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| TissGeneSummary for DCUN1D1 |
 Gene summary |
| Basic gene information | Gene symbol | DCUN1D1 |
| Gene name | DCN1, defective in cullin neddylation 1, domain containing 1 | |
| Synonyms | DCNL1|DCUN1L1|RP42|SCCRO|SCRO|Tes3 | |
| Cytomap | UCSC genome browser: 3q26.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020640.2, | |
| Description | DCN1-like protein 1DCUN1 domain-containing protein 1RP42 homologdefective in cullin neddylation protein 1-like protein 1squamous cell carcinoma related oncogenesquamous cell carcinoma-related oncogene | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605905 | |
| HGNC : HGNC | ||
| HPRD : 12067 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DCUN1D1 | |
| BioGPS: 54165 | ||
| Pathway | NCI Pathway Interaction Database: DCUN1D1 | |
| KEGG: DCUN1D1 | ||
| REACTOME: DCUN1D1 | ||
| Pathway Commons: DCUN1D1 | ||
| Context | iHOP: DCUN1D1 | |
| ligand binding site mutation search in PubMed: DCUN1D1 | ||
| UCL Cancer Institute: DCUN1D1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DCUN1D1 | ||
| Description by TissGene annotations | Cancer gene TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DCUN1D1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 1.064471642 | -0.417793064 | 1.482264706 | 2.88E-16 | 2.09E-15 |
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| TissGene-miRNA for DCUN1D1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-33a-5p | MIMAT0000091 | 0.022 | -0.26 | 78 |
| ACC | hsa-miR-33a-5p | MIMAT0000091 | 0.022 | -0.26 | 78 |
| LUAD | hsa-miR-424-5p | MIMAT0001341 | 0.049 | -0.26 | 60 |
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| TissGeneMut for DCUN1D1 |
| TissGeneSNV for DCUN1D1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E147* | LUSC | 1 |
| p.Q114* | STAD | 1 |
| p.F117L | STAD | 1 |
| p.N167D | STAD | 1 |
| p.E23K | HNSC | 1 |
| p.G169E | STAD | 1 |
| p.E66* | BRCA | 1 |
| p.Q20* | LGG | 1 |
| p.I134M | LUSC | 1 |
| p.R53Q | SKCM | 1 |
| p.R13S | ESCA | 1 |
| p.F219L | TGCT | 1 |
| p.Q114X | STAD | 1 |
| p.R13C | SKCM | 1 |
| p.Q159K | SKCM | 1 |
| p.S99G | LUAD | 1 |
| p.S101R | OV | 1 |
| p.Q76E | BLCA | 1 |
| p.D194N | BRCA | 1 |
| p.K63N | READ | 1 |
| p.R71T | BLCA | 1 |
| p.Q32E | LUAD | 1 |
| p.E78* | BLCA | 1 |
| p.R13H | LUSC | 1 |
| p.E150* | LUSC | 1 |
| p.M144I | PRAD | 1 |
| p.W107R | UCEC | 1 |
| p.A98V | COAD | 1 |
| p.R248H | STAD | 1 |
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| TissGeneCNV for DCUN1D1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DCUN1D1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BE273347 | DCUN1D1-QTRT1 | chr3:182683538 | chr19:10812792 | |
| Chimerdb3.0 | ChiTaRs | NA | T12477 | DCUN1D1-WWC3 | chr3:182677833 | chrX:10107305 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-A76X-01A | DCUN1D1-SLC22A1 | In-Frame | chr3:182698274 | chr6:160575829 |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-HC-A76X-01A | DCUN1D1-SLC22A1 | In-Frame | chr3:182698274 | chr6:160579547 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A8I1-01A | TBL1XR1-DCUN1D1 | 5'UTR-CDS | chr3:176914908 | chr3:182683541 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A8I1-01A | TBL1XR1-DCUN1D1 | 5'UTR-CDS | chr3:176914908 | chr3:182681837 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A0JM-01A | DCUN1D1-CCDC50 | In-frame | Chr3:182679014 | Chr3:191074877 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-60-2696-01A | MBNL1-DCUN1D1 | In-frame | Chr3:152018156 | Chr3:182683541 |
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| TissGeneNet for DCUN1D1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DCUN1D1, CUL5, CUL2, NEDD4, UBE2M, SHKBP1, SNRPD2, DDX3X, POLR2I, LATS1, SYNCRIP, KLHL23, KLHL15, TNRC6B, RAB40C, ZCCHC11, KLHDC10, PHIP, AGL, ZNF699, KLHL8 (tumor) | DCUN1D1, CAND1, CUL2, SNRNP70, TCEB2, DHX9, TRRAP, DDX3X, RPL18, LATS1, KLHL23, POLL, RPLP2, RAB40C, API5, KLHDC10, UGGT1, PHIP, MYEOV2, ZNF699, KLHL8 (normal) |
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| COAD (tumor) | COAD (normal) |
| DCUN1D1, C14orf166, CUL2, SNRPE, POLR2A, YWHAE, COPS5, TCEB1, RBX1, NEDD8, ARHGEF1, COPS2, COPS4, RNF11, ASB6, PRDX3, SNRPG, SCRIB, SSBP1, API5, MRPS23 (tumor) | DCUN1D1, CAND1, CUL5, CUL2, SNRNP70, EWSR1, COPS2, COPS4, LATS1, RPS2, KLHL23, RNF11, BAG4, POLL, RPLP2, SCRIB, FEM1B, RAB40C, KLHDC10, AGL, ZNF699 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DCUN1D1, CUL5, CUL2, CUL3, HNRNPA1, SNRNP70, TCEB2, COPS2, RPS27A, MTHFD1, LATS1, SOCS6, RNF11, BAG4, POLL, KCTD3, RPLP2, ASB6, COPS7B, KLHDC10, ZNF699 (tumor) | DCUN1D1, SNRNP70, UBE2M, TCEB2, CLTC, DHX9, RPL18, POLR2I, LATS1, RPS2, KLHL23, BAG4, RPLP2, TNRC6B, ZCCHC11, SOCS5, KLHDC10, MYEOV2, ASB3, ZNF699, KLHL8 (normal) |
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| KICH (tumor) | KICH (normal) |
| DCUN1D1, PLOD1, GRB2, NCL, YWHAE, TIAL1, INSR, PABPC1, DHX57, KRT10, DDX1, PRPSAP2, SYNCRIP, KLHL12, CSTB, API5, UGGT1, MRPS23, BFSP1, DCUN1D2, KLHL8 (tumor) | DCUN1D1, CAND1, TIAL1, YWHAB, SNRNP70, UBE2M, TCEB2, CLTC, NEDD8, DHX9, DDX3X, RPL18, COPS4, POLR2I, LATS1, SYNCRIP, BAG4, VPRBP, COPS7B, KLHDC10, UGGT1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DCUN1D1, PLOD1, GRB2, CUL3, MCM3, SMAD2, CLTC, INSR, TXN, ACTBL2, BAG4, DAZAP2, RPL6, KLHL12, CEP76, KLHL9, API5, SOCS5, ASB3, BFSP1, KLHL8 (tumor) | DCUN1D1, FUS, CAND1, CUL5, CUL2, HSPA8, YWHAB, UBE2M, CLTC, RPL18, POLR2I, LATS1, BAG4, RPLP2, DNAJC10, FEM1B, RAB40C, API5, KLHDC10, AGL, KLHL8 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DCUN1D1, PLOD1, GRB2, NCL, YWHAE, TIAL1, SMAD2, TCEB1, TRIM39, DHX9, PABPC1, CUL4A, TXNDC5, PRPSAP2, EML1, KLHL12, LAPTM5, BFSP1, ZNF326, DCUN1D2, KLHL8 (tumor) | DCUN1D1, COPS6, CAND1, CUL2, TCEB2, DHX9, DDX3X, RPL18, POLR2I, LATS1, KLHL23, BAG4, RNMT, RPLP2, VPRBP, CEP76, ZCCHC11, KLHDC10, MYEOV2, ZNF699, KLHL8 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DCUN1D1, CAND1, CUL5, CUL2, UBE2M, CLTC, CUL4A, RPL18, LATS1, RPS2, KLHL23, BAG4, KCTD3, RPLP2, ASB6, TNRC6B, FEM1B, API5, ZCCHC11, MYEOV2, KLHL8 (tumor) | DCUN1D1, CUL5, RPS10, TCEB1, TCEB2, SNRPD2, RPS8, RPL18, POLR2I, LATS1, RPL23A, RPS2, KLHL23, BAG4, RPLP2, TNRC6B, FEM1B, ZCCHC11, KLHDC10, MYEOV2, KLHL8 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DCUN1D1, CUL5, CUL2, SNRPE, ILF3, POLR2A, COPS5, HNRNPUL1, EWSR1, RPS3A, ARHGEF1, COPS2, COPS4, RNF11, PRDX3, SCRIB, FEM1B, SSBP1, FBF1, API5, KLHL26 (tumor) | DCUN1D1, CAND1, CUL2, TFG, HSPA8, YWHAB, SNRNP70, HSP90AA1, ARHGEF1, COPS2, COPS4, KLHL23, RNF11, BAG4, BTBD9, FEM1B, RAB40C, CEP76, API5, C16orf89, ZNF699 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DCUN1D1, CAND1, CUL5, CUL2, TIAL1, COPS5, EWSR1, COPS2, COPS4, TAF15, BAG4, ASB6, PRDX3, SCRIB, FEM1B, RAB40C, CEP76, KLHL9, API5, KLHL26, KLHL8 (tumor) | DCUN1D1, LSM12, SNRNP70, ARHGEF1, DHX9, ASNS, COPS2, COPS4, PRPSAP2, KLHL23, BAG4, KCTD3, STRBP, KRT77, EML1, CBR3, KLHL13, KLHL12, FEM1B, CEP76, ASB3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DCUN1D1, CAND1, CUL5, CUL2, CUL4B, NEDD4, SNRNP70, EWSR1, DDX56, LATS1, KLHL23, RNF11, BAG4, ASB6, FEM1B, RAB40C, API5, SOCS5, KLHDC10, AGL, ZNF699 (tumor) | DCUN1D1, CAND1, UBE2M, TCEB2, CLTC, SNRPD2, TRRAP, RPL18, POLR2I, LATS1, KLHL23, BAG4, RPLP2, VPRBP, TNRC6B, FEM1B, SOCS5, KLHDC10, MYEOV2, ZNF699, KLHL8 (normal) |
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| STAD (tumor) | STAD (normal) |
| DCUN1D1, CAND1, CUL5, CUL2, CUL4B, CUL3, TIAL1, COPS2, TXNDC5, DDX1, HSPA9, RNF11, KCTD3, LGALS3BP, TIA1, KLHL12, FEM1B, CEP76, KLHL9, API5, AGL (tumor) | DCUN1D1, CAND1, CUL5, CUL2, CUL3, SNRNP70, CLTC, DHX9, DDX3X, RPL18, POLR2I, LATS1, RPL23A, RPS2, BAG4, KLHL15, RPLP2, VPRBP, RPL6, AGL, KLHL8 (normal) |
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| THCA (tumor) | THCA (normal) |
| DCUN1D1, CAND1, CUL5, RPS10, TCEB2, SNRPD2, NEDD8, TRRAP, RPL18, POLR2I, LATS1, KLHL23, BAG4, RNMT, SNRPC, FEM1B, KLHL9, KLHDC10, AGL, MYEOV2, KLHL8 (tumor) | DCUN1D1, COPS6, CUL5, RPS10, TCEB2, SNRPD2, RPS8, RPL18, POLR2I, LATS1, SOCS6, KLHL23, BAG4, RPLP2, VPRBP, FEM1B, KLHL9, ZCCHC11, KLHDC10, ZNF699, KLHL8 (normal) |
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| TissGeneProg for DCUN1D1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DCUN1D1 |
| TissGeneDrug for DCUN1D1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DCUN1D1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0002793 | Anaplasia | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0175754 | Agenesis of corpus callosum | 1 | BeFree |
| umls:C0206667 | Adrenal Cortical Adenoma | 1 | BeFree |
| umls:C0206686 | Adrenocortical carcinoma | 1 | BeFree,LHGDN |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0497327 | Dementia | 1 | GAD |
| umls:C0751072 | Frontotemporal Lobar Degeneration | 1 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
| umls:C3811918 | GRN-related frontotemporal dementia | 1 | BeFree |
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