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| TissGeneSummary for PLA1A |
 Gene summary |
| Basic gene information | Gene symbol | PLA1A |
| Gene name | phospholipase A1 member A | |
| Synonyms | PS-PLA1|PSPLA1 | |
| Cytomap | UCSC genome browser: 3q13.13-q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001206960.1, NM_001206961.1,NM_015900.3,NM_001293225.1,NR_120610.1, | |
| Description | phosphatidylserine-specific phospholipase A1alpha | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607460 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144837 | ||
| HPRD : 07078 | ||
| Vega : OTTHUMG00000159425 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLA1A | |
| BioGPS: 51365 | ||
| Pathway | NCI Pathway Interaction Database: PLA1A | |
| KEGG: PLA1A | ||
| REACTOME: PLA1A | ||
| Pathway Commons: PLA1A | ||
| Context | iHOP: PLA1A | |
| ligand binding site mutation search in PubMed: PLA1A | ||
| UCL Cancer Institute: PLA1A | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungSkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSKCM | |
| Reference showing the relevant tissue of PLA1A | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PLA1A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 4.548655954 | 3.093005954 | 1.45565 | 5.22E-17 | 3.08E-16 |
| LUSC | 0.013431199 | 3.251513552 | -3.238082353 | 3.38E-17 | 2.74E-16 |
| LUAD | 1.161801787 | 3.051596615 | -1.889794828 | 2.43E-15 | 2.57E-14 |
| HNSC | -1.16726798 | -0.096909841 | -1.07035814 | 0.00161 | 0.005152916 |
| PRAD | 4.328788325 | 2.995709479 | 1.333078846 | 0.000502 | 0.001764042 |
| KIRP | 4.186095537 | 2.857445537 | 1.32865 | 0.000477 | 0.001412727 |
| STAD | 1.941186162 | 0.101829912 | 1.83935625 | 6.71E-05 | 0.000552776 |
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| TissGene-miRNA for PLA1A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PLA1A |
| TissGeneSNV for PLA1A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S448F | SKCM | 2 |
| p.P281S | SKCM | 2 |
| p.S284N | DLBC | 1 |
| p.H87Y | SKCM | 1 |
| p.D241G | LIHC | 1 |
| p.G230R | SKCM | 1 |
| p.G238R | UCEC | 1 |
| p.L55I | UCEC | 1 |
| p.V93F | HNSC | 1 |
| p.G180V | LGG | 1 |
| p.F212Y | LUSC | 1 |
| p.P108S | SKCM | 1 |
| p.P228S | SKCM | 1 |
| p.S140R | LUSC | 1 |
| p.P425S | UVM | 1 |
| p.R53Q | READ | 1 |
| p.Q74K | HNSC | 1 |
| p.M1I | SKCM | 1 |
| p.G90R | SARC | 1 |
| p.V213M | HNSC | 1 |
| p.G69R | SKCM | 1 |
| p.G69E | SKCM | 1 |
| p.R226Q | LGG | 1 |
| p.H260Y | LUSC | 1 |
| p.G83* | HNSC | 1 |
| p.F78L | HNSC | 1 |
| p.G417E | LUSC | 1 |
| p.D206Y | BLCA | 1 |
| p.L211P | PAAD | 1 |
| p.R351T | CESC | 1 |
| p.K348M | LUAD | 1 |
| p.P58S | SARC | 1 |
| p.M174I | SKCM | 1 |
| p.G64V | STAD | 1 |
| p.F212L | LUSC | 1 |
| p.R262S | LUAD | 1 |
| p.I415T | LUAD | 1 |
| p.A422P | KIRP | 1 |
| p.Y129* | KIRC | 1 |
| p.P281S | THCA | 1 |
| p.A290S | KIRC | 1 |
| p.V213M | PAAD | 1 |
| p.G83R | ESCA | 1 |
| p.H340L | HNSC | 1 |
| p.L145F | BRCA | 1 |
| p.L423P | LUAD | 1 |
| p.G95X | ESCA | 1 |
| p.F146V | COAD | 1 |
| p.A199D | HNSC | 1 |
| p.Q185H | UCEC | 1 |
| p.L19V | GBM | 1 |
| p.Y94H | SKCM | 1 |
| p.Q182L | LIHC | 1 |
| p.E358K | BLCA | 1 |
| p.Y267H | SKCM | 1 |
| p.G4C | UCS | 1 |
| p.P276S | SKCM | 1 |
| p.T112M | PAAD | 1 |
| p.V343L | OV | 1 |
| p.T112M | MESO | 1 |
| p.G238R | STAD | 1 |
| p.F399L | DLBC | 1 |
| p.R412Q | UCEC | 1 |
| p.P58S | SKCM | 1 |
| p.G57R | SKCM | 1 |
| p.P425R | OV | 1 |
| p.R110H | READ | 1 |
| p.P108S | THCA | 1 |
| p.G181D | LUAD | 1 |
| p.Q52P | LUSC | 1 |
| p.H265Y | UCEC | 1 |
| p.D48N | CESC | 1 |
| p.P321S | SKCM | 1 |
| p.H260Y | SKCM | 1 |
| p.D48A | COAD | 1 |
| p.G188C | UCEC | 1 |
| p.S59L | HNSC | 1 |
| p.W100C | BLCA | 1 |
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| TissGeneCNV for PLA1A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PLA1A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for PLA1A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| COAD (tumor) | COAD (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| KICH (tumor) | KICH (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| STAD (tumor) | STAD (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| THCA (tumor) | THCA (normal) |
| PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (tumor) | PLA1A, XRCC5, ANXA2, HNF1A, PARP1, PRKDC, XRCC6, ERG (normal) |
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| TissGeneProg for PLA1A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PLA1A |
| TissGeneDrug for PLA1A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PLA1A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C3714756 | Intellectual Disability | 2 | BeFree |
| umls:C0000768 | Congenital Abnormality | 1 | BeFree |
| umls:C0008073 | Developmental Disabilities | 1 | BeFree |
| umls:C0013264 | Muscular Dystrophy, Duchenne | 1 | BeFree |
| umls:C0023931 | Lobstein's Disease | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0027868 | Neuromuscular Diseases | 1 | BeFree |
| umls:C0029434 | Osteogenesis Imperfecta | 1 | BeFree |
| umls:C0340543 | Familial primary pulmonary hypertension | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
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