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| TissGeneSummary for CDKL3 |
 Gene summary |
| Basic gene information | Gene symbol | CDKL3 |
| Gene name | cyclin-dependent kinase-like 3 | |
| Synonyms | NKIAMRE | |
| Cytomap | UCSC genome browser: 5q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001113575.1, NM_001300853.1,NM_016508.3, | |
| Description | serine-threonine protein kinase NKIAMREserine/threonine-protein kinase NKIAMRE | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608459 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000006837 | ||
| Vega : OTTHUMG00000186341 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CDKL3 | |
| BioGPS: 51265 | ||
| Pathway | NCI Pathway Interaction Database: CDKL3 | |
| KEGG: CDKL3 | ||
| REACTOME: CDKL3 | ||
| Pathway Commons: CDKL3 | ||
| Context | iHOP: CDKL3 | |
| ligand binding site mutation search in PubMed: CDKL3 | ||
| UCL Cancer Institute: CDKL3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of CDKL3 | ||
| Description by TissGene annotations | Cancer gene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CDKL3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 0.019711207 | 1.378775207 | -1.359064 | 8.58E-08 | 3.97E-07 |
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| TissGene-miRNA for CDKL3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CDKL3 |
| TissGeneSNV for CDKL3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E50* | UCEC | 2 |
| p.T402I | SKCM | 1 |
| p.R464L | LUAD | 1 |
| p.D279G | PCPG | 1 |
| p.R268H | UCEC | 1 |
| p.R110H | STAD | 1 |
| p.E507Q | BLCA | 1 |
| p.Q42* | HNSC | 1 |
| p.X593Q | STAD | 1 |
| p.R395Q | STAD | 1 |
| p.P405T | ESCA | 1 |
| p.R586I | UCEC | 1 |
| p.D83N | BRCA | 1 |
| p.A301V | PAAD | 1 |
| p.T163I | COAD | 1 |
| p.P297L | CESC | 1 |
| p.G8R | LUAD | 1 |
| p.R111* | UCEC | 1 |
| p.R49* | OV | 1 |
| p.L209F | SKCM | 1 |
| p.R325W | LIHC | 1 |
| p.W165* | BLCA | 1 |
| p.C579Y | PRAD | 1 |
| p.M394V | STAD | 1 |
| p.Y105D | KIRP | 1 |
| p.L449F | UCEC | 1 |
| p.E317Q | SKCM | 1 |
| p.P373T | THYM | 1 |
| p.L210I | UCEC | 1 |
| p.V565A | LUSC | 1 |
| p.R497Q | UCEC | 1 |
| p.K24N | UCEC | 1 |
| p.P373S | SKCM | 1 |
| p.K33R | HNSC | 1 |
| p.R111X | READ | 1 |
| p.V10L | LUAD | 1 |
| p.R464C | UCEC | 1 |
| p.K362N | UCEC | 1 |
| p.G417C | STAD | 1 |
| p.P202S | SKCM | 1 |
| p.R101Q | STAD | 1 |
| p.L7I | SARC | 1 |
| p.H117P | COAD | 1 |
| p.L110I | STAD | 1 |
| p.S177C | BLCA | 1 |
| p.S205C | SKCM | 1 |
| p.K552N | UCEC | 1 |
| p.K352N | BRCA | 1 |
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| TissGeneCNV for CDKL3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CDKL3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LGG | TCGA-TQ-A7RI-01A | CDKL3-PPP2CA | In-Frame | chr5:133638280 | chr5:133541822 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-S9-A7R4-01A | CDKL3-PPP2CA | In-Frame | chr5:133638280 | chr5:133541822 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JD-01A | CDKL3-PPP2CA | In-Frame | chr5:133638280 | chr5:133541822 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | Out-of-Frame | chr5:133561450 | chr5:133642393 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | In-Frame | chr5:133561450 | chr5:133640258 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | In-Frame | chr5:133561450 | chr5:133644157 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | Out-of-Frame | chr5:133561450 | chr5:133644418 |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-05-4427-01A | CDH1-CDKL3 | Out-of-Frame | chr16:68856128 | chr5:133644157 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | In-Frame | chr5:133561450 | chr5:133640257 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | Out-of-Frame | chr5:133561450 | chr5:133642392 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | In-Frame | chr5:133561450 | chr5:133644156 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | Out-of-Frame | chr5:133561450 | chr5:133644417 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A0JD-01A | PPP2CA-CDKL3 | In-frame | Chr5:133561451 | Chr5:133640258 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4427-01A | CDH1-CDKL3 | Out-of-frame | Chr16:68856128 | Chr5:133644157 |
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| TissGeneNet for CDKL3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| COAD (tumor) | COAD (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| KICH (tumor) | KICH (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| STAD (tumor) | STAD (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| THCA (tumor) | THCA (normal) |
| CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (tumor) | CDKL3, GGA1, HNF4A, SNRNP70, TTF2 (normal) |
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| TissGeneProg for CDKL3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CDKL3 |
| TissGeneDrug for CDKL3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CDKL3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C3714756 | Intellectual Disability | 1 | LHGDN |
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