TissGeneSummary for KCNK4 |
Gene summary |
Basic gene information | Gene symbol | KCNK4 |
Gene name | potassium channel, subfamily K, member 4 | |
Synonyms | K2p4.1|TRAAK|TRAAK1 | |
Cytomap | UCSC genome browser: 11q13 | |
Type of gene | protein-coding | |
RefGenes | NM_033310.2, NM_016611.2,NM_033311.1, | |
Description | K2P4.1 potassium channelTWIK-related arachidonic acid-stimulated potassium channel proteinpotassium channel subfamily K member 4two pore K(+) channel KT4.1two pore K+ channel KT4.1two pore potassium channel KT4.1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605720 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182450 | ||
HPRD : 12037 | ||
Vega : OTTHUMG00000168006 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNK4 | |
BioGPS: 50801 | ||
Pathway | NCI Pathway Interaction Database: KCNK4 | |
KEGG: KCNK4 | ||
REACTOME: KCNK4 | ||
Pathway Commons: KCNK4 | ||
Context | iHOP: KCNK4 | |
ligand binding site mutation search in PubMed: KCNK4 | ||
UCL Cancer Institute: KCNK4 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGTGCT | |
Reference showing the relevant tissue of KCNK4 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNK4 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.342190514 | -0.34126848 | -1.000922034 | 6.91E-07 | 2.67E-06 |
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TissGene-miRNA for KCNK4 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNK4 |
TissGeneSNV for KCNK4 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V138F | SARC | 1 |
p.G149D | SKCM | 1 |
p.R147H | STAD | 1 |
p.S72L | BLCA | 1 |
p.R126W | PRAD | 1 |
p.F157L | READ | 1 |
p.Q20* | BLCA | 1 |
p.T209M | UCEC | 1 |
p.A188V | STAD | 1 |
p.R13Q | PRAD | 1 |
p.R385C | SKCM | 1 |
p.V235M | COAD | 1 |
p.R366T | HNSC | 1 |
p.R141Q | PAAD | 1 |
p.Q20* | CESC | 1 |
p.S55Y | BLCA | 1 |
p.E57G | LIHC | 1 |
p.E250A | BLCA | 1 |
p.D55N | ESCA | 1 |
p.A247T | LUSC | 1 |
p.H217D | BLCA | 1 |
p.R117C | BRCA | 1 |
p.P328L | COAD | 1 |
p.C120R | COAD | 1 |
p.A14V | UCEC | 1 |
p.G61E | SKCM | 1 |
p.L47M | LIHC | 1 |
p.A68D | LUAD | 1 |
p.G291W | LUAD | 1 |
p.N108K | BRCA | 1 |
p.E195K | HNSC | 1 |
p.P228S | HNSC | 1 |
p.A326D | HNSC | 1 |
p.G222R | SKCM | 1 |
p.S351W | BLCA | 1 |
p.P221T | HNSC | 1 |
p.G315D | STAD | 1 |
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TissGeneCNV for KCNK4 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNK4 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KCNK4 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNK4 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNK4 |
TissGeneDrug for KCNK4 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNK4 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |