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| TissGeneSummary for IPO11 |
 Gene summary |
| Basic gene information | Gene symbol | IPO11 |
| Gene name | importin 11 | |
| Synonyms | RanBP11 | |
| Cytomap | UCSC genome browser: 5q12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001134779.1, NM_016338.4, | |
| Description | Ran binding protein 11imp11importin-11ran-binding protein 11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610889 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000086200 | ||
| HPRD : 10003 | ||
| HPRD : 18066 | ||
| Vega : OTTHUMG00000154400 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IPO11 | |
| BioGPS: 51194 | ||
| Pathway | NCI Pathway Interaction Database: IPO11 | |
| KEGG: IPO11 | ||
| REACTOME: IPO11 | ||
| Pathway Commons: IPO11 | ||
| Context | iHOP: IPO11 | |
| ligand binding site mutation search in PubMed: IPO11 | ||
| UCL Cancer Institute: IPO11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTGCT | |
| Reference showing the relevant tissue of IPO11 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for IPO11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for IPO11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UVM | hsa-miR-532-3p | MIMAT0004780 | 0.015 | -0.27 | 80 |
| LUSC | hsa-let-7c-5p | MIMAT0000064 | 0.0017 | -0.28 | 128 |
| ACC | hsa-miR-7-5p | MIMAT0000252 | 0.0065 | -0.31 | 78 |
| ACC | hsa-miR-7-5p | MIMAT0000252 | 0.0065 | -0.31 | 78 |
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| TissGeneMut for IPO11 |
| TissGeneSNV for IPO11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q606* | LUSC | 1 |
| p.I688V | ESCA | 1 |
| p.L188F | CHOL | 1 |
| p.L168V | READ | 1 |
| p.R131C | COAD | 1 |
| p.L641M | STAD | 1 |
| p.R116H | UCEC | 1 |
| p.N300D | COAD | 1 |
| p.S255N | TGCT | 1 |
| p.P520R | CESC | 1 |
| p.T358P | ACC | 1 |
| p.R143* | STAD | 1 |
| p.D455H | LUSC | 1 |
| p.Q293E | BLCA | 1 |
| p.F220C | STAD | 1 |
| p.W543C | UCEC | 1 |
| p.S7I | UCS | 1 |
| p.R494H | STAD | 1 |
| p.L148F | CHOL | 1 |
| p.S83L | HNSC | 1 |
| p.G257C | STAD | 1 |
| p.P360S | HNSC | 1 |
| p.L203R | STAD | 1 |
| p.S295N | TGCT | 1 |
| p.H700P | COAD | 1 |
| p.V787M | LUAD | 1 |
| p.P679S | SKCM | 1 |
| p.K208T | UCEC | 1 |
| p.R143* | HNSC | 1 |
| p.F356L | HNSC | 1 |
| p.E126K | SKCM | 1 |
| p.V643I | SKCM | 1 |
| p.F180C | STAD | 1 |
| p.R183X | STAD | 1 |
| p.E340A | KIRC | 1 |
| p.R91L | SKCM | 1 |
| p.K402E | READ | 1 |
| p.S43L | BLCA | 1 |
| p.S287L | SKCM | 1 |
| p.Q632* | BLCA | 1 |
| p.E589Q | BLCA | 1 |
| p.E521X | READ | 1 |
| p.S214L | SKCM | 1 |
| p.H458Y | LUSC | 1 |
| p.Y359* | SKCM | 1 |
| p.N751S | THCA | 1 |
| p.F49L | KIRC | 1 |
| p.R210* | STAD | 1 |
| p.P360L | SKCM | 1 |
| p.T398P | ACC | 1 |
| p.D568Y | UCEC | 1 |
| p.I332V | LUSC | 1 |
| p.N711S | THCA | 1 |
| p.E86K | SKCM | 1 |
| p.G40C | LUAD | 1 |
| p.P360S | SKCM | 1 |
| p.C360F | LUSC | 1 |
| p.A221V | READ | 1 |
| p.R250X | STAD | 1 |
| p.I728V | ESCA | 1 |
| p.P130S | SKCM | 1 |
| p.A983T | UCEC | 1 |
| p.G390D | SKCM | 1 |
| p.V603I | SKCM | 1 |
| p.R250L | THYM | 1 |
| p.S371C | HNSC | 1 |
| p.G781R | HNSC | 1 |
| p.E380A | KIRC | 1 |
| p.L988P | LUSC | 1 |
| p.S327L | SKCM | 1 |
| p.S874L | BLCA | 1 |
| p.S254L | SKCM | 1 |
| p.M618V | LIHC | 1 |
| p.P400L | SKCM | 1 |
| p.S47I | UCS | 1 |
| p.L608R | LUSC | 1 |
| p.E793Q | COAD | 1 |
| p.L163R | STAD | 1 |
| p.D471G | LGG | 1 |
| p.N264H | UCEC | 1 |
| p.E986K | LUSC | 1 |
| p.R533X | COAD | 1 |
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| TissGeneCNV for IPO11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for IPO11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW750241 | C5orf28-IPO11 | chr5:43480466 | chr5:61754084 | |
| Chimerdb3.0 | ChiTaRs | NA | BU507077 | IPO11-RFFL | chr5:61836556 | chr17:33336895 | |
| Chimerdb3.0 | ChiTaRs | NA | CB155026 | IPO11-SAP30BP | chr5:61819528 | chr17:73663450 | |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-LL-A73Y-01A | KIF2A-IPO11 | In-Frame | chr5:61643994 | chr5:61733100 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A08L-01A | IPO11-TNFAIP8 | In-frame | Chr5:61770291 | Chr5:118728511 |
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| TissGeneNet for IPO11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| COAD (tumor) | COAD (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| KICH (tumor) | KICH (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| STAD (tumor) | STAD (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| THCA (tumor) | THCA (normal) |
| IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (tumor) | IPO11, MYC, UBE2E3, TRAF2, PHLDA3, UBE2E1, PTP4A3, KEAP1, RAN, UBE2E2, ARF6, C20orf24, DDX5, RPL12, NXF1, PLCD4 (normal) |
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| TissGeneProg for IPO11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for IPO11 |
| TissGeneDrug for IPO11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for IPO11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0043094 | Weight Gain | 1 | CTD_human |
| umls:C0086025 | Codependency | 1 | BeFree |
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