TissGeneSummary for CLDN11 |
Gene summary |
Basic gene information | Gene symbol | CLDN11 |
Gene name | claudin 11 | |
Synonyms | OSP|OTM | |
Cytomap | UCSC genome browser: 3q26.2-q26.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001185056.1, NM_005602.5, | |
Description | claudin-11oligodendrocyte transmembrane proteinoligodendrocyte-specific protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 601326 | |
HGNC : HGNC | ||
HPRD : 03207 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CLDN11 | |
BioGPS: 5010 | ||
Pathway | NCI Pathway Interaction Database: CLDN11 | |
KEGG: CLDN11 | ||
REACTOME: CLDN11 | ||
Pathway Commons: CLDN11 | ||
Context | iHOP: CLDN11 | |
ligand binding site mutation search in PubMed: CLDN11 | ||
UCL Cancer Institute: CLDN11 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CLDN11 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CLDN11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.959330083 | 1.665061917 | -2.624392 | 2.77E-05 | 8.09E-05 |
LIHC | -1.162408083 | 0.305415917 | -1.467824 | 1.26E-05 | 5.18E-05 |
COAD | -1.532538237 | 0.982980993 | -2.515519231 | 5.75E-08 | 4.27E-07 |
HNSC | -1.51396999 | 0.867176521 | -2.381146512 | 2.03E-09 | 2.97E-08 |
BRCA | 0.674253531 | 3.816034232 | -3.141780702 | 9.96E-38 | 2.39E-36 |
LUAD | 0.042790675 | 2.030204468 | -1.987413793 | 2.17E-15 | 2.32E-14 |
KIRC | -1.268375417 | 1.762024583 | -3.0304 | 1.44E-23 | 1.52E-22 |
KIRP | -1.214876458 | 1.647223542 | -2.8621 | 1.49E-08 | 1.12E-07 |
BLCA | 0.13246318 | 2.244484232 | -2.112021053 | 0.000127 | 0.001332302 |
LUSC | 0.550271642 | 2.067355956 | -1.517084314 | 8.38E-05 | 0.000175225 |
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TissGene-miRNA for CLDN11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CLDN11 |
TissGeneSNV for CLDN11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S157F | SKCM | 2 |
p.R82H | LAML | 1 |
p.A88S | LUAD | 1 |
p.A145T | KIRP | 1 |
p.G113S | LGG | 1 |
p.V32M | SARC | 1 |
p.V16M | BRCA | 1 |
p.R107Q | LUAD | 1 |
p.S89* | LUAD | 1 |
p.P199S | SKCM | 1 |
p.G113V | LUAD | 1 |
p.A145T | LUSC | 1 |
p.G161D | BLCA | 1 |
p.A83T | STAD | 1 |
p.S198A | SKCM | 1 |
p.V152M | UCEC | 1 |
p.C168Y | HNSC | 1 |
p.R107W | KIRP | 1 |
p.S198F | SKCM | 1 |
p.M85I | SKCM | 1 |
p.R119Q | SKCM | 1 |
p.A134T | READ | 1 |
p.R189C | UCEC | 1 |
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TissGeneCNV for CLDN11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CLDN11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BP212615 | CLDN11-KCNMB4 | chr3:170141026 | chr12:70824368 | |
Chimerdb3.0 | ChiTaRs | NA | DA165167 | CLDN11-TSTD2 | chr3:170150395 | chr9:100364740 | |
Chimerdb3.0 | ChiTaRs | NA | DA211258 | CLDN11-AASDHPPT | chr3:170232821 | chr11:105955609 | |
Chimerdb3.0 | ChiTaRs | NA | AF068863 | CLDN11-NCAM2 | chr3:170150671 | chr21:22628643 | |
TCGAfusionPortal | PRADA | SKCM | TCGA-ER-A42H-01A | CMTM7-CLDN11 | Out-of-frame | Chr3:32433557 | Chr3:170425833 |
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TissGeneNet for CLDN11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CLDN11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CLDN11 |
TissGeneDrug for CLDN11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CLDN11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree,CTD_human |
umls:C0004936 | Mental disorders | 1 | GAD |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
umls:C0205748 | Dysplastic Nevus | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |