TissGeneSummary for PMP2 |
Gene summary |
Basic gene information | Gene symbol | PMP2 |
Gene name | peripheral myelin protein 2 | |
Synonyms | FABP8|M-FABP|MP2|P2 | |
Cytomap | UCSC genome browser: 8q21.3-q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002677.3, | |
Description | myelin P2 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 170715 | |
HGNC : HGNC | ||
Ensembl : ENSG00000147588 | ||
HPRD : 01366 | ||
Vega : OTTHUMG00000164600 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PMP2 | |
BioGPS: 5375 | ||
Pathway | NCI Pathway Interaction Database: PMP2 | |
KEGG: PMP2 | ||
REACTOME: PMP2 | ||
Pathway Commons: PMP2 | ||
Context | iHOP: PMP2 | |
ligand binding site mutation search in PubMed: PMP2 | ||
UCL Cancer Institute: PMP2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of PMP2 | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PMP2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -2.990140864 | -1.248594372 | -1.741546491 | 1.04E-22 | 8.98E-22 |
COAD | -2.434827233 | 1.410434305 | -3.845261538 | 2.82E-19 | 8.83E-17 |
KIRP | -3.068433243 | -0.813198868 | -2.255234375 | 4.60E-12 | 6.61E-11 |
STAD | -1.773667618 | 1.152998007 | -2.926665625 | 1.05E-07 | 2.78E-06 |
PRAD | 0.019245844 | 1.648328536 | -1.629082692 | 2.25E-08 | 2.48E-07 |
KIRC | -2.979280118 | -0.79426484 | -2.185015278 | 3.42E-17 | 2.07E-16 |
KICH | -3.109208618 | -0.898404618 | -2.210804 | 2.96E-08 | 1.47E-07 |
THCA | -3.135716347 | -0.94445194 | -2.191264407 | 6.28E-26 | 1.40E-23 |
LIHC | -3.174244618 | -1.509906618 | -1.664338 | 8.39E-12 | 1.37E-10 |
BLCA | -2.004303144 | 2.180960014 | -4.185263158 | 2.45E-11 | 1.00E-08 |
ESCA | -1.946474436 | 1.411143746 | -3.357618182 | 5.21E-05 | 0.002069114 |
HNSC | -1.290687967 | 0.330256219 | -1.620944186 | 4.61E-05 | 0.000224513 |
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TissGene-miRNA for PMP2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PMP2 |
TissGeneSNV for PMP2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R53Q | UCEC | 2 |
p.R53Q | COAD | 1 |
p.G100D | SKCM | 1 |
p.S2N | ESCA | 1 |
p.V123M | PRAD | 1 |
p.W42* | SKCM | 1 |
p.S2N | ACC | 1 |
p.A116V | STAD | 1 |
p.S14N | COAD | 1 |
p.S64F | SKCM | 1 |
p.L36V | UCEC | 1 |
p.R53Q | SKCM | 1 |
p.M120R | SKCM | 1 |
p.E70D | CESC | 1 |
p.V124L | BRCA | 1 |
p.E70K | SKCM | 1 |
p.K45N | UCEC | 1 |
p.Q96K | LIHC | 1 |
p.Q96* | UCEC | 1 |
p.N35D | LIHC | 1 |
p.F65L | HNSC | 1 |
p.T81S | CESC | 1 |
p.D77G | KIRC | 1 |
p.L6P | UCEC | 1 |
p.R27C | SKCM | 1 |
p.I42V | COAD | 1 |
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TissGeneCNV for PMP2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PMP2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PMP2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PMP2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PMP2 |
TissGeneDrug for PMP2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB04224 | Oleic Acid | Small molecule | Approved|Vet_approved |
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TissGeneDisease for PMP2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 1 | BeFree |