TissGeneSummary for HAO1 |
Gene summary |
Basic gene information | Gene symbol | HAO1 |
Gene name | hydroxyacid oxidase (glycolate oxidase) 1 | |
Synonyms | GOX|GOX1|HAOX1 | |
Cytomap | UCSC genome browser: 20p12 | |
Type of gene | protein-coding | |
RefGenes | NM_017545.2, | |
Description | (S)-2-hydroxy-acid oxidaseglycolate oxidasehydroxyacid oxidase 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605023 | |
HGNC : HGNC | ||
Ensembl : ENSG00000101323 | ||
HPRD : 05429 | ||
Vega : OTTHUMG00000031841 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HAO1 | |
BioGPS: 54363 | ||
Pathway | NCI Pathway Interaction Database: HAO1 | |
KEGG: HAO1 | ||
REACTOME: HAO1 | ||
Pathway Commons: HAO1 | ||
Context | iHOP: HAO1 | |
ligand binding site mutation search in PubMed: HAO1 | ||
UCL Cancer Institute: HAO1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of HAO1 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0001561 | fatty acid alpha-oxidation | 18215067 | GO:0046296 | glycolate catabolic process | 18215067 | GO:0001561 | fatty acid alpha-oxidation | 18215067 | GO:0046296 | glycolate catabolic process | 18215067 |
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TissGeneExp for HAO1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -1.913140624 | 0.646784376 | -2.559925 | 1.42E-07 | 8.33E-07 |
LIHC | 9.283019376 | 11.29257738 | -2.009558 | 4.89E-07 | 2.84E-06 |
KIRC | -2.164279513 | 0.071588542 | -2.235868056 | 3.32E-12 | 1.36E-11 |
PRAD | -0.456906009 | -1.57020024 | 1.113294231 | 0.000815 | 0.002693827 |
KICH | -2.334840624 | -0.710180624 | -1.62466 | 0.00108 | 0.002333647 |
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TissGene-miRNA for HAO1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-1297 | MIMAT0005886 | 0.025 | -0.26 | 78 |
ACC | hsa-miR-1297 | MIMAT0005886 | 0.025 | -0.26 | 78 |
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TissGeneMut for HAO1 |
TissGeneSNV for HAO1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M105I | SKCM | 2 |
p.E116K | HNSC | 1 |
p.R145W | KIRP | 1 |
p.L333F | SKCM | 1 |
p.A235T | HNSC | 1 |
p.S100F | SKCM | 1 |
p.E59D | UCEC | 1 |
p.R4W | OV | 1 |
p.V318I | COAD | 1 |
p.M85K | LGG | 1 |
p.H260D | BLCA | 1 |
p.D202N | READ | 1 |
p.A235V | STAD | 1 |
p.G284W | HNSC | 1 |
p.I317M | BRCA | 1 |
p.P195S | PAAD | 1 |
p.Y134* | LUSC | 1 |
p.A31S | STAD | 1 |
p.A308T | STAD | 1 |
p.F193V | STAD | 1 |
p.P51S | HNSC | 1 |
p.Q324H | BLCA | 1 |
p.A303S | LUAD | 1 |
p.L306F | SKCM | 1 |
p.Y208F | LUAD | 1 |
p.D33N | CESC | 1 |
p.V18L | HNSC | 1 |
p.S63L | BRCA | 1 |
p.R245M | ACC | 1 |
p.D202Y | CHOL | 1 |
p.E35* | LUAD | 1 |
p.D201Y | LUSC | 1 |
p.H87Y | BRCA | 1 |
p.N40H | DLBC | 1 |
p.G254W | LUAD | 1 |
p.R55W | UCEC | 1 |
p.S192* | LUAD | 1 |
p.D160N | SKCM | 1 |
p.E91K | LUSC | 1 |
p.P179L | COAD | 1 |
p.N40K | HNSC | 1 |
p.R145W | PRAD | 1 |
p.A207T | LUSC | 1 |
p.A244T | STAD | 1 |
p.Q350H | LUAD | 1 |
p.G165D | LIHC | 1 |
p.V279A | LUAD | 1 |
p.Q264E | LUAD | 1 |
p.S192* | CESC | 1 |
p.R28G | HNSC | 1 |
p.A31G | BRCA | 1 |
p.D33N | SKCM | 1 |
p.W47* | SKCM | 1 |
p.D160G | HNSC | 1 |
p.A322D | BLCA | 1 |
p.T64P | GBM | 1 |
p.A322V | UCEC | 1 |
p.R245T | LUAD | 1 |
p.Q180E | LUAD | 1 |
p.M53I | HNSC | 1 |
p.W224L | BLCA | 1 |
p.V367I | ESCA | 1 |
p.K211E | LUSC | 1 |
p.V367I | GBM | 1 |
p.E197K | SKCM | 1 |
p.G251D | LUAD | 1 |
p.G284V | HNSC | 1 |
p.R55Q | UCEC | 1 |
p.L304R | HNSC | 1 |
p.T229K | LUSC | 1 |
p.M344V | BLCA | 1 |
p.S230P | STAD | 1 |
p.E246K | SKCM | 1 |
p.V268M | PRAD | 1 |
p.S258L | SKCM | 1 |
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TissGeneCNV for HAO1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HAO1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for HAO1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HAO1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HAO1 |
TissGeneDrug for HAO1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HAO1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020500 | Hyperoxaluria | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0268164 | Primary hyperoxaluria, type I | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | GAD |