TissGeneSummary for CEND1 |
Gene summary |
Basic gene information | Gene symbol | CEND1 |
Gene name | cell cycle exit and neuronal differentiation 1 | |
Synonyms | BM88 | |
Cytomap | UCSC genome browser: 11p15.5 | |
Type of gene | protein-coding | |
RefGenes | NM_016564.3, | |
Description | BM88 antigencell cycle exit and neuronal differentiation protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608213 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184524 | ||
HPRD : 16300 | ||
Vega : OTTHUMG00000133308 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CEND1 | |
BioGPS: 51286 | ||
Pathway | NCI Pathway Interaction Database: CEND1 | |
KEGG: CEND1 | ||
REACTOME: CEND1 | ||
Pathway Commons: CEND1 | ||
Context | iHOP: CEND1 | |
ligand binding site mutation search in PubMed: CEND1 | ||
UCL Cancer Institute: CEND1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of CEND1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CEND1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | 1.526913952 | 3.092819721 | -1.565905769 | 3.76E-10 | 6.85E-09 |
KIRP | -0.58768052 | 1.65247573 | -2.24015625 | 1.01E-07 | 6.07E-07 |
LIHC | -0.552061895 | -2.036333895 | 1.484272 | 7.25E-08 | 5.26E-07 |
KICH | 5.873130105 | 1.798238105 | 4.074892 | 3.58E-10 | 2.53E-09 |
KIRC | -0.915306561 | 1.061712883 | -1.977019444 | 4.11E-17 | 2.44E-16 |
COAD | -0.550809125 | 1.568383182 | -2.119192308 | 1.44E-08 | 1.24E-07 |
STAD | 0.402928855 | 1.57490698 | -1.171978125 | 0.00211 | 0.00949078 |
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TissGene-miRNA for CEND1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CEND1 |
TissGeneSNV for CEND1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P51S | STAD | 1 |
p.D31N | CESC | 1 |
p.E23Q | BLCA | 1 |
p.G100R | BLCA | 1 |
p.L78M | UCEC | 1 |
p.G112E | SKCM | 1 |
p.S76I | STAD | 1 |
p.S40L | BLCA | 1 |
p.P11T | LUAD | 1 |
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TissGeneCNV for CEND1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CEND1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CEND1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CEND1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CEND1 |
TissGeneDrug for CEND1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CEND1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004903 | Beckwith-Wiedemann Syndrome | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0424605 | Developmental delay (disorder) | 1 | BeFree |
umls:C0431399 | Familial aplasia of the vermis | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |