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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for IL23A
check button Gene summary
Basic gene informationGene symbolIL23A
Gene nameinterleukin 23, alpha subunit p19
SynonymsIL-23|IL-23A|IL23P19|P19|SGRF
CytomapUCSC genome browser: 12q13.3
Type of geneprotein-coding
RefGenesNM_016584.2,
DescriptionIL-23 subunit alphaIL-23-AIL-23p19JKA3 induced upon T-cell activationinterleukin 23 p19 subunitinterleukin-23 subunit alphainterleukin-23 subunit p19interleukin-six, G-CSF related factor
Modification date20141222
dbXrefs MIM : 605580
HGNC : HGNC
Ensembl : ENSG00000110944
HPRD : 12026
Vega : OTTHUMG00000187402
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL23A
BioGPS: 51561
PathwayNCI Pathway Interaction Database: IL23A
KEGG: IL23A
REACTOME: IL23A
Pathway Commons: IL23A
ContextiHOP: IL23A
ligand binding site mutation search in PubMed: IL23A
UCL Cancer Institute: IL23A
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)PancreasTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAADTGCT
Reference showing the relevant tissue of IL23A
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0002230positive regulation of defense response to virus by host12421946
GO:0002827positive regulation of T-helper 1 type immune response15114670
GO:0010535positive regulation of activation of JAK2 kinase activity12023369
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production20027291
GO:0032729positive regulation of interferon-gamma production11114383
GO:0032733positive regulation of interleukin-10 production15265908
GO:0032735positive regulation of interleukin-12 production20027291
GO:0032740positive regulation of interleukin-17 production16482511
GO:0032819positive regulation of natural killer cell proliferation19088061
GO:0042102positive regulation of T cell proliferation12023369
GO:0042104positive regulation of activated T cell proliferation11114383
GO:0042510regulation of tyrosine phosphorylation of Stat1 protein12023369
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein12023369
GO:0042520positive regulation of tyrosine phosphorylation of Stat4 protein11114383
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 protein12023369
GO:0045672positive regulation of osteoclast differentiation17888176
GO:0050829defense response to Gram-negative bacterium15114670
GO:0051135positive regulation of NK T cell activation19088061
GO:0051142positive regulation of NK T cell proliferation19088061
GO:0002230positive regulation of defense response to virus by host12421946
GO:0002827positive regulation of T-helper 1 type immune response15114670
GO:0010535positive regulation of activation of JAK2 kinase activity12023369
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor production20027291
GO:0032729positive regulation of interferon-gamma production11114383
GO:0032733positive regulation of interleukin-10 production15265908
GO:0032735positive regulation of interleukin-12 production20027291
GO:0032740positive regulation of interleukin-17 production16482511
GO:0032819positive regulation of natural killer cell proliferation19088061
GO:0042102positive regulation of T cell proliferation12023369
GO:0042104positive regulation of activated T cell proliferation11114383
GO:0042510regulation of tyrosine phosphorylation of Stat1 protein12023369
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein12023369
GO:0042520positive regulation of tyrosine phosphorylation of Stat4 protein11114383
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 protein12023369
GO:0045672positive regulation of osteoclast differentiation17888176
GO:0050829defense response to Gram-negative bacterium15114670
GO:0051135positive regulation of NK T cell activation19088061
GO:0051142positive regulation of NK T cell proliferation19088061


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TissGeneExp for IL23A

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC1.192987626-1.219377082.4123647061.49E-137.57E-13
LUAD0.62265551-1.5033410422.1259965526.29E-124.49E-11
COAD1.029172618-1.8436696892.8728423081.49E-123.63E-11
ESCA0.832916325-1.8465927662.6795090910.0001810.004969679
STAD0.407585359-1.1833333911.590918750.0004380.002759277


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TissGene-miRNA for IL23A

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for IL23A
TissGeneSNV for IL23A

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A47VUCEC1
p.G76SSTAD1
p.P137LSKCM1
p.S119NUCEC1
p.D67NSKCM1
p.G81XLIHC1
p.K164NUCEC1
p.Q80KPRAD1
p.Q87*BLCA1
p.D107GLGG1
p.G81*UCEC1
p.G105RLIHC1
p.Q136HKIRC1
p.S106LCESC1
p.R158HSTAD1


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TissGeneCNV for IL23A

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for IL23A

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for IL23A

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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COAD (tumor)COAD (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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HNSC (tumor)HNSC (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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KICH (tumor)KICH (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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KIRC (tumor)KIRC (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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KIRP (tumor)KIRP (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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LIHC (tumor)LIHC (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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LUAD (tumor)LUAD (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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LUSC (tumor)LUSC (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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PRAD (tumor)PRAD (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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THCA (tumor)THCA (normal)
IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (tumor)IL23A, RELA, REL, DDIT3, IRF5, IL12B, IL12RB1, IL23R (normal)
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TissGeneProg for IL23A

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for IL23A
TissGeneDrug for IL23A

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for IL23A

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0033860Psoriasis44BeFree,CTD_human,GAD,LHGDN
umls:C0206659Embryonal Carcinoma26BeFree
umls:C0004364Autoimmune Diseases19BeFree,LHGDN
umls:C0003873Rheumatoid Arthritis18BeFree,CTD_human,LHGDN
umls:C0021390Inflammatory Bowel Diseases17BeFree,LHGDN
umls:C0026769Multiple Sclerosis11BeFree,LHGDN
umls:C0038013Ankylosing spondylitis10BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis9BeFree
umls:C0003872Arthritis, Psoriatic8BeFree,LHGDN
umls:C0023493Adult T-Cell Lymphoma/Leukemia8BeFree
umls:C0009324Ulcerative Colitis7BeFree
umls:C0009402Colorectal Carcinoma7BeFree
umls:C0024141Lupus Erythematosus, Systemic7BeFree,LHGDN
umls:C0010346Crohn Disease6BeFree,LHGDN
umls:C0003864Arthritis5BeFree
umls:C0004943Behcet Syndrome5BeFree,LHGDN
umls:C0027627Neoplasm Metastasis5BeFree
umls:C0029408Degenerative polyarthritis5BeFree
umls:C1527249Colorectal Cancer5BeFree
umls:C0011603Dermatitis4BeFree
umls:C0021368Inflammation4LHGDN
umls:C0041296Tuberculosis4BeFree
umls:C0042769Virus Diseases4BeFree
umls:C0178874Tumor Progression4BeFree
umls:C0238790bone destruction4BeFree
umls:C0596263Carcinogenesis4BeFree
umls:C0004096Asthma3BeFree
umls:C0009319Colitis3BeFree
umls:C0011615Dermatitis, Atopic3BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent3BeFree
umls:C0013595Eczema3BeFree
umls:C0018213Graves Disease3BeFree
umls:C0026946Mycoses3BeFree
umls:C0037274Dermatologic disorders3BeFree
umls:C0206664Teratocarcinoma3BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site3BeFree
umls:C0409974Lupus Erythematosus3BeFree
umls:C0007847Malignant tumor of cervix2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0019196Hepatitis C2BeFree,GAD
umls:C0023492Leukemia, T-Cell2BeFree
umls:C0024131Lupus Vulgaris2BeFree
umls:C0024138Lupus Erythematosus, Discoid2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0025202melanoma2BeFree
umls:C0026269Mitral Valve Stenosis2BeFree
umls:C0026764Multiple Myeloma2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0032285Pneumonia2BeFree
umls:C0036117Salmonella infections2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0085110Severe Combined Immunodeficiency2BeFree
umls:C0085669Acute leukemia2BeFree
umls:C0263361Psoriasis vulgaris2BeFree
umls:C0263641Epithelial hyperplasia of skin2BeFree
umls:C0302592Cervix carcinoma2BeFree
umls:C0524909Hepatitis B, Chronic2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C0850666Helicobacter pylori infection2BeFree
umls:C0971858Arthritis, Collagen-Induced2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1290884Inflammatory disorder2BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia2BeFree
umls:C0001430Adenoma1BeFree
umls:C0002390Extrinsic allergic alveolitis1BeFree
umls:C0002736Amyotrophic Lateral Sclerosis1BeFree
umls:C0002871Anemia1LHGDN
umls:C0004623Bacterial Infections1BeFree
umls:C0006272Bronchiolitis Obliterans1LHGDN
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007570Celiac Disease1BeFree
umls:C0008311Cholangitis1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0011303Demyelinating Diseases1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0014121Bacterial Endocarditis1BeFree
umls:C0014743Erythema Nodosum1BeFree
umls:C0017638Glioma1BeFree
umls:C0018378Guillain-Barre Syndrome1BeFree
umls:C0021400Influenza1BeFree
umls:C0022658Kidney Diseases1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0024143Lupus Nephritis1BeFree
umls:C0024301Lymphoma, Follicular1BeFree
umls:C0024530Malaria1BeFree
umls:C0026691Mucocutaneous Lymph Node Syndrome1BeFree
umls:C0026948Mycosis Fungoides1BeFree,LHGDN
umls:C0027697Nephritis1BeFree
umls:C0027814Neuritis, Autoimmune, Experimental1BeFree
umls:C0028754Obesity1BeFree
umls:C0030436Parakeratosis1BeFree
umls:C0031511Pheochromocytoma1BeFree
umls:C0035335Retinoblastoma1BeFree
umls:C0036690Septicemia1BeFree
umls:C0036920Sezary Syndrome1BeFree,LHGDN
umls:C0038826Superinfection1BeFree
umls:C0041327Tuberculosis, Pulmonary1BeFree
umls:C0042164Uveitis1BeFree,LHGDN
umls:C0042170Uveomeningoencephalitic Syndrome1BeFree
umls:C0079744Diffuse Large B-Cell Lymphoma1BeFree
umls:C0085695Chronic gastritis1BeFree
umls:C0152031Joint swelling1BeFree
umls:C0152081Pustular psoriasis1BeFree
umls:C0153381Malignant neoplasm of mouth1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0162429Malnutrition1BeFree
umls:C0206716Ganglioglioma1BeFree
umls:C0220641Lip and Oral Cavity Carcinoma1BeFree
umls:C0235782Gallbladder Carcinoma1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0238067Colitis, Collagenous1BeFree
umls:C0238339Hereditary pancreatitis1BeFree
umls:C0239946Fibrosis, Liver1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0242723Parasitemia1BeFree
umls:C0243026Sepsis1BeFree
umls:C0262985Psoriasiform eczema1BeFree
umls:C0263680Chronic arthritis1BeFree
umls:C0339143Thyroid associated opthalmopathies1BeFree
umls:C0349639Juvenile Myelomonocytic Leukemia1BeFree
umls:C0375019Human T-cell lymphotrophic virus, type I [HTLV-I]1BeFree
umls:C0376545Hematologic Neoplasms1BeFree
umls:C0398650Immune thrombocytopenic purpura1BeFree
umls:C0398738Leukocyte adhesion deficiency type 11BeFree
umls:C0400822Colitis, Lymphocytic1BeFree
umls:C0406317Chronic small plaque psoriasis1BeFree
umls:C0409980Primary antiphospholipid syndrome1BeFree
umls:C0442874Neuropathy1BeFree
umls:C0519030Pneumonia due to Klebsiella pneumoniae1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0549297Auricular swelling1BeFree
umls:C0585362Squamous cell carcinoma of mouth1BeFree
umls:C0587248Costello syndrome (disorder)1BeFree
umls:C0677607Hashimoto Disease1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0744310gastritis h pylori1BeFree
umls:C0751356Idiopathic Inflammatory Myopathies1BeFree
umls:C0848771neurological disability1BeFree
umls:C0876973Infectious disease of lung1BeFree
umls:C0949083Nosocomial pneumonia1BeFree
umls:C0949690Spondylarthritis1BeFree
umls:C0949691Spondylarthropathies1BeFree
umls:C1527336Sjogren's Syndrome1LHGDN
umls:C1541923Infective endocarditis1BeFree
umls:C1609538Latent Tuberculosis1BeFree
umls:C1719672Severe Sepsis1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2613439Extramedullary Hematopoiesis (disorder)1BeFree
umls:C3714514Infection1LHGDN
umls:C3850141Acute-On-Chronic Liver Failure1BeFree