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| TissGeneSummary for SPA17 |
 Gene summary |
| Basic gene information | Gene symbol | SPA17 |
| Gene name | sperm autoantigenic protein 17 | |
| Synonyms | CT22|SP17|SP17-1 | |
| Cytomap | UCSC genome browser: 11q24.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_017425.3, | |
| Description | cancer/testis antigen 22sperm protein 17sperm surface protein Sp17 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608621 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000064199 | ||
| HPRD : 12272 | ||
| Vega : OTTHUMG00000165927 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPA17 | |
| BioGPS: 53340 | ||
| Pathway | NCI Pathway Interaction Database: SPA17 | |
| KEGG: SPA17 | ||
| REACTOME: SPA17 | ||
| Pathway Commons: SPA17 | ||
| Context | iHOP: SPA17 | |
| ligand binding site mutation search in PubMed: SPA17 | ||
| UCL Cancer Institute: SPA17 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SPA17 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SPA17 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.899495682 | 1.423512318 | -2.323008 | 8.33E-15 | 1.61E-13 |
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| TissGene-miRNA for SPA17 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SPA17 |
| TissGeneSNV for SPA17 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S2L | UCEC | 1 |
| p.R131K | LGG | 1 |
| p.S93P | LGG | 1 |
| p.H72R | STAD | 1 |
| p.E75K | SKCM | 1 |
| p.G127E | BRCA | 1 |
| p.E108K | BLCA | 1 |
| p.E97K | BLCA | 1 |
| p.R126Q | STAD | 1 |
| p.T53I | LIHC | 1 |
| p.S141N | HNSC | 1 |
| p.E75Q | LUAD | 1 |
| p.E59* | CESC | 1 |
| p.P80H | BLCA | 1 |
| p.I121L | SKCM | 1 |
| p.K86Q | STAD | 1 |
| p.R67C | CESC | 1 |
| p.S2L | COAD | 1 |
| p.R67C | COAD | 1 |
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| TissGeneCNV for SPA17 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SPA17 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A23Z-01A | SC5DL-SPA17 | 5'UTR-5'UTR | chr11:121163525 | chr11:124545133 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A23Z-01A | SC5DL-SPA17 | 5'UTR-CDS | chr11:121163525 | chr11:124551284 |
| Chimerdb3.0 | TopHat-Fusion | SARC | TCGA-DX-A23Z-01A | SC5D-SPA17 | Out-of-Frame | chr11:121163524 | chr11:124551284 |
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| TissGeneNet for SPA17 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| COAD (tumor) | COAD (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| KICH (tumor) | KICH (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| STAD (tumor) | STAD (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| THCA (tumor) | THCA (normal) |
| SPA17, ROPN1, AKAP3 (tumor) | SPA17, ROPN1, AKAP3 (normal) |
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| TissGeneProg for SPA17 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SPA17 |
| TissGeneDrug for SPA17 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SPA17 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0026764 | Multiple Myeloma | 5 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 5 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 5 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | BeFree,LHGDN |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree,LHGDN |
| umls:C0018133 | Graft-vs-Host Disease | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | GAD |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0677932 | Progressive Neoplastic Disease | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree,LHGDN |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C3539781 | Progressive cGVHD | 1 | BeFree |
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