TissGeneSummary for POU3F2 |
Gene summary |
Basic gene information | Gene symbol | POU3F2 |
Gene name | POU class 3 homeobox 2 | |
Synonyms | BRN2|N-Oct3|OCT7|OTF-7|OTF7|POUF3|brn-2|oct-7 | |
Cytomap | UCSC genome browser: 6q16 | |
Type of gene | protein-coding | |
RefGenes | NM_005604.3, | |
Description | POU domain, class 3, transcription factor 2brain-2brain-specific homeobox/POU domain protein 2nervous system-specific octamer-binding transcription factor N-Oct-3octamer-binding protein 7octamer-binding transcription factor 7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600494 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184486 | ||
HPRD : 02734 | ||
Vega : OTTHUMG00000015258 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POU3F2 | |
BioGPS: 5454 | ||
Pathway | NCI Pathway Interaction Database: POU3F2 | |
KEGG: POU3F2 | ||
REACTOME: POU3F2 | ||
Pathway Commons: POU3F2 | ||
Context | iHOP: POU3F2 | |
ligand binding site mutation search in PubMed: POU3F2 | ||
UCL Cancer Institute: POU3F2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of POU3F2 | ||
Description by TissGene annotations | Risk TissGene in OS Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0008284 | positive regulation of cell proliferation | 15024079 | GO:0008284 | positive regulation of cell proliferation | 15024079 |
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TissGeneExp for POU3F2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.409526357 | -2.156952953 | 2.56647931 | 8.89E-08 | 3.50E-07 |
LUSC | -0.254785373 | -2.144740275 | 1.889954902 | 1.15E-06 | 2.87E-06 |
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TissGene-miRNA for POU3F2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-148b-3p | MIMAT0000759 | 0.024 | -0.26 | 78 |
ACC | hsa-miR-148b-3p | MIMAT0000759 | 0.024 | -0.26 | 78 |
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TissGeneMut for POU3F2 |
TissGeneSNV for POU3F2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.K354T | BLCA | 1 |
p.M27I | COAD | 1 |
p.L316M | LUAD | 1 |
p.G340C | BLCA | 1 |
p.E271K | SARC | 1 |
p.V365F | ESCA | 1 |
p.R355W | UCEC | 1 |
p.E409* | UCEC | 1 |
p.E36K | STAD | 1 |
p.P414L | LIHC | 1 |
p.A349T | UCEC | 1 |
p.P414L | BLCA | 1 |
p.A254T | ESCA | 1 |
p.R353H | STAD | 1 |
p.E409D | PAAD | 1 |
p.R281Q | STAD | 1 |
p.P23Q | SARC | 1 |
p.P245S | LUSC | 1 |
p.A159T | PAAD | 1 |
p.Y426X | COAD | 1 |
p.L316Q | LUAD | 1 |
p.E271K | BLCA | 1 |
p.T287A | COAD | 1 |
p.H236Q | LUAD | 1 |
p.R114H | ESCA | 1 |
p.P326S | HNSC | 1 |
p.A422G | BRCA | 1 |
p.P193H | LUSC | 1 |
p.P242L | STAD | 1 |
p.R358Q | COAD | 1 |
p.H255Q | LUAD | 1 |
p.E36Q | LUSC | 1 |
p.G186C | STAD | 1 |
p.D263G | OV | 1 |
p.S56R | LUAD | 1 |
p.F311L | STAD | 1 |
p.S15G | STAD | 1 |
p.S380* | CESC | 1 |
p.R353C | COAD | 1 |
p.G296S | STAD | 1 |
p.R280W | READ | 1 |
p.G352R | SKCM | 1 |
p.E36* | HNSC | 1 |
p.A368V | UCEC | 1 |
p.S386Y | LIHC | 1 |
p.V291M | LIHC | 1 |
p.G52V | LUAD | 1 |
p.S338T | LUSC | 1 |
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TissGeneCNV for POU3F2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POU3F2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF127989 | MAML3-POU3F2 | chr4:141287934 | chr6:99283155 |
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TissGeneNet for POU3F2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POU3F2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POU3F2 |
TissGeneDrug for POU3F2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POU3F2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 19 | BeFree,LHGDN |
umls:C0026010 | Microphthalmos | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
umls:C0036341 | Schizophrenia | 2 | BeFree,GAD |
umls:C0149925 | Small cell carcinoma of lung | 2 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0005586 | Bipolar Disorder | 1 | BeFree |
umls:C0007129 | Merkel cell carcinoma | 1 | BeFree |
umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
umls:C0018817 | Atrial Septal Defects | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | BeFree |
umls:C0025267 | Multiple Endocrine Neoplasia Type 1 | 1 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C1510586 | Autism Spectrum Disorders | 1 | BeFree |