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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DUOX2
check button Gene summary
Basic gene informationGene symbolDUOX2
Gene namedual oxidase 2
SynonymsLNOX2|NOXEF2|P138-TOX|TDH6|THOX2
CytomapUCSC genome browser: 15q15.3
Type of geneprotein-coding
RefGenesNM_014080.4,
DescriptionNADH/NADPH thyroid oxidase p138-toxNADPH oxidase/peroxidase DUOX2NADPH thyroid oxidase 2dual oxidase-like domains 2flavoprotein NADPH oxidaselarge NOX 2long NOX 2nicotinamide adenine dinucleotide phosphate oxidasep138 thyroid oxidasethyroid oxida
Modification date20141207
dbXrefs MIM : 606759
HGNC : HGNC
Ensembl : ENSG00000140279
HPRD : 05997
Vega : OTTHUMG00000131355
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DUOX2
BioGPS: 50506
PathwayNCI Pathway Interaction Database: DUOX2
KEGG: DUOX2
REACTOME: DUOX2
Pathway Commons: DUOX2
ContextiHOP: DUOX2
ligand binding site mutation search in PubMed: DUOX2
UCL Cancer Institute: DUOX2
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonThyroid gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADTHCA
Reference showing the relevant tissue of DUOX2
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0009615response to virus16111680
GO:0019221cytokine-mediated signaling pathway16111680
GO:0051591response to cAMP15062544
GO:0009615response to virus16111680
GO:0019221cytokine-mediated signaling pathway16111680
GO:0051591response to cAMP15062544


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TissGeneExp for DUOX2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRP-2.217250615-0.284263115-1.93298752.46E-059.58E-05
BRCA-1.561711306-0.293518324-1.2681929829.57E-113.77E-10
PRAD0.7451477022.909101548-2.1639538463.62E-072.87E-06
KIRC-2.974665546-0.521540546-2.4531252.39E-232.46E-22
LUAD0.8449598372.464646044-1.6196862074.13E-061.27E-05
HNSC4.1843022195.321267335-1.1369651160.02220.048779297


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TissGene-miRNA for DUOX2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for DUOX2
TissGeneSNV for DUOX2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R536QSKCM2
p.S975FSKCM2
p.P1519SSKCM2
p.G912ESKCM2
p.E657KSKCM2
p.Q556*STAD2
p.R1342HUCEC2
p.Q556XSTAD2
p.R1084QSKCM2
p.Q631KUCEC1
p.E1437KSKCM1
p.I548VPRAD1
p.Q1177HLUSC1
p.V1055MUCEC1
p.D870YUCEC1
p.V103ILUAD1
p.L615FSKCM1
p.E651KBRCA1
p.E531DLUAD1
p.V1090ISTAD1
p.S396FSKCM1
p.T1086MLGG1
p.E1438DSKCM1
p.K1376NCOAD1
p.R1216WCOAD1
p.L479IPRAD1
p.V1381LTHCA1
p.R625XKIRC1
p.R56QBLCA1
p.S480CLUSC1
p.N1166KLUAD1
p.A1335TSTAD1
p.A643VSKCM1
p.G418DGBM1
p.R1461SLUSC1
p.E1504QSKCM1
p.R1478QSTAD1
p.A599VTGCT1
p.V103ISTAD1
p.E902XTHYM1
p.Y65HSTAD1
p.V298ACOAD1
p.R969QGBM1
p.R625*CESC1
p.F1498LBLCA1
p.G854DSKCM1
p.F508SDLBC1
p.G944SSKCM1
p.D1071VHNSC1
p.R1478WUCEC1
p.R523SSARC1
p.M822KLUAD1
p.M346LHNSC1
p.Y1062HSKCM1
p.P993LSKCM1
p.S965LSKCM1
p.F1034LESCA1
p.R1478WSARC1
p.A1087VSTAD1
p.P689LSTAD1
p.L486FSKCM1
p.R1538XCOAD1
p.R376WREAD1
p.L1243RCOAD1
p.A1146TLIHC1
p.L555MLGG1
p.A1134VUCS1
p.I1417MBLCA1
p.T1086MSTAD1
p.R1110*HNSC1
p.S911LACC1
p.D424GHNSC1
p.V1533IGBM1
p.E810KBLCA1
p.E723KSKCM1
p.R1103HUCEC1
p.P661LSTAD1
p.R861CKICH1
p.K628*LUSC1
p.K1457*LUAD1
p.Y70CPRAD1
p.R929QPAAD1
p.P453LSKCM1
p.R50CLUAD1
p.S350IUCEC1
p.L31MTHYM1
p.A1146TPRAD1
p.E1111*UCEC1
p.F937YCOAD1
p.S182NBLCA1
p.K1511MLUAD1
p.P557SUCEC1
p.K635NSTAD1
p.A63PPRAD1
p.W157*SKCM1
p.S1349FSKCM1
p.F1179LCOAD1
p.A1122VSTAD1
p.V685ASTAD1
p.M1464RBRCA1
p.R625*KIRC1
p.L1410MLUAD1
p.G727DLGG1
p.E1546DUCEC1
p.V1274MLUAD1
p.D534HHNSC1
p.A1356THNSC1
p.D513YSARC1
p.P318SSKCM1
p.V738MUCEC1
p.E34KSKCM1
p.M1409RGBM1
p.R82PLUAD1
p.W1374*PRAD1
p.E713KSKCM1
p.R1492CSTAD1
p.R909LCHOL1
p.N1439ILUAD1
p.R1128HSKCM1
p.S1173FSKCM1
p.A1014VESCA1
p.R625QLGG1
p.R1212HUCEC1
p.S97THNSC1
p.R169WCOAD1
p.L438MSTAD1
p.G1365ESKCM1
p.G488ESKCM1
p.C1411YSTAD1
p.R1021QSKCM1
p.G1352SHNSC1
p.G1365ELIHC1
p.R536QTHYM1
p.T1482MSTAD1
p.G646RSKCM1
p.Y373HSKCM1
p.E1017GDLBC1
p.E641*CESC1
p.G991RSKCM1
p.R764WSKCM1
p.P584LESCA1
p.H111RLIHC1
p.R625QDLBC1
p.R541WSTAD1
p.D1121NSKCM1
p.P303RUCEC1
p.K1528EPCPG1
p.S876FSKCM1
p.E902KUCEC1
p.K709NUCEC1
p.P1391SLUAD1
p.R1334WSTAD1
p.G1189DBLCA1
p.Q1408RSKCM1
p.V387ALIHC1
p.R56QCOAD1
p.D141NCESC1
p.G1406VKIRC1
p.F1458LBLCA1
p.H925YSKCM1
p.R766HLGG1
p.R1211LBLCA1
p.P134SSKCM1
p.E1456DUCEC1
p.R37LACC1
p.G948CLUAD1
p.E533KSKCM1
p.M650ISKCM1
p.R536QCOAD1
p.S1273CLUAD1
p.P1350SSKCM1
p.A502DTHYM1
p.R541LSARC1
p.N173SACC1
p.H1332QLUAD1
p.N893SSKCM1
p.F828LESCA1
p.S855FSKCM1
p.D1459NSKCM1
p.Q1288KLIHC1
p.G488RSKCM1
p.R1103CCOAD1
p.E751KUCEC1
p.R739CSTAD1


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TissGeneCNV for DUOX2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for DUOX2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABF829816DUOX2-ERC2chr15:45385842chr3:55659483
Chimerdb3.0ChiTaRsNAAA533569SDF2L1-DUOX2chr22:21998588chr15:45385646
Chimerdb3.0ChiTaRsNABG993206DUOX2-TAB2chr15:45386376chr6:149699821


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TissGeneNet for DUOX2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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COAD (tumor)COAD (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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HNSC (tumor)HNSC (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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KICH (tumor)KICH (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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KIRC (tumor)KIRC (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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KIRP (tumor)KIRP (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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LIHC (tumor)LIHC (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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LUAD (tumor)LUAD (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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LUSC (tumor)LUSC (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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PRAD (tumor)PRAD (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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STAD (tumor)STAD (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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THCA (tumor)THCA (normal)
DUOX2, NOD2, TXNDC11 (tumor)DUOX2, NOD2, TXNDC11 (normal)
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TissGeneProg for DUOX2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for DUOX2
TissGeneDrug for DUOX2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for DUOX2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0010308Congenital Hypothyroidism22BeFree,CTD_human,LHGDN
umls:C0342200Endemic Cretinism22BeFree
umls:C0018203Chronic granulomatous disease8BeFree
umls:C0020676Hypothyroidism6BeFree
umls:C0018021Goiter4BeFree
umls:C1846632Thyroid Dyshormonogenesis 63CLINVAR,CTD_human,MGD,UNIPROT
umls:C0009324Ulcerative Colitis2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0018801Heart failure2BeFree
umls:C0018802Congestive heart failure2BeFree
umls:C0019693HIV Infections2BeFree,GAD
umls:C0021390Inflammatory Bowel Diseases2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0009319Colitis1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0021400Influenza1BeFree
umls:C0022116Ischemia1BeFree
umls:C0023418leukemia1BeFree
umls:C0023860Listeriosis1BeFree
umls:C0023890Liver Cirrhosis1GAD
umls:C0024117Chronic Obstructive Airway Disease1BeFree,LHGDN
umls:C0024121Lung Neoplasms1LHGDN
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0026946Mycoses1BeFree
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0151650Renal fibrosis1BeFree
umls:C0206682Follicular thyroid carcinoma1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0271790Subclinical hypothyroidism1BeFree
umls:C0271826Iodide transport defect1BeFree
umls:C0271829Pendred's syndrome1BeFree
umls:C0349476Congenital goiter1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0600452Hepatopulmonary Syndrome1GAD
umls:C0684249Carcinoma of lung1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0751967Multiple Sclerosis, Relapsing-Remitting1BeFree
umls:C0856169Endothelial dysfunction1BeFree
umls:C0917996Cerebral Aneurysm1BeFree
umls:C0948008Ischemic stroke1BeFree
umls:C1518296Neuropathogenesis1BeFree
umls:C3272363Ischemic Cerebrovascular Accident1BeFree