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| TissGeneSummary for TAF7L |
 Gene summary |
| Basic gene information | Gene symbol | TAF7L |
| Gene name | TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa | |
| Synonyms | CT40|TAF2Q | |
| Cytomap | UCSC genome browser: Xq22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001168474.1, NM_024885.3, | |
| Description | RNA polymerase II TBP-associated factor subunit QTATA box-binding protein-associated factor 50 kDaTBP-associated factor, RNA polymerase II, Qcancer/testis antigen 40transcription initiation factor TFIID 50 kDa subunittranscription initiation factor T | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300314 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000102387 | ||
| HPRD : 02259 | ||
| Vega : OTTHUMG00000022021 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TAF7L | |
| BioGPS: 54457 | ||
| Pathway | NCI Pathway Interaction Database: TAF7L | |
| KEGG: TAF7L | ||
| REACTOME: TAF7L | ||
| Pathway Commons: TAF7L | ||
| Context | iHOP: TAF7L | |
| ligand binding site mutation search in PubMed: TAF7L | ||
| UCL Cancer Institute: TAF7L | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of TAF7L | Taf7l cooperates with Trf2 to regulate spermiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16886-91. doi: (pmid:24082143) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TAF7L |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.914623503 | 0.651980664 | -1.566604167 | 1.68E-15 | 8.74E-15 |
| LUAD | -0.228243761 | -1.515219623 | 1.286975862 | 1.28E-05 | 3.70E-05 |
| LUSC | -0.161840414 | -1.324491395 | 1.16265098 | 1.29E-07 | 3.59E-07 |
| PRAD | -0.441276387 | 1.369475536 | -1.810751923 | 8.86E-11 | 1.97E-09 |
| KICH | 3.716176997 | 0.841488997 | 2.874688 | 3.53E-07 | 1.45E-06 |
| KIRP | -0.725861003 | 0.788670247 | -1.51453125 | 2.46E-06 | 1.14E-05 |
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| TissGene-miRNA for TAF7L |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TAF7L |
| TissGeneSNV for TAF7L |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E341D | KIRC | 4 |
| p.S12L | SKCM | 2 |
| p.D340E | KIRC | 2 |
| p.E447G | LUSC | 1 |
| p.S11Y | READ | 1 |
| p.P298L | SKCM | 1 |
| p.L301F | HNSC | 1 |
| p.D342H | UCS | 1 |
| p.V261M | KIRP | 1 |
| p.E347D | CESC | 1 |
| p.E89D | ACC | 1 |
| p.D335E | KIRC | 1 |
| p.E262K | HNSC | 1 |
| p.M392I | SKCM | 1 |
| p.A189V | SKCM | 1 |
| p.E97K | BLCA | 1 |
| p.M320I | LUAD | 1 |
| p.E292K | SKCM | 1 |
| p.E5K | SKCM | 1 |
| p.R138C | CESC | 1 |
| p.A275V | SKCM | 1 |
| p.L108M | UCEC | 1 |
| p.D342H | BLCA | 1 |
| p.P49S | READ | 1 |
| p.E206X | COAD | 1 |
| p.M125I | CESC | 1 |
| p.S271L | BLCA | 1 |
| p.D186N | BLCA | 1 |
| p.K445I | UCS | 1 |
| p.K232* | STAD | 1 |
| p.D340N | BRCA | 1 |
| p.E246* | UCEC | 1 |
| p.D200G | READ | 1 |
| p.K310R | BLCA | 1 |
| p.A77T | DLBC | 1 |
| p.Y318H | ESCA | 1 |
| p.L156F | GBM | 1 |
| p.F289Y | SKCM | 1 |
| p.A77G | DLBC | 1 |
| p.E209* | UCEC | 1 |
| p.E436* | LUAD | 1 |
| p.D68N | SKCM | 1 |
| p.E267K | SKCM | 1 |
| p.D36N | UCEC | 1 |
| p.P58L | SKCM | 1 |
| p.R322W | UCEC | 1 |
| p.S315L | SKCM | 1 |
| p.Q457X | THYM | 1 |
| p.N332D | KIRC | 1 |
| p.R149W | COAD | 1 |
| p.P58T | UCEC | 1 |
| p.E79K | UCEC | 1 |
| p.E454G | LIHC | 1 |
| p.Q444P | LUSC | 1 |
| p.P135_splice | GBM | 1 |
| p.D344H | CESC | 1 |
| p.D176H | GBM | 1 |
| p.Y255N | LUAD | 1 |
| p.T426S | BRCA | 1 |
| p.Y43F | LIHC | 1 |
| p.M87I | LUAD | 1 |
| p.E281X | KIRC | 1 |
| p.R138C | HNSC | 1 |
| p.F375Y | SKCM | 1 |
| p.A71V | SKCM | 1 |
| p.D417Y | GBM | 1 |
| p.S120Y | UCEC | 1 |
| p.Q7H | LUAD | 1 |
| p.K445Q | UCEC | 1 |
| p.Q91L | LUAD | 1 |
| p.S222G | COAD | 1 |
| p.E290K | SKCM | 1 |
| p.R458C | KIRC | 1 |
| p.S178Y | UCEC | 1 |
| p.M306L | BLCA | 1 |
| p.E204K | SKCM | 1 |
| p.Q76H | DLBC | 1 |
| p.E353K | KIRC | 1 |
| p.I204T | LGG | 1 |
| p.E393K | SKCM | 1 |
| p.K232X | STAD | 1 |
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| TissGeneCNV for TAF7L |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TAF7L |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4382-01A | UNC13B-TAF7L | Out-of-frame | Chr9:35162302 | ChrX:100524225 |
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| TissGeneNet for TAF7L |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| COAD (tumor) | COAD (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| KICH (tumor) | KICH (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| STAD (tumor) | STAD (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| THCA (tumor) | THCA (normal) |
| TAF7L, TBP, TAF13, TAF1 (tumor) | TAF7L, TBP, TAF13, TAF1 (normal) |
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| TissGeneProg for TAF7L |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TAF7L |
| TissGeneDrug for TAF7L |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TAF7L |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0021364 | Male infertility | 1 | LHGDN |
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