TissGeneSummary for PGC |
Gene summary |
Basic gene information | Gene symbol | PGC |
Gene name | progastricsin (pepsinogen C) | |
Synonyms | PEPC|PGII | |
Cytomap | UCSC genome browser: 6p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001166424.1, NM_002630.3, | |
Description | gastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsin | |
Modification date | 20141207 | |
dbXrefs | MIM : 169740 | |
HGNC : HGNC | ||
Ensembl : ENSG00000096088 | ||
HPRD : 01357 | ||
Vega : OTTHUMG00000014683 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PGC | |
BioGPS: 5225 | ||
Pathway | NCI Pathway Interaction Database: PGC | |
KEGG: PGC | ||
REACTOME: PGC | ||
Pathway Commons: PGC | ||
Context | iHOP: PGC | |
ligand binding site mutation search in PubMed: PGC | ||
UCL Cancer Institute: PGC | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Stomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STAD | |
Reference showing the relevant tissue of PGC | In silico analysis of stomach lineage specific gene set expression pattern in gastric cancer. Pandi NS, Suganya S, Rajendran S. Biochem Biophys Res Commun. 2013 Oct 4;439(4):539-46. doi: 10.1016/j.bbrc.2013.09.007. Epub 2013 Sep 8 (pmid:24025679) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PGC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.995308509 | 10.56747125 | -7.572162745 | 6.11E-19 | 6.25E-18 |
COAD | 0.337889354 | -1.735472185 | 2.073361538 | 7.58E-07 | 4.37E-06 |
LIHC | 0.699234431 | -1.908463569 | 2.607698 | 6.56E-06 | 2.89E-05 |
LUAD | 6.765615879 | 10.76374691 | -3.998131034 | 3.86E-09 | 1.84E-08 |
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TissGene-miRNA for PGC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PGC |
TissGeneSNV for PGC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S121F | STAD | 1 |
p.T45I | LIHC | 1 |
p.L43P | THYM | 1 |
p.E202K | SKCM | 1 |
p.E35V | SKCM | 1 |
p.N85H | SKCM | 1 |
p.G219C | LUAD | 1 |
p.T92I | COAD | 1 |
p.G341C | LUSC | 1 |
p.Q154E | SKCM | 1 |
p.G346* | LUSC | 1 |
p.P331A | STAD | 1 |
p.P243L | LUSC | 1 |
p.A108T | PAAD | 1 |
p.Y371H | PAAD | 1 |
p.Q238H | HNSC | 1 |
p.G357S | SKCM | 1 |
p.V244A | SKCM | 1 |
p.G40R | ESCA | 1 |
p.A204T | UCEC | 1 |
p.T62S | KIRP | 1 |
p.D376N | SKCM | 1 |
p.S131Y | SKCM | 1 |
p.L282P | LIHC | 1 |
p.P50A | KIRP | 1 |
p.Y48H | BLCA | 1 |
p.T193I | COAD | 1 |
p.Q201H | LUAD | 1 |
p.P243L | SKCM | 1 |
p.F74C | KIRC | 1 |
p.P82L | SKCM | 1 |
p.G198D | PRAD | 1 |
p.V212I | BRCA | 1 |
p.L187V | ESCA | 1 |
p.V172I | UCEC | 1 |
p.P82S | HNSC | 1 |
p.E64K | SKCM | 1 |
p.A204T | STAD | 1 |
p.W52S | LUAD | 1 |
p.R55C | BRCA | 1 |
p.Y103C | LUAD | 1 |
p.E247K | SKCM | 1 |
p.L281V | BLCA | 1 |
p.G364R | UCEC | 1 |
p.C10Y | UCEC | 1 |
p.T281A | UCEC | 1 |
p.S95F | SKCM | 1 |
p.T193N | ESCA | 1 |
p.S221T | SARC | 1 |
p.Q246K | OV | 1 |
p.Y103S | OV | 1 |
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TissGeneCNV for PGC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PGC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW869314 | PGC-PGC | chr6:41707606 | chr6:41708252 | |
Chimerdb3.0 | ChiTaRs | NA | AW863384 | PGC-PGC | chr6:41705502 | chr6:41710075 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A939-01A | PGC-PGA3 | 3'UTR-CDS | chr6:41704448 | chr11:60980024 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OJ-11A | PGC-PGA3 | In-Frame | chr6:41705467 | chr11:60980024 |
TCGAfusionPortal | PRADA | GBM | TCGA-06-0129-01A | GTF2H3-PGC | In-frame | Chr12:124123890 | Chr6:41705566 |
TCGAfusionPortal | PRADA | LUAD | TCGA-97-8174-01A | NCOR2-PGC | NA | Chr12:124809926 | Chr6:41715135 |
TCGAfusionPortal | PRADA | OV | TCGA-09-0367-01A | TFEB-PGC | 5UTR-CDS | Chr6:41703088 | Chr6:41711127 |
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TissGeneNet for PGC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PGC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PGC |
TissGeneDrug for PGC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PGC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 14 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 11 | BeFree,GAD |
umls:C0699791 | Stomach Carcinoma | 10 | BeFree |
umls:C0011847 | Diabetes | 7 | BeFree |
umls:C0011849 | Diabetes Mellitus | 7 | BeFree |
umls:C0017154 | Gastritis, Atrophic | 6 | BeFree,GAD |
umls:C0020538 | Hypertensive disease | 6 | BeFree |
umls:C0028754 | Obesity | 6 | BeFree |
umls:C0038356 | Stomach Neoplasms | 5 | GAD,LHGDN |
umls:C0036341 | Schizophrenia | 3 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 3 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0600139 | Prostate carcinoma | 3 | BeFree |
umls:C0005586 | Bipolar Disorder | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree,GAD |
umls:C0011570 | Mental Depression | 2 | BeFree |
umls:C0011581 | Depressive disorder | 2 | BeFree |
umls:C0013295 | Duodenal Ulcer | 2 | BeFree |
umls:C0026846 | Muscular Atrophy | 2 | BeFree |
umls:C0029928 | Ovarian Diseases | 2 | BeFree |
umls:C0038358 | Gastric ulcer | 2 | BeFree,GAD |
umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 2 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 2 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0004134 | Ataxia | 1 | BeFree |
umls:C0006145 | Breast Diseases | 1 | BeFree |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0007193 | Cardiomyopathy, Dilated | 1 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0010520 | Cyanosis | 1 | BeFree |
umls:C0011265 | Presenile dementia | 1 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0014130 | Endocrine System Diseases | 1 | BeFree |
umls:C0015695 | Fatty Liver | 1 | BeFree |
umls:C0018799 | Heart Diseases | 1 | BeFree |
umls:C0020179 | Huntington Disease | 1 | BeFree |
umls:C0020456 | Hyperglycemia | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0025202 | melanoma | 1 | LHGDN |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0030920 | Peptic Ulcer | 1 | BeFree |
umls:C0032708 | Disorders of Porphyrin Metabolism | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | BeFree,GAD |
umls:C0036631 | Seminoma | 1 | BeFree |
umls:C0038354 | Stomach Diseases | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0079487 | Helicobacter Infections | 1 | GAD |
umls:C0085580 | Essential Hypertension | 1 | BeFree |
umls:C0149721 | Left Ventricular Hypertrophy | 1 | BeFree |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0267159 | Superficial gastritis | 1 | BeFree |
umls:C0268095 | Keshan disease | 1 | BeFree |
umls:C0278701 | Gastric Adenocarcinoma | 1 | BeFree |
umls:C0333463 | Senile Plaques | 1 | BeFree |
umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
umls:C0497327 | Dementia | 1 | BeFree |
umls:C0574083 | 3-Methylglutaconic aciduria type 2 | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
umls:C0878544 | Cardiomyopathies | 1 | BeFree |
umls:C1112576 | Antral ulcer | 1 | BeFree |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
umls:C2711227 | Steatohepatitis | 1 | BeFree |