TissGeneSummary for POU4F1 |
Gene summary |
Basic gene information | Gene symbol | POU4F1 |
Gene name | POU class 4 homeobox 1 | |
Synonyms | BRN3A|Oct-T1|RDC-1|brn-3A | |
Cytomap | UCSC genome browser: 13q31.1 | |
Type of gene | protein-coding | |
RefGenes | NM_006237.3, | |
Description | POU domain, class 4, transcription factor 1brain-3Abrain-specific homeobox/POU domain protein 3Ahomeobox/POU domain protein RDC-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601632 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152192 | ||
HPRD : 03379 | ||
Vega : OTTHUMG00000017119 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POU4F1 | |
BioGPS: 5457 | ||
Pathway | NCI Pathway Interaction Database: POU4F1 | |
KEGG: POU4F1 | ||
REACTOME: POU4F1 | ||
Pathway Commons: POU4F1 | ||
Context | iHOP: POU4F1 | |
ligand binding site mutation search in PubMed: POU4F1 | ||
UCL Cancer Institute: POU4F1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of POU4F1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for POU4F1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.131001482 | -1.224235773 | 2.355237255 | 1.07E-10 | 4.03E-10 |
LUAD | 0.596252428 | -1.383495847 | 1.979748276 | 7.45E-08 | 2.95E-07 |
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TissGene-miRNA for POU4F1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-655-3p | MIMAT0003331 | 0.011 | -0.29 | 78 |
ACC | hsa-miR-655-3p | MIMAT0003331 | 0.011 | -0.29 | 78 |
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TissGeneMut for POU4F1 |
TissGeneSNV for POU4F1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E366K | UCEC | 1 |
p.L282P | UCEC | 1 |
p.A375T | LIHC | 1 |
p.W402G | HNSC | 1 |
p.R279H | STAD | 1 |
p.E342X | STAD | 1 |
p.E348Q | OV | 1 |
p.E371K | LIHC | 1 |
p.E269Q | BLCA | 1 |
p.L293P | BLCA | 1 |
p.A387T | UCEC | 1 |
p.H74Q | SKCM | 1 |
p.M4K | LUAD | 1 |
p.S369C | SKCM | 1 |
p.K297R | LIHC | 1 |
p.C404F | KIRP | 1 |
p.D264Y | LUAD | 1 |
p.A387V | STAD | 1 |
p.M344I | OV | 1 |
p.P9H | STAD | 1 |
p.S29F | LUAD | 1 |
p.T95M | UCEC | 1 |
p.E342* | STAD | 1 |
p.E112K | UCEC | 1 |
p.N86D | LUSC | 1 |
p.A324S | LUAD | 1 |
p.E371K | UCEC | 1 |
p.E313K | BLCA | 1 |
p.E366D | UCEC | 1 |
p.E366D | BLCA | 1 |
p.E334Q | CESC | 1 |
p.T263M | HNSC | 1 |
p.K396N | COAD | 1 |
p.S303L | BLCA | 1 |
p.A372S | UCEC | 1 |
p.P75L | SKCM | 1 |
p.E383D | LUSC | 1 |
p.R412Q | COAD | 1 |
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TissGeneCNV for POU4F1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for POU4F1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for POU4F1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for POU4F1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for POU4F1 |
TissGeneDrug for POU4F1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for POU4F1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0302592 | Cervix carcinoma | 6 | BeFree |
umls:C0007847 | Malignant tumor of cervix | 5 | BeFree |
umls:C0027819 | Neuroblastoma | 4 | BeFree |
umls:C0030354 | Papilloma | 4 | BeFree,LHGDN |
umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree,CTD_human |
umls:C0262407 | cervical abnormality | 3 | BeFree |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0700095 | Central neuroblastoma | 3 | BeFree |
umls:C0023798 | Lipoma | 2 | BeFree |
umls:C0206708 | Cervical Intraepithelial Neoplasia | 2 | BeFree,CTD_human |
umls:C0007867 | Cervix Diseases | 1 | BeFree |
umls:C0007873 | Uterine Cervical Neoplasm | 1 | CTD_human |
umls:C0008626 | Congenital chromosomal disease | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0031511 | Pheochromocytoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0035412 | Rhabdomyosarcoma | 1 | BeFree |
umls:C0085648 | Synovial Cyst | 1 | BeFree |
umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C1258666 | Myxoid cyst | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1306214 | ACTH-Secreting Pituitary Adenoma | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |