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| TissGeneSummary for CLDN18 |
 Gene summary |
| Basic gene information | Gene symbol | CLDN18 |
| Gene name | claudin 18 | |
| Synonyms | SFTA5|SFTPJ | |
| Cytomap | UCSC genome browser: 3q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001002026.2, NM_016369.3, | |
| Description | claudin-18surfactant associated 5surfactant associated protein Jsurfactant, pulmonary associated protein J | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609210 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000066405 | ||
| HPRD : 13066 | ||
| Vega : OTTHUMG00000159762 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLDN18 | |
| BioGPS: 51208 | ||
| Pathway | NCI Pathway Interaction Database: CLDN18 | |
| KEGG: CLDN18 | ||
| REACTOME: CLDN18 | ||
| Pathway Commons: CLDN18 | ||
| Context | iHOP: CLDN18 | |
| ligand binding site mutation search in PubMed: CLDN18 | ||
| UCL Cancer Institute: CLDN18 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
| Reference showing the relevant tissue of CLDN18 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CLDN18 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.596672473 | -0.993584473 | -1.603088 | 2.55E-11 | 2.24E-10 |
| LUSC | 2.427772155 | 11.02307608 | -8.595303922 | 5.88E-26 | 1.44E-24 |
| LUAD | 4.678719044 | 11.3817518 | -6.703032759 | 5.80E-20 | 1.17E-18 |
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| TissGene-miRNA for CLDN18 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CLDN18 |
| TissGeneSNV for CLDN18 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V177A | LIHC | 1 |
| p.R55Q | HNSC | 1 |
| p.Y66* | ESCA | 1 |
| p.M27I | SKCM | 1 |
| p.V162G | THYM | 1 |
| p.M83V | SKCM | 1 |
| p.L130I | COAD | 1 |
| p.S210Y | UCEC | 1 |
| p.V3M | CESC | 1 |
| p.N116I | KIRP | 1 |
| p.V40I | BLCA | 1 |
| p.R80X | STAD | 1 |
| p.R168K | SKCM | 1 |
| p.Y66X | ESCA | 1 |
| p.A24T | SKCM | 1 |
| p.A23T | STAD | 1 |
| p.R80* | STAD | 1 |
| p.L143M | UCEC | 1 |
| p.M191I | COAD | 1 |
| p.Q56H | BLCA | 1 |
| p.W30G | SKCM | 1 |
| p.M27I | READ | 1 |
| p.R105H | LUAD | 1 |
| p.E250K | SKCM | 1 |
| p.G8S | SKCM | 1 |
| p.S14L | CESC | 1 |
| p.R80Q | SKCM | 1 |
| p.A227T | STAD | 1 |
| p.A2V | SKCM | 1 |
| p.S14L | LUAD | 1 |
| p.A134V | COAD | 1 |
| p.D34N | LUAD | 1 |
| p.G71R | SKCM | 1 |
| p.R55Q | GBM | 1 |
| p.H258Q | UCEC | 1 |
| p.D242N | HNSC | 1 |
| p.T5A | UCEC | 1 |
| p.F11L | SKCM | 1 |
| p.D259N | SKCM | 1 |
| p.A19G | LUAD | 1 |
| p.Y46* | OV | 1 |
| p.C131G | UCEC | 1 |
| p.A213T | UCEC | 1 |
| p.V13G | LUSC | 1 |
| p.R51K | SKCM | 1 |
| p.E250D | HNSC | 1 |
| p.F67V | UCEC | 1 |
| p.L9F | KIRC | 1 |
| p.V88F | LAML | 1 |
| p.G59C | KIRC | 1 |
| p.V40I | LUAD | 1 |
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| TissGeneCNV for CLDN18 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CLDN18 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BM854674 | CLDN18-UACA | chr3:137752491 | chr15:71043414 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0CL-01A | PLS1-CLDN18 | 5UTR-CDS | Chr3:142315351 | Chr3:137742500 |
| TCGAfusionPortal | PRADA | LGG | TCGA-E1-5303-01A | ARMC8-CLDN18 | 5UTR-CDS | Chr3:137906441 | Chr3:137742500 |
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| TissGeneNet for CLDN18 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| COAD (tumor) | COAD (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| KICH (tumor) | KICH (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| STAD (tumor) | STAD (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| THCA (tumor) | THCA (normal) |
| CLDN18, CLDN19 (tumor) | CLDN18, CLDN19 (normal) |
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| TissGeneProg for CLDN18 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CLDN18 |
| TissGeneDrug for CLDN18 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CLDN18 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0699791 | Stomach Carcinoma | 9 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 8 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree,LHGDN |
| umls:C0006287 | Bronchopulmonary Dysplasia | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009319 | Colitis | 1 | BeFree,LHGDN |
| umls:C0009324 | Ulcerative Colitis | 1 | BeFree |
| umls:C0017154 | Gastritis, Atrophic | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0149826 | Gastric adenoma | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0206696 | Carcinoma, Signet Ring Cell | 1 | LHGDN |
| umls:C0206704 | Carcinoma, Large Cell | 1 | BeFree |
| umls:C0349530 | Early gastric cancer | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1176475 | Ductal Carcinoma | 1 | BeFree |
| umls:C1301034 | Pancreatic intraepithelial neoplasia | 1 | BeFree |
| umls:C1368683 | Epithelioma | 1 | BeFree |
| umls:C1527349 | Ductal Breast Carcinoma | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
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