TissGeneSummary for UBQLN3 |
Gene summary |
Basic gene information | Gene symbol | UBQLN3 |
Gene name | ubiquilin 3 | |
Synonyms | TUP-1 | |
Cytomap | UCSC genome browser: 11p15 | |
Type of gene | protein-coding | |
RefGenes | NM_017481.2, | |
Description | ubiquilin-3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605473 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175520 | ||
HPRD : 05684 | ||
Vega : OTTHUMG00000066886 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UBQLN3 | |
BioGPS: 50613 | ||
Pathway | NCI Pathway Interaction Database: UBQLN3 | |
KEGG: UBQLN3 | ||
REACTOME: UBQLN3 | ||
Pathway Commons: UBQLN3 | ||
Context | iHOP: UBQLN3 | |
ligand binding site mutation search in PubMed: UBQLN3 | ||
UCL Cancer Institute: UBQLN3 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of UBQLN3 | Ubqln3, a testis-specific gene, is dispensable for embryonic development and spermatogenesis in mice.Mol Reprod Dev. 2015 Apr;82(4):266-7. (pmid:25776854) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for UBQLN3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for UBQLN3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for UBQLN3 |
TissGeneSNV for UBQLN3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R624Q | COAD | 2 |
p.P469S | COAD | 1 |
p.P375Q | COAD | 1 |
p.D300H | CESC | 1 |
p.P108S | BRCA | 1 |
p.R225H | HNSC | 1 |
p.E399K | COAD | 1 |
p.S116L | SKCM | 1 |
p.R379K | SKCM | 1 |
p.T421N | TGCT | 1 |
p.P575S | SKCM | 1 |
p.N212S | STAD | 1 |
p.S113G | SKCM | 1 |
p.E232D | LUSC | 1 |
p.I247L | LUAD | 1 |
p.A268T | PAAD | 1 |
p.S51Y | UCEC | 1 |
p.R624Q | BRCA | 1 |
p.D450Y | BLCA | 1 |
p.D328Y | ESCA | 1 |
p.L140F | BLCA | 1 |
p.P277L | SKCM | 1 |
p.R484K | LUAD | 1 |
p.T641M | STAD | 1 |
p.T28K | LUAD | 1 |
p.R239P | LIHC | 1 |
p.P607H | STAD | 1 |
p.M598V | THCA | 1 |
p.L486P | COAD | 1 |
p.P472T | LUSC | 1 |
p.R454K | SKCM | 1 |
p.S113I | PAAD | 1 |
p.Y147C | THCA | 1 |
p.S585F | BLCA | 1 |
p.S463P | STAD | 1 |
p.S384L | SKCM | 1 |
p.S113G | STAD | 1 |
p.R631P | BLCA | 1 |
p.E613G | COAD | 1 |
p.G322W | LUAD | 1 |
p.P381S | SARC | 1 |
p.P442R | LUAD | 1 |
p.P277S | SKCM | 1 |
p.T109A | UCEC | 1 |
p.R53H | LUAD | 1 |
p.D450E | SKCM | 1 |
p.P277L | LUAD | 1 |
p.Q622K | COAD | 1 |
p.D443N | SKCM | 1 |
p.E351K | SKCM | 1 |
p.Y258C | LUSC | 1 |
p.E537* | UCEC | 1 |
p.L89Q | LUAD | 1 |
p.S370N | SKCM | 1 |
p.D59N | SKCM | 1 |
p.P474H | HNSC | 1 |
p.N492S | COAD | 1 |
p.L511F | LUSC | 1 |
p.P397S | SKCM | 1 |
p.E101K | LUAD | 1 |
p.R239L | LUSC | 1 |
p.T439I | OV | 1 |
p.R53C | LGG | 1 |
p.R218W | LIHC | 1 |
p.M626I | LUAD | 1 |
p.E537K | SKCM | 1 |
p.T109I | SKCM | 1 |
p.Q502K | PAAD | 1 |
p.M546I | LUSC | 1 |
p.D260N | SKCM | 1 |
p.P410L | SKCM | 1 |
p.N335H | STAD | 1 |
p.V445L | ESCA | 1 |
p.S106C | LUAD | 1 |
p.R487S | SKCM | 1 |
p.S355F | SKCM | 1 |
p.R540C | SKCM | 1 |
p.P58H | UCEC | 1 |
p.E33K | SKCM | 1 |
p.G357E | SKCM | 1 |
p.P375L | SKCM | 1 |
p.P381T | SKCM | 1 |
p.Q394K | LUAD | 1 |
p.Q17K | UCEC | 1 |
p.G589V | LUAD | 1 |
p.E245K | SKCM | 1 |
p.G627S | SKCM | 1 |
p.G250D | SKCM | 1 |
p.P353S | SKCM | 1 |
p.G318E | SKCM | 1 |
p.A268T | COAD | 1 |
p.E351K | READ | 1 |
p.P214L | SKCM | 1 |
p.S36T | LUAD | 1 |
p.P175S | SKCM | 1 |
p.P518S | SKCM | 1 |
p.F176S | ESCA | 1 |
p.L254I | ACC | 1 |
p.G115E | SKCM | 1 |
p.G627R | LUAD | 1 |
p.A430S | LUAD | 1 |
p.S387F | SKCM | 1 |
p.I261V | KICH | 1 |
p.P607S | SKCM | 1 |
p.K47M | LUAD | 1 |
p.F223L | STAD | 1 |
p.P472S | SKCM | 1 |
p.I177N | PAAD | 1 |
p.S12T | COAD | 1 |
p.N276T | STAD | 1 |
p.N335K | LUAD | 1 |
p.R218W | OV | 1 |
p.S383X | THYM | 1 |
p.P248L | SKCM | 1 |
p.S308T | GBM | 1 |
p.A268T | HNSC | 1 |
p.A614P | LIHC | 1 |
p.E351K | ESCA | 1 |
p.P547S | SKCM | 1 |
p.H615P | STAD | 1 |
p.I403L | BRCA | 1 |
p.A105V | UCEC | 1 |
p.P175T | KIRP | 1 |
p.626_627MG>IR | LUAD | 1 |
p.Q388* | LUAD | 1 |
p.H196Q | ESCA | 1 |
p.G275S | UCEC | 1 |
p.R631H | STAD | 1 |
p.S461Y | SKCM | 1 |
p.S236N | PAAD | 1 |
p.L211R | ESCA | 1 |
p.L591F | GBM | 1 |
p.C79Y | THCA | 1 |
p.A458D | UCEC | 1 |
p.S315I | STAD | 1 |
p.N574K | PRAD | 1 |
p.Q119E | HNSC | 1 |
p.D59N | UCEC | 1 |
p.G557E | SKCM | 1 |
p.S370N | HNSC | 1 |
p.G318R | SKCM | 1 |
p.P373L | SKCM | 1 |
p.P118H | HNSC | 1 |
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TissGeneCNV for UBQLN3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for UBQLN3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for UBQLN3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for UBQLN3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for UBQLN3 |
TissGeneDrug for UBQLN3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for UBQLN3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |