TissGeneSummary for DUOX2 |
Gene summary |
Basic gene information | Gene symbol | DUOX2 |
Gene name | dual oxidase 2 | |
Synonyms | LNOX2|NOXEF2|P138-TOX|TDH6|THOX2 | |
Cytomap | UCSC genome browser: 15q15.3 | |
Type of gene | protein-coding | |
RefGenes | NM_014080.4, | |
Description | NADH/NADPH thyroid oxidase p138-toxNADPH oxidase/peroxidase DUOX2NADPH thyroid oxidase 2dual oxidase-like domains 2flavoprotein NADPH oxidaselarge NOX 2long NOX 2nicotinamide adenine dinucleotide phosphate oxidasep138 thyroid oxidasethyroid oxida | |
Modification date | 20141207 | |
dbXrefs | MIM : 606759 | |
HGNC : HGNC | ||
Ensembl : ENSG00000140279 | ||
HPRD : 05997 | ||
Vega : OTTHUMG00000131355 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUOX2 | |
BioGPS: 50506 | ||
Pathway | NCI Pathway Interaction Database: DUOX2 | |
KEGG: DUOX2 | ||
REACTOME: DUOX2 | ||
Pathway Commons: DUOX2 | ||
Context | iHOP: DUOX2 | |
ligand binding site mutation search in PubMed: DUOX2 | ||
UCL Cancer Institute: DUOX2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADTHCA | |
Reference showing the relevant tissue of DUOX2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0009615 | response to virus | 16111680 | GO:0019221 | cytokine-mediated signaling pathway | 16111680 | GO:0051591 | response to cAMP | 15062544 | GO:0009615 | response to virus | 16111680 | GO:0019221 | cytokine-mediated signaling pathway | 16111680 | GO:0051591 | response to cAMP | 15062544 |
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TissGeneExp for DUOX2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -2.217250615 | -0.284263115 | -1.9329875 | 2.46E-05 | 9.58E-05 |
BRCA | -1.561711306 | -0.293518324 | -1.268192982 | 9.57E-11 | 3.77E-10 |
PRAD | 0.745147702 | 2.909101548 | -2.163953846 | 3.62E-07 | 2.87E-06 |
KIRC | -2.974665546 | -0.521540546 | -2.453125 | 2.39E-23 | 2.46E-22 |
LUAD | 0.844959837 | 2.464646044 | -1.619686207 | 4.13E-06 | 1.27E-05 |
HNSC | 4.184302219 | 5.321267335 | -1.136965116 | 0.0222 | 0.048779297 |
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TissGene-miRNA for DUOX2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DUOX2 |
TissGeneSNV for DUOX2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R536Q | SKCM | 2 |
p.S975F | SKCM | 2 |
p.P1519S | SKCM | 2 |
p.G912E | SKCM | 2 |
p.E657K | SKCM | 2 |
p.Q556* | STAD | 2 |
p.R1342H | UCEC | 2 |
p.Q556X | STAD | 2 |
p.R1084Q | SKCM | 2 |
p.Q631K | UCEC | 1 |
p.E1437K | SKCM | 1 |
p.I548V | PRAD | 1 |
p.Q1177H | LUSC | 1 |
p.V1055M | UCEC | 1 |
p.D870Y | UCEC | 1 |
p.V103I | LUAD | 1 |
p.L615F | SKCM | 1 |
p.E651K | BRCA | 1 |
p.E531D | LUAD | 1 |
p.V1090I | STAD | 1 |
p.S396F | SKCM | 1 |
p.T1086M | LGG | 1 |
p.E1438D | SKCM | 1 |
p.K1376N | COAD | 1 |
p.R1216W | COAD | 1 |
p.L479I | PRAD | 1 |
p.V1381L | THCA | 1 |
p.R625X | KIRC | 1 |
p.R56Q | BLCA | 1 |
p.S480C | LUSC | 1 |
p.N1166K | LUAD | 1 |
p.A1335T | STAD | 1 |
p.A643V | SKCM | 1 |
p.G418D | GBM | 1 |
p.R1461S | LUSC | 1 |
p.E1504Q | SKCM | 1 |
p.R1478Q | STAD | 1 |
p.A599V | TGCT | 1 |
p.V103I | STAD | 1 |
p.E902X | THYM | 1 |
p.Y65H | STAD | 1 |
p.V298A | COAD | 1 |
p.R969Q | GBM | 1 |
p.R625* | CESC | 1 |
p.F1498L | BLCA | 1 |
p.G854D | SKCM | 1 |
p.F508S | DLBC | 1 |
p.G944S | SKCM | 1 |
p.D1071V | HNSC | 1 |
p.R1478W | UCEC | 1 |
p.R523S | SARC | 1 |
p.M822K | LUAD | 1 |
p.M346L | HNSC | 1 |
p.Y1062H | SKCM | 1 |
p.P993L | SKCM | 1 |
p.S965L | SKCM | 1 |
p.F1034L | ESCA | 1 |
p.R1478W | SARC | 1 |
p.A1087V | STAD | 1 |
p.P689L | STAD | 1 |
p.L486F | SKCM | 1 |
p.R1538X | COAD | 1 |
p.R376W | READ | 1 |
p.L1243R | COAD | 1 |
p.A1146T | LIHC | 1 |
p.L555M | LGG | 1 |
p.A1134V | UCS | 1 |
p.I1417M | BLCA | 1 |
p.T1086M | STAD | 1 |
p.R1110* | HNSC | 1 |
p.S911L | ACC | 1 |
p.D424G | HNSC | 1 |
p.V1533I | GBM | 1 |
p.E810K | BLCA | 1 |
p.E723K | SKCM | 1 |
p.R1103H | UCEC | 1 |
p.P661L | STAD | 1 |
p.R861C | KICH | 1 |
p.K628* | LUSC | 1 |
p.K1457* | LUAD | 1 |
p.Y70C | PRAD | 1 |
p.R929Q | PAAD | 1 |
p.P453L | SKCM | 1 |
p.R50C | LUAD | 1 |
p.S350I | UCEC | 1 |
p.L31M | THYM | 1 |
p.A1146T | PRAD | 1 |
p.E1111* | UCEC | 1 |
p.F937Y | COAD | 1 |
p.S182N | BLCA | 1 |
p.K1511M | LUAD | 1 |
p.P557S | UCEC | 1 |
p.K635N | STAD | 1 |
p.A63P | PRAD | 1 |
p.W157* | SKCM | 1 |
p.S1349F | SKCM | 1 |
p.F1179L | COAD | 1 |
p.A1122V | STAD | 1 |
p.V685A | STAD | 1 |
p.M1464R | BRCA | 1 |
p.R625* | KIRC | 1 |
p.L1410M | LUAD | 1 |
p.G727D | LGG | 1 |
p.E1546D | UCEC | 1 |
p.V1274M | LUAD | 1 |
p.D534H | HNSC | 1 |
p.A1356T | HNSC | 1 |
p.D513Y | SARC | 1 |
p.P318S | SKCM | 1 |
p.V738M | UCEC | 1 |
p.E34K | SKCM | 1 |
p.M1409R | GBM | 1 |
p.R82P | LUAD | 1 |
p.W1374* | PRAD | 1 |
p.E713K | SKCM | 1 |
p.R1492C | STAD | 1 |
p.R909L | CHOL | 1 |
p.N1439I | LUAD | 1 |
p.R1128H | SKCM | 1 |
p.S1173F | SKCM | 1 |
p.A1014V | ESCA | 1 |
p.R625Q | LGG | 1 |
p.R1212H | UCEC | 1 |
p.S97T | HNSC | 1 |
p.R169W | COAD | 1 |
p.L438M | STAD | 1 |
p.G1365E | SKCM | 1 |
p.G488E | SKCM | 1 |
p.C1411Y | STAD | 1 |
p.R1021Q | SKCM | 1 |
p.G1352S | HNSC | 1 |
p.G1365E | LIHC | 1 |
p.R536Q | THYM | 1 |
p.T1482M | STAD | 1 |
p.G646R | SKCM | 1 |
p.Y373H | SKCM | 1 |
p.E1017G | DLBC | 1 |
p.E641* | CESC | 1 |
p.G991R | SKCM | 1 |
p.R764W | SKCM | 1 |
p.P584L | ESCA | 1 |
p.H111R | LIHC | 1 |
p.R625Q | DLBC | 1 |
p.R541W | STAD | 1 |
p.D1121N | SKCM | 1 |
p.P303R | UCEC | 1 |
p.K1528E | PCPG | 1 |
p.S876F | SKCM | 1 |
p.E902K | UCEC | 1 |
p.K709N | UCEC | 1 |
p.P1391S | LUAD | 1 |
p.R1334W | STAD | 1 |
p.G1189D | BLCA | 1 |
p.Q1408R | SKCM | 1 |
p.V387A | LIHC | 1 |
p.R56Q | COAD | 1 |
p.D141N | CESC | 1 |
p.G1406V | KIRC | 1 |
p.F1458L | BLCA | 1 |
p.H925Y | SKCM | 1 |
p.R766H | LGG | 1 |
p.R1211L | BLCA | 1 |
p.P134S | SKCM | 1 |
p.E1456D | UCEC | 1 |
p.R37L | ACC | 1 |
p.G948C | LUAD | 1 |
p.E533K | SKCM | 1 |
p.M650I | SKCM | 1 |
p.R536Q | COAD | 1 |
p.S1273C | LUAD | 1 |
p.P1350S | SKCM | 1 |
p.A502D | THYM | 1 |
p.R541L | SARC | 1 |
p.N173S | ACC | 1 |
p.H1332Q | LUAD | 1 |
p.N893S | SKCM | 1 |
p.F828L | ESCA | 1 |
p.S855F | SKCM | 1 |
p.D1459N | SKCM | 1 |
p.Q1288K | LIHC | 1 |
p.G488R | SKCM | 1 |
p.R1103C | COAD | 1 |
p.E751K | UCEC | 1 |
p.R739C | STAD | 1 |
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TissGeneCNV for DUOX2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DUOX2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF829816 | DUOX2-ERC2 | chr15:45385842 | chr3:55659483 | |
Chimerdb3.0 | ChiTaRs | NA | AA533569 | SDF2L1-DUOX2 | chr22:21998588 | chr15:45385646 | |
Chimerdb3.0 | ChiTaRs | NA | BG993206 | DUOX2-TAB2 | chr15:45386376 | chr6:149699821 |
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TissGeneNet for DUOX2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DUOX2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DUOX2 |
TissGeneDrug for DUOX2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DUOX2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010308 | Congenital Hypothyroidism | 22 | BeFree,CTD_human,LHGDN |
umls:C0342200 | Endemic Cretinism | 22 | BeFree |
umls:C0018203 | Chronic granulomatous disease | 8 | BeFree |
umls:C0020676 | Hypothyroidism | 6 | BeFree |
umls:C0018021 | Goiter | 4 | BeFree |
umls:C1846632 | Thyroid Dyshormonogenesis 6 | 3 | CLINVAR,CTD_human,MGD,UNIPROT |
umls:C0009324 | Ulcerative Colitis | 2 | BeFree |
umls:C0010346 | Crohn Disease | 2 | BeFree |
umls:C0018801 | Heart failure | 2 | BeFree |
umls:C0018802 | Congestive heart failure | 2 | BeFree |
umls:C0019693 | HIV Infections | 2 | BeFree,GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0009319 | Colitis | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0021400 | Influenza | 1 | BeFree |
umls:C0022116 | Ischemia | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0023860 | Listeriosis | 1 | BeFree |
umls:C0023890 | Liver Cirrhosis | 1 | GAD |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | BeFree,LHGDN |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0026946 | Mycoses | 1 | BeFree |
umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
umls:C0151650 | Renal fibrosis | 1 | BeFree |
umls:C0206682 | Follicular thyroid carcinoma | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0271790 | Subclinical hypothyroidism | 1 | BeFree |
umls:C0271826 | Iodide transport defect | 1 | BeFree |
umls:C0271829 | Pendred's syndrome | 1 | BeFree |
umls:C0349476 | Congenital goiter | 1 | BeFree |
umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
umls:C0600452 | Hepatopulmonary Syndrome | 1 | GAD |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C0751967 | Multiple Sclerosis, Relapsing-Remitting | 1 | BeFree |
umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
umls:C0917996 | Cerebral Aneurysm | 1 | BeFree |
umls:C0948008 | Ischemic stroke | 1 | BeFree |
umls:C1518296 | Neuropathogenesis | 1 | BeFree |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |