |
p.L372P | KIRC | 1 |
p.E172K | COAD | 1 |
p.D591Y | PAAD | 1 |
p.L434I | BRCA | 1 |
p.N790H | LUAD | 1 |
p.P133S | SKCM | 1 |
p.E724Q | HNSC | 1 |
p.R4H | UCEC | 1 |
p.V600A | STAD | 1 |
p.L555F | SKCM | 1 |
p.R76L | LUAD | 1 |
p.V536A | STAD | 1 |
p.D488Y | BLCA | 1 |
p.Q680H | CHOL | 1 |
p.R437X | COAD | 1 |
p.P36H | STAD | 1 |
p.Y789X | COAD | 1 |
p.K202R | LIHC | 1 |
p.T774S | DLBC | 1 |
p.S58X | ESCA | 1 |
p.T24M | STAD | 1 |
p.P828H | PAAD | 1 |
p.R321W | COAD | 1 |
p.E588A | LIHC | 1 |
p.N442I | BRCA | 1 |
p.X894C | STAD | 1 |
p.A587V | UCEC | 1 |
p.A624V | UCEC | 1 |
p.D89G | HNSC | 1 |
p.P493S | SKCM | 1 |
p.R699K | SKCM | 1 |
p.S4L | LUAD | 1 |
p.P797R | READ | 1 |
p.Q125H | HNSC | 1 |
p.D679Y | PAAD | 1 |
p.T774S | PAAD | 1 |
p.E467K | SKCM | 1 |
p.H63Y | LUAD | 1 |
p.A79T | UCEC | 1 |
p.I670L | SKCM | 1 |
p.S6L | LUAD | 1 |
p.G541E | PAAD | 1 |
p.R799C | UCEC | 1 |
p.E658Q | HNSC | 1 |
p.E748Q | HNSC | 1 |
p.K548N | UCEC | 1 |
p.E335K | HNSC | 1 |
p.R554K | HNSC | 1 |
p.Q753K | LUAD | 1 |
p.E821G | LUSC | 1 |
p.R887H | DLBC | 1 |
p.L667R | CHOL | 1 |
p.P28L | SKCM | 1 |
p.E676A | LIHC | 1 |
p.A79T | READ | 1 |
p.R147H | COAD | 1 |
p.P797T | BRCA | 1 |
p.K548T | SKCM | 1 |
p.A805G | LUAD | 1 |
p.A829G | LUAD | 1 |
p.G517E | PAAD | 1 |
p.A268S | OV | 1 |
p.A351T | PAAD | 1 |
p.L664V | BLCA | 1 |
p.T68M | STAD | 1 |
p.L667P | UCEC | 1 |
p.L603Q | BLCA | 1 |
p.G605E | PAAD | 1 |
p.A415T | UCEC | 1 |
p.Q328R | BRCA | 1 |
p.K687T | CHOL | 1 |
p.L550F | SKCM | 1 |
p.S14L | BRCA | 1 |
p.K599T | CHOL | 1 |
p.D745N | COAD | 1 |
p.A109V | UCEC | 1 |
p.R530K | HNSC | 1 |
p.P57S | LUSC | 1 |
p.M551I | HNSC | 1 |
p.T169A | LUAD | 1 |
p.E787K | STAD | 1 |
p.S4L | BLCA | 1 |
p.E16K | CESC | 1 |
p.Q390R | KICH | 1 |
p.Q592H | CHOL | 1 |
p.N766H | LUAD | 1 |
p.W82* | STAD | 1 |
p.Q610H | COAD | 1 |
p.S401C | HNSC | 1 |
p.Q350H | LUAD | 1 |
p.M527I | HNSC | 1 |
p.P804H | PAAD | 1 |
p.Q326H | LUAD | 1 |
p.T582M | HNSC | 1 |
p.H87Y | LUAD | 1 |
p.R560H | ESCA | 1 |
p.D447Y | UCEC | 1 |
p.L284P | KIRC | 1 |
p.G297R | ESCA | 1 |
p.P542S | SKCM | 1 |
p.R338C | BRCA | 1 |
p.K118N | BRCA | 1 |
p.Q777K | LUAD | 1 |
p.E442D | COAD | 1 |
p.M202I | HNSC | 1 |
p.E676G | KIRC | 1 |
p.H231D | OV | 1 |
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TissGeneCNV for ODF2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ODF2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG990023 | ODF2-PLAT | chr9:131262529 | chr8:42033398 | |
Chimerdb3.0 | ChiTaRs | NA | BI012132 | ARFRP1-ODF2 | chr20:62338016 | chr9:131233661 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A0DS-01A | ODF2-SLC2A8 | NA | Chr9:131250304 | Chr9:130169715 |
TCGAfusionPortal | PRADA | OV | TCGA-61-1998-01A | GLE1-ODF2 | In-frame | Chr9:131267183 | Chr9:131254705 |
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TissGeneNet for ODF2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ODF2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ODF2 |
TissGeneDrug for ODF2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ODF2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |