TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PGC
check button Gene summary
Basic gene informationGene symbolPGC
Gene nameprogastricsin (pepsinogen C)
SynonymsPEPC|PGII
CytomapUCSC genome browser: 6p21.1
Type of geneprotein-coding
RefGenesNM_001166424.1,
NM_002630.3,
Descriptiongastricsinpepsin Cpepsinogen Cpepsinogen group IIpreprogastricsin
Modification date20141207
dbXrefs MIM : 169740
HGNC : HGNC
Ensembl : ENSG00000096088
HPRD : 01357
Vega : OTTHUMG00000014683
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PGC
BioGPS: 5225
PathwayNCI Pathway Interaction Database: PGC
KEGG: PGC
REACTOME: PGC
Pathway Commons: PGC
ContextiHOP: PGC
ligand binding site mutation search in PubMed: PGC
UCL Cancer Institute: PGC
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Stomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STAD
Reference showing the relevant tissue of PGCIn silico analysis of stomach lineage specific gene set expression pattern in gastric cancer. Pandi NS, Suganya S, Rajendran S. Biochem Biophys Res Commun. 2013 Oct 4;439(4):539-46. doi: 10.1016/j.bbrc.2013.09.007. Epub 2013 Sep 8 (pmid:24025679)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for PGC

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC2.99530850910.56747125-7.5721627456.11E-196.25E-18
COAD0.337889354-1.7354721852.0733615387.58E-074.37E-06
LIHC0.699234431-1.9084635692.6076986.56E-062.89E-05
LUAD6.76561587910.76374691-3.9981310343.86E-091.84E-08


Top
TissGene-miRNA for PGC

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for PGC
TissGeneSNV for PGC

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.S121FSTAD1
p.T45ILIHC1
p.L43PTHYM1
p.E202KSKCM1
p.E35VSKCM1
p.N85HSKCM1
p.G219CLUAD1
p.T92ICOAD1
p.G341CLUSC1
p.Q154ESKCM1
p.G346*LUSC1
p.P331ASTAD1
p.P243LLUSC1
p.A108TPAAD1
p.Y371HPAAD1
p.Q238HHNSC1
p.G357SSKCM1
p.V244ASKCM1
p.G40RESCA1
p.A204TUCEC1
p.T62SKIRP1
p.D376NSKCM1
p.S131YSKCM1
p.L282PLIHC1
p.P50AKIRP1
p.Y48HBLCA1
p.T193ICOAD1
p.Q201HLUAD1
p.P243LSKCM1
p.F74CKIRC1
p.P82LSKCM1
p.G198DPRAD1
p.V212IBRCA1
p.L187VESCA1
p.V172IUCEC1
p.P82SHNSC1
p.E64KSKCM1
p.A204TSTAD1
p.W52SLUAD1
p.R55CBRCA1
p.Y103CLUAD1
p.E247KSKCM1
p.L281VBLCA1
p.G364RUCEC1
p.C10YUCEC1
p.T281AUCEC1
p.S95FSKCM1
p.T193NESCA1
p.S221TSARC1
p.Q246KOV1
p.Y103SOV1


Top
TissGeneCNV for PGC

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for PGC

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNAAW869314PGC-PGCchr6:41707606chr6:41708252
Chimerdb3.0ChiTaRsNAAW863384PGC-PGCchr6:41705502chr6:41710075
Chimerdb3.0FusionScanESCATCGA-JY-A939-01APGC-PGA33'UTR-CDSchr6:41704448chr11:60980024
Chimerdb3.0FusionScanESCATCGA-L5-A4OJ-11APGC-PGA3In-Framechr6:41705467chr11:60980024
TCGAfusionPortalPRADAGBMTCGA-06-0129-01AGTF2H3-PGCIn-frameChr12:124123890Chr6:41705566
TCGAfusionPortalPRADALUADTCGA-97-8174-01ANCOR2-PGCNAChr12:124809926Chr6:41715135
TCGAfusionPortalPRADAOVTCGA-09-0367-01ATFEB-PGC5UTR-CDSChr6:41703088Chr6:41711127


Top
TissGeneNet for PGC

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
PGC, CDK9, ESR1, CCNT1 (tumor)PGC, CDK9, ESR1, CCNT1 (normal)
bullet pointbullet point


Top
TissGeneProg for PGC

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for PGC
TissGeneDrug for PGC

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for PGC

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent14BeFree
umls:C0024623Malignant neoplasm of stomach11BeFree,GAD
umls:C0699791Stomach Carcinoma10BeFree
umls:C0011847Diabetes7BeFree
umls:C0011849Diabetes Mellitus7BeFree
umls:C0017154Gastritis, Atrophic6BeFree,GAD
umls:C0020538Hypertensive disease6BeFree
umls:C0028754Obesity6BeFree
umls:C0038356Stomach Neoplasms5GAD,LHGDN
umls:C0036341Schizophrenia3BeFree
umls:C0271650Impaired glucose tolerance3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0005586Bipolar Disorder2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree,GAD
umls:C0011570Mental Depression2BeFree
umls:C0011581Depressive disorder2BeFree
umls:C0013295Duodenal Ulcer2BeFree
umls:C0026846Muscular Atrophy2BeFree
umls:C0029928Ovarian Diseases2BeFree
umls:C0038358Gastric ulcer2BeFree,GAD
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site2BeFree
umls:C0524620Metabolic Syndrome X2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C1458155Mammary Neoplasms2BeFree,LHGDN
umls:C2239176Liver carcinoma2BeFree
umls:C0002395Alzheimer's Disease1BeFree
umls:C0004134Ataxia1BeFree
umls:C0006145Breast Diseases1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0010520Cyanosis1BeFree
umls:C0011265Presenile dementia1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0014130Endocrine System Diseases1BeFree
umls:C0015695Fatty Liver1BeFree
umls:C0018799Heart Diseases1BeFree
umls:C0020179Huntington Disease1BeFree
umls:C0020456Hyperglycemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0025202melanoma1LHGDN
umls:C0026769Multiple Sclerosis1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0030920Peptic Ulcer1BeFree
umls:C0032708Disorders of Porphyrin Metabolism1BeFree
umls:C0032927Precancerous Conditions1BeFree,GAD
umls:C0036631Seminoma1BeFree
umls:C0038354Stomach Diseases1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0079487Helicobacter Infections1GAD
umls:C0085580Essential Hypertension1BeFree
umls:C0149721Left Ventricular Hypertrophy1BeFree
umls:C0205851Germ cell tumor1BeFree
umls:C0267159Superficial gastritis1BeFree
umls:C0268095Keshan disease1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0333463Senile Plaques1BeFree
umls:C0362046Prediabetes syndrome1BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0497327Dementia1BeFree
umls:C05740833-Methylglutaconic aciduria type 21BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0878544Cardiomyopathies1BeFree
umls:C1112576Antral ulcer1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C2711227Steatohepatitis1BeFree