TissGeneSummary for CUZD1 |
Gene summary |
Basic gene information | Gene symbol | CUZD1 |
Gene name | CUB and zona pellucida-like domains 1 | |
Synonyms | ERG-1|UO-44 | |
Cytomap | UCSC genome browser: 10q26.13 | |
Type of gene | protein-coding | |
RefGenes | NM_022034.5, NR_037912.1, | |
Description | CUB and ZP domain-containing protein 1CUB and zona pellucida-like domain-containing protein 1estrogen regulated gene 1transmembrane protein UO-44 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000138161 | ||
HPRD : 06476 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CUZD1 | |
BioGPS: 50624 | ||
Pathway | NCI Pathway Interaction Database: CUZD1 | |
KEGG: CUZD1 | ||
REACTOME: CUZD1 | ||
Pathway Commons: CUZD1 | ||
Context | iHOP: CUZD1 | |
ligand binding site mutation search in PubMed: CUZD1 | ||
UCL Cancer Institute: CUZD1 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of CUZD1 | Diagnostic and clinical significance of Crohn's disease-specific pancreatic anti-GP2 and anti-CUZD1 antibodies. Pavlidis P, Komorowski L, Teegen B, Liaskos C, Koutsoumpas AL, Smyk DS, Perricone C, Mytilinaiou MG, Stocker W, Forbes A, Bogdanos DP. Clin Chem Lab Med. 2016 Feb;54(2):249-56. doi: 10.1515/cclm-2015-0376. (pmid:26351932) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CUZD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CUZD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CUZD1 |
TissGeneSNV for CUZD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D250N | SKCM | 2 |
p.E351K | SKCM | 2 |
p.P114S | SKCM | 2 |
p.S75F | SKCM | 2 |
p.D111N | LUAD | 1 |
p.Q358* | BLCA | 1 |
p.S545N | SKCM | 1 |
p.P565H | PAAD | 1 |
p.D305N | LUAD | 1 |
p.S16F | LIHC | 1 |
p.K407N | UCS | 1 |
p.R231C | STAD | 1 |
p.K288R | UCEC | 1 |
p.S347F | SKCM | 1 |
p.E237X | PAAD | 1 |
p.L322P | SKCM | 1 |
p.R64K | SARC | 1 |
p.E559G | SKCM | 1 |
p.D210N | SKCM | 1 |
p.R596W | SKCM | 1 |
p.D189H | CESC | 1 |
p.S167R | SARC | 1 |
p.L247F | MESO | 1 |
p.E292Q | LUAD | 1 |
p.C107X | COAD | 1 |
p.R544* | CESC | 1 |
p.R539C | SKCM | 1 |
p.S240L | SKCM | 1 |
p.Q605K | THYM | 1 |
p.I192V | READ | 1 |
p.V589G | SKCM | 1 |
p.R511C | SKCM | 1 |
p.S493Y | READ | 1 |
p.S164F | SKCM | 1 |
p.E237K | LUAD | 1 |
p.E198K | SKCM | 1 |
p.D204N | HNSC | 1 |
p.V34F | SKCM | 1 |
p.Y255N | SKCM | 1 |
p.Q595* | SKCM | 1 |
p.S573F | SKCM | 1 |
p.I286M | SKCM | 1 |
p.F318C | UCEC | 1 |
p.R464Q | KIRC | 1 |
p.R136I | UCEC | 1 |
p.M48I | OV | 1 |
p.E292* | LUAD | 1 |
p.R355H | KIRC | 1 |
p.E56V | STAD | 1 |
p.S259F | UCEC | 1 |
p.A19T | LUSC | 1 |
p.D82N | SKCM | 1 |
p.A398T | PAAD | 1 |
p.R329K | SKCM | 1 |
p.G368E | SKCM | 1 |
p.I72S | UCEC | 1 |
p.D82N | HNSC | 1 |
p.I458S | READ | 1 |
p.S120F | SKCM | 1 |
p.I90S | COAD | 1 |
p.N394I | STAD | 1 |
p.G226E | SKCM | 1 |
p.V34G | SKCM | 1 |
p.N221S | SKCM | 1 |
p.R355H | ESCA | 1 |
p.L15I | UCEC | 1 |
p.A398V | COAD | 1 |
p.Y255H | SKCM | 1 |
p.K172N | LUSC | 1 |
p.I265M | COAD | 1 |
p.L312S | LIHC | 1 |
p.Q481* | LUAD | 1 |
p.R355G | BLCA | 1 |
p.S35N | SKCM | 1 |
p.W529* | BRCA | 1 |
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TissGeneCNV for CUZD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CUZD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF851732 | CUZD1-PACS1 | chr10:124613051 | chr11:65885385 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A04U-01A | TIAL1-CUZD1 | CDS-5UTR | Chr10:121355946 | Chr10:124605736 |
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TissGeneNet for CUZD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CUZD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CUZD1 |
TissGeneDrug for CUZD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CUZD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
umls:C0010346 | Crohn Disease | 1 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |