TissGeneSummary for SERPINI2 |
Gene summary |
Basic gene information | Gene symbol | SERPINI2 |
Gene name | serpin peptidase inhibitor, clade I (pancpin), member 2 | |
Synonyms | MEPI|PANCPIN|PI14|TSA2004 | |
Cytomap | UCSC genome browser: 3q26.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001012303.2, NM_006217.4, | |
Description | myoepithelium-derived serine protease inhibitorpancreas-specific protein TSA2004peptidase inhibitor 14protease inhibitor 14serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2serine (or cysteine) proteinase inhibitor, clade I (p | |
Modification date | 20141207 | |
dbXrefs | MIM : 605587 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114204 | ||
HPRD : 05722 | ||
Vega : OTTHUMG00000158231 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SERPINI2 | |
BioGPS: 5276 | ||
Pathway | NCI Pathway Interaction Database: SERPINI2 | |
KEGG: SERPINI2 | ||
REACTOME: SERPINI2 | ||
Pathway Commons: SERPINI2 | ||
Context | iHOP: SERPINI2 | |
ligand binding site mutation search in PubMed: SERPINI2 | ||
UCL Cancer Institute: SERPINI2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of SERPINI2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SERPINI2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.274960509 | 1.464486371 | -1.189525862 | 8.63E-06 | 2.55E-05 |
LUSC | -0.079591418 | 1.489912503 | -1.569503922 | 6.97E-09 | 2.23E-08 |
HNSC | -0.383874455 | 0.618190661 | -1.002065116 | 2.46E-05 | 0.000127829 |
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TissGene-miRNA for SERPINI2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SERPINI2 |
TissGeneSNV for SERPINI2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E102K | SKCM | 2 |
p.P392S | SKCM | 2 |
p.S323L | SKCM | 2 |
p.G387E | SKCM | 2 |
p.D316N | SKCM | 2 |
p.P214S | SKCM | 2 |
p.G399E | SKCM | 2 |
p.G399R | SKCM | 2 |
p.E112K | SKCM | 2 |
p.E169K | SKCM | 2 |
p.E94D | STAD | 1 |
p.S228C | HNSC | 1 |
p.Q330K | KIRC | 1 |
p.G15R | UCEC | 1 |
p.L262F | SKCM | 1 |
p.S230F | SKCM | 1 |
p.E28K | UCEC | 1 |
p.Q330* | HNSC | 1 |
p.G187V | HNSC | 1 |
p.S81L | BLCA | 1 |
p.L89P | CESC | 1 |
p.A120S | KIRC | 1 |
p.N202K | STAD | 1 |
p.D411Y | PAAD | 1 |
p.A264P | LUSC | 1 |
p.G329E | SKCM | 1 |
p.S333L | SKCM | 1 |
p.E139K | SKCM | 1 |
p.E293Q | LUAD | 1 |
p.K291* | SKCM | 1 |
p.Q24* | SKCM | 1 |
p.T321A | COAD | 1 |
p.S363N | READ | 1 |
p.E263K | READ | 1 |
p.R400K | SKCM | 1 |
p.Q269* | SKCM | 1 |
p.G319R | SKCM | 1 |
p.E148G | COAD | 1 |
p.G329R | SKCM | 1 |
p.E38K | SKCM | 1 |
p.Q78P | BLCA | 1 |
p.N207I | SKCM | 1 |
p.L252F | SKCM | 1 |
p.E355K | SKCM | 1 |
p.F96C | ESCA | 1 |
p.P173S | SKCM | 1 |
p.S228F | SKCM | 1 |
p.K25T | READ | 1 |
p.T348I | LUAD | 1 |
p.Q45X | SKCM | 1 |
p.G61E | STAD | 1 |
p.D401N | SKCM | 1 |
p.E139G | SKCM | 1 |
p.E325K | SKCM | 1 |
p.G51E | STAD | 1 |
p.F14L | SKCM | 1 |
p.E319Q | SKCM | 1 |
p.Q68K | HNSC | 1 |
p.Q34X | STAD | 1 |
p.E129K | SKCM | 1 |
p.P49L | SKCM | 1 |
p.K144N | UCEC | 1 |
p.E335K | SKCM | 1 |
p.F336L | UCEC | 1 |
p.E263K | SKCM | 1 |
p.P59H | LUSC | 1 |
p.G319E | SKCM | 1 |
p.E255Q | BLCA | 1 |
p.Q201L | LIHC | 1 |
p.E129G | SKCM | 1 |
p.L384M | UCEC | 1 |
p.E28K | SKCM | 1 |
p.H41Y | LUAD | 1 |
p.G15E | SKCM | 1 |
p.M215I | LUAD | 1 |
p.E238K | SKCM | 1 |
p.I366T | LUAD | 1 |
p.S304Y | BLCA | 1 |
p.Q24* | STAD | 1 |
p.A110S | KIRC | 1 |
p.G409R | SKCM | 1 |
p.E57K | SKCM | 1 |
p.L174V | BLCA | 1 |
p.L6V | COAD | 1 |
p.P224S | SKCM | 1 |
p.K154E | LUSC | 1 |
p.S48L | SKCM | 1 |
p.M226I | STAD | 1 |
p.G170R | ACC | 1 |
p.E284K | SKCM | 1 |
p.S324F | BLCA | 1 |
p.L124V | BRCA | 1 |
p.Q191L | LIHC | 1 |
p.P392S | COAD | 1 |
p.A347S | LUAD | 1 |
p.E271K | SKCM | 1 |
p.E84D | STAD | 1 |
p.E261K | SKCM | 1 |
p.R194K | SKCM | 1 |
p.M216I | COAD | 1 |
p.A218D | LUAD | 1 |
p.M216I | STAD | 1 |
p.F86C | ESCA | 1 |
p.Q70R | UCEC | 1 |
p.V211I | CESC | 1 |
p.P370T | LUAD | 1 |
p.Q24H | COAD | 1 |
p.D401Y | PAAD | 1 |
p.P59L | SKCM | 1 |
p.Q80R | UCEC | 1 |
p.S404L | SKCM | 1 |
p.A346D | LUAD | 1 |
p.E36D | LGG | 1 |
p.E263D | SKCM | 1 |
p.S38F | SKCM | 1 |
p.S167L | LUAD | 1 |
p.E273K | SKCM | 1 |
p.E67K | SKCM | 1 |
p.S58L | SKCM | 1 |
p.S382L | BLCA | 1 |
p.S382L | SKCM | 1 |
p.Q35* | SKCM | 1 |
p.E85* | UCS | 1 |
p.E309Q | SKCM | 1 |
p.I393V | DLBC | 1 |
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TissGeneCNV for SERPINI2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SERPINI2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CK824479 | SERPINI2-MED13L | chr3:167173955 | chr12:116558166 | |
Chimerdb3.0 | ChiTaRs | NA | CK824480 | MED13L-SERPINI2 | chr12:116558273 | chr3:167173569 |
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TissGeneNet for SERPINI2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SERPINI2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SERPINI2 |
TissGeneDrug for SERPINI2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SERPINI2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027092 | Myopia | 1 | BeFree |
umls:C0034951 | Refractive Errors | 1 | BeFree |
umls:C0272170 | Shwachman syndrome | 0 | MGD |
umls:C1850081 | Pancreatic Insufficiency, Combined Exocrine | 0 | MGD |